Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

(2018) Isabelle Arnoux et al.   eLife

Metformin – a Future Therapy for Neurodegenerative Diseases

(2017) Magdalena Markowicz-Piasecka et al.   PHARMACEUTICAL RESEARCH

Metformin intake associates with better cognitive function in patients with Huntington's disease

(2017) David Hervás et al.   PLoS One

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

(2016) Anne H.P. Jansen et al.   GLIA

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

(2016) Amber L. Southwell et al.   HUMAN MOLECULAR GENETICS

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease

(2016) Qi Peng et al.   PLoS One

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

(2015) Rafael P. Vázquez-Manrique et al.   HUMAN MOLECULAR GENETICS

Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease

(2015) Qian Ma et al.   NEUROBIOLOGY OF DISEASE

The choreography of neuroinflammation in Huntington's disease

(2015) Andrea Crotti et al.   TRENDS IN IMMUNOLOGY

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

(2015) Nikisha Carty et al.   PLoS One

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

(2014) D. Grahame Hardie et al.   PHYSIOLOGY

Ubiquitin–proteasome system involvement in Huntington’s disease

(2014) Zaira Ortega et al.   Frontiers in Molecular Neuroscience

Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease

(2013) Carmela Giampà et al.   PLoS One

Principles for Valid Histopathologic Scoring in Research

(2013) K. N. Gibson-Corley et al.   VETERINARY PATHOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

(2012) Taneli Heikkinen et al.   PLoS One

Huntington's disease: From molecular basis to therapeutic advances

(2010) Sylvia Krobitsch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

Improved gene targeting in C. elegans using counter-selection and Flp-mediated marker excision

(2009) Rafael P. Vázquez-Manrique et al.   GENOMICS

Tests to assess motor phenotype in mice: a user's guide

(2009) Simon P. Brooks et al.   NATURE REVIEWS NEUROSCIENCE

Inositol 1,4,5-Trisphosphate Signalling Regulates the Avoidance Response to Nose Touch in Caenorhabditis elegans

(2009) Denise S. Walker et al.   PLoS Genetics

Single-copy insertion of transgenes in Caenorhabditis elegans

(2008) Christian Frøkjær-Jensen et al.   NATURE GENETICS