Mitochondria as a therapeutic target for common pathologies

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Calcium and regulation of the mitochondrial permeability transition

(2018) Valentina Giorgio et al.   CELL CALCIUM

Bcl-2 on the brink of breakthroughs in cancer treatment

(2018) John C Reed   CELL DEATH AND DIFFERENTIATION

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

Mitochondrial protein S- nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle

(2018) Rebecca J. Wilson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Quantitative in vivo mapping of myocardial mitochondrial membrane potential

(2018) Nathaniel M. Alpert et al.   PLoS One

Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C

(2018) Björn Ingelsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size

(2018) Laura Valls-Lacalle et al.   Scientific Reports

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

(2018) Matthias Kohlhauer et al.   Journal of the American Heart Association

Inhibition of mitochondrial fragmentation protects against Alzheimer’s disease in rodent model

(2017) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

Clinical benefit of drugs targeting mitochondrial function as an adjunct to reperfusion in ST-segment elevation myocardial infarction: A meta-analysis of randomized clinical trials

(2017) Gianluca Campo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

(2017) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial dysfunction underlying outer retinal diseases

(2017) Evy Lefevere et al.   MITOCHONDRION

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

(2017) Daniel J. Tyrrell et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

(2017) David Sebastián et al.   TRENDS IN MOLECULAR MEDICINE

Is the Mitochondrion a Good Malaria Drug Target?

(2017) Christopher D. Goodman et al.   TRENDS IN PARASITOLOGY

Using chemical biology to assess and modulate mitochondria: progress and challenges

(2017) Angela Logan et al.   Interface Focus

Non-enzymatic N -acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S -acetylated Thiol Intermediate Sensitive to Glyoxalase II

(2017) Andrew M. James et al.   Cell Reports

In Vivo Assessment of Mitochondrial Dysfunction in Clinical Populations Using Near-Infrared Spectroscopy

(2017) T. Bradley Willingham et al.   Frontiers in Physiology

Mitochondrial Control and Guidance of Cellular Activities of T Cells

(2017) Tung Chao et al.   Frontiers in Immunology

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease

(2017) Simone Bido et al.   Scientific Reports

Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria

(2016) Sae Rin Jean et al.   ACCOUNTS OF CHEMICAL RESEARCH

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice

(2016) T. Rubić-Schneider et al.   ALLERGY

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

(2016) Derek J. Hausenloy et al.   BASIC RESEARCH IN CARDIOLOGY

A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death

(2016) Hwajin Kim et al.   BMC NEUROSCIENCE

Emerging therapies for mitochondrial disorders

(2016) Helen Nightingale et al.   BRAIN

Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases

(2016) Li Yue et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure

(2016) Annalinda Pisano et al.   CARDIOVASCULAR PATHOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Calcium and reactive oxygen species in regulation of the mitochondrial permeability transition and of programmed cell death in yeast

(2016) Michela Carraro et al.   CELL CALCIUM

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

(2016) Angela Logan et al.   Cell Metabolism

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Moving Forwards by Blocking Back-Flow

(2016) Victoria R. Pell et al.   CIRCULATION RESEARCH

Contribution of mitochondrial oxidative stress to hypertension

(2016) Sergey I. Dikalov et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

(2016) Rui Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contribution of Alcoholic and Nonalcoholic Fatty Liver Disease to the Burden of Liver-Related Morbidity and Mortality

(2016) Zobair Younossi et al.   GASTROENTEROLOGY

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclosporine A in Reperfused Myocardial Infarction

(2016) Filippo Ottani et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

(2016) Louise A. Hyslop et al.   NATURE

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

The trypanosome alternative oxidase: a potential drug target?

(2016) STEFANIE K. MENZIES et al.   PARASITOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

NAMPT-Mediated NAD + Biosynthesis Is Essential for Vision In Mice

(2016) Jonathan B. Lin et al.   Cell Reports

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

(2016) Euy‐Myoung Jeong et al.   Journal of the American Heart Association

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health

(2016) Daniel J. Tyrrell et al.   Redox Biology

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis

(2016) Mona Sadeghian et al.   Scientific Reports

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

(2015) Aaron N Long et al.   BMC Neurology

Mitochondrial apoptosis: killing cancer using the enemy within

(2015) J Lopez et al.   BRITISH JOURNAL OF CANCER

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition

(2015) Laura Valls-Lacalle et al.   CARDIOVASCULAR RESEARCH

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

(2015) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

(2015) C. Michael Gibson et al.   EUROPEAN HEART JOURNAL

Mitochondria and the hallmarks of cancer

(2015) Evangelos Giampazolias et al.   FEBS Journal

Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat

(2015) Ellen L. Robb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

(2015) Anna J. Dare et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration

(2015) M. R. Terluk et al.   JOURNAL OF NEUROSCIENCE

Metabolic rescue in pluripotent cells from patients with mtDNA disease

(2015) Hong Ma et al.   NATURE

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo

(2015) Markus Nussbaumer et al.   NEUROPSYCHOPHARMACOLOGY

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses

(2015) Qianni Hu et al.   PLoS One

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress

(2015) Martin Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

(2015) Julie Thompson Legault et al.   Cell Reports

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Mitochondrial Proteostasis in the Control of Aging and Longevity

(2014) Martin Borch Jensen et al.   Cell Metabolism

Impaired In Vivo Mitochondrial Krebs Cycle Activity After Myocardial Infarction Assessed Using Hyperpolarized Magnetic Resonance Spectroscopy

(2014) Michael S. Dodd et al.   Circulation-Cardiovascular Imaging

The Bioenergetic Health Index: a new concept in mitochondrial translational research

(2014) Balu K. Chacko et al.   CLINICAL SCIENCE

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results

(2014) D. Atar et al.   EUROPEAN HEART JOURNAL

Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

(2014) Ernesto Miquel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Mitochondria in Nonalcoholic Fatty Liver Disease

(2014) Fatiha Nassir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Mitochondrial dysfunction and oxidative stress in CHF

(2014) Darlington O. Okonko et al.   Nature Reviews Cardiology

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Promise and Perils of Antioxidants for Cancer Patients

(2014) Navdeep S. Chandel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel inhibitors of the Plasmodium falciparum electron transport chain

(2014) P. A. STOCKS et al.   PARASITOLOGY

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

(2014) C R R Rocha et al.   Cell Death & Disease

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

G-Protein–Coupled Receptor 91 and Succinate Are Key Contributors in Neonatal Postcerebral Hypoxia-Ischemia Recovery

(2013) David Hamel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease

(2013) Sergey Zharikov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Using exomarkers to assess mitochondrial reactive species in vivo

(2013) Angela Logan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

(2013) Sheree D. Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial dysfunction and complications associated with diabetes

(2013) Rachel Blake et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

(2013) Amarjargal Dashdorj et al.   BMC Medicine

Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models

(2013) J C Komen et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes

(2013) Pamela Boon Li Pun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension

(2013) Alfonso Eirin et al.   JOURNAL OF HYPERTENSION

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function

(2013) Jennifer McLachlan et al.   JOURNAL OF HYPERTENSION

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes

(2013) Soo Jin Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

(2013) Marija Dulovic et al.   NEUROBIOLOGY OF DISEASE

New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation

(2013) Martin Pelletier et al.   SEMINARS IN IMMUNOLOGY

Recommendations on Angiographic Revascularization Grading Standards for Acute Ischemic Stroke

(2013) Osama O. Zaidat et al.   STROKE

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

New advances in beta-blocker therapy in heart failure

(2013) Vincenzo Barrese et al.   Frontiers in Physiology

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

(2012) Riccardo Calvani et al.   BIOLOGICAL CHEMISTRY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Mitochondrial dysfunction in heart failure

(2012) Mariana G. Rosca et al.   HEART FAILURE REVIEWS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria in cardiac hypertrophy and heart failure

(2012) Mariana G. Rosca et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondria as a Therapeutic Target in Heart Failure

(2012) Marina Bayeva et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

(2012) Rajnish K. Chaturvedi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The mitochondrial transporter family SLC25: Identification, properties and physiopathology

(2012) Ferdinando Palmieri   MOLECULAR ASPECTS OF MEDICINE

Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation

(2012) Thomas H. Sanderson et al.   MOLECULAR NEUROBIOLOGY

Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies

(2012) Erwan Bezard et al.   MOVEMENT DISORDERS

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

(2012) Helena M Cochemé et al.   Nature Protocols

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

Mitochondrial oxidative stress and the metabolic syndrome

(2012) Andrew M. James et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

(2012) Ana Carolina Ariza et al.   Frontiers in Endocrinology

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

(2011) Andrea Rasola et al.   CELL CALCIUM

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

(2011) Carlo Viscomi et al.   Cell Metabolism

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice

(2011) John R. Mercer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice

(2011) Shuichi Yatsuga et al.   HUMAN MOLECULAR GENETICS

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

(2011) Susan Chalmers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Mitochondria and Trypanosomatids: Targets and Drugs

(2011) Lianet Monzote Fidalgo et al.   PHARMACEUTICAL RESEARCH

Recombinant Tissue-Type Plasminogen Activator Use for Ischemic Stroke in the United States

(2011) Opeolu Adeoye et al.   STROKE

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Identification of S-nitrosated mitochondrial proteins byS-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

(2010) Edward T. Chouchani et al.   BIOCHEMICAL JOURNAL

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cyclosporine A at Reperfusion Reduces Infarct Size in Pigs

(2010) Andreas Skyschally et al.   CARDIOVASCULAR DRUGS AND THERAPY

Mitochondria in heart failure

(2010) M. G. Rosca et al.   CARDIOVASCULAR RESEARCH

PGC-1 Coactivators in Cardiac Development and Disease

(2010) Glenn C. Rowe et al.   CIRCULATION RESEARCH

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Mitochondrial myopathies: developments in treatment

(2010) Adam Hassani et al.   CURRENT OPINION IN NEUROLOGY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry

(2010) Fionnuala Morrish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation

(2010) Jens Lutz et al.   Journal of Inflammation-London

TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition

(2010) S. Schaller et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Evolution and Functions in Malaria Parasites

(2009) Akhil B. Vaidya et al.   Annual Review of Microbiology

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ABC proteins in health and disease

(2009) Ariane Zutz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria in Huntington's disease

(2009) Maria Damiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria: A therapeutic target in neurodegeneration

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

Phototransduction Motifs and Variations

(2009) King-Wai Yau et al.   CELL

Expression of the Ciona intestinalis Alternative Oxidase (AOX) in Drosophila Complements Defects in Mitochondrial Oxidative Phosphorylation

(2009) Daniel J.M. Fernandez-Ayala et al.   Cell Metabolism

Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Why Do We Still Not Have Cardioprotective Drugs?

(2009) James M. Downey et al.   CIRCULATION JOURNAL

A modern approach to the treatment of mitochondrial disease

(2009) Sumit Parikh et al.   Current Treatment Options in Neurology

Impaired PGC-1α function in muscle in Huntington's disease

(2009) Rajnish K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness

(2009) G. S. Supinski et al.   JOURNAL OF APPLIED PHYSIOLOGY

Domestication of the cardiac mitochondrion for energy conversion

(2009) Robert S. Balaban   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of Bariatric Surgery on the Metabolic Syndrome: A Population-Based, Long-term Controlled Study

(2009) John A. Batsis et al.   MAYO CLINIC PROCEEDINGS

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism

(2009) F. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

(2009) T. A. Prime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

(2009) F. F. Severin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitochondria-Penetrating Peptides

(2008) Kristin L. Horton et al.   CHEMISTRY & BIOLOGY

ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light

(2008) Haruhisa Okawa et al.   CURRENT BIOLOGY

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Computer-assisted live cell analysis of mitochondrial membrane potential, morphology and calcium handling

(2008) Werner J.H. Koopman et al.   METHODS

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell-penetrating peptides as delivery vehicles for biology and medicine

(2008) Kelly M. Stewart et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ischemia/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention

(2008) M. Kosieradzki et al.   TRANSPLANTATION PROCEEDINGS