Understanding the benefit of metformin use in cancer treatment

Gene signature of metformin actions on primary breast cancer within a window of opportunity randomized clinical trial.

(2017) S. M. Hadad et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

(2011) Irina N. Alimova et al.   CELL CYCLE

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

(2011) Bolin Liu et al.   CELL CYCLE

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

(2010) Pamela J. Goodwin et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis

(2010) R. M. Memmott et al.   Cancer Prevention Research

Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial

(2010) K. Hosono et al.   Cancer Prevention Research

Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

(2010) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond

(2010) Lev M Berstein   Future Oncology

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

(2010) Kunihiro Hosono et al.   MOLECULAR CARCINOGENESIS

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

(2010) C Algire et al.   ONCOGENE

Obesity and Cancer Risk: Recent Review and Evidence

(2010) Karen Basen-Engquist et al.   Current Oncology Reports

Status of PI3K inhibition and biomarker development in cancer therapeutics

(2009) B. Markman et al.   ANNALS OF ONCOLOGY

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Sulphonylureas and cancer: a case–control study

(2008) Matteo Monami et al.   ACTA DIABETOLOGICA

Metformin suppresses intestinal polyp growth in ApcMin/+ mice

(2008) Ayako Tomimoto et al.   CANCER SCIENCE

Insulin-Lowering Effects of Metformin in Women with Early Breast Cancer

(2008) Pamela J. Goodwin et al.   Clinical Breast Cancer

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

(2008) C. Algire et al.   ENDOCRINE-RELATED CANCER

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

(2008) Walter H. Gotlieb et al.   GYNECOLOGIC ONCOLOGY

IGF and Insulin Receptor Signaling in Breast Cancer

(2008) Antonino Belfiore et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

The role of insulin receptors and IGF-I receptors in cancer and other diseases

(2008) Francesco Frasca et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY