The role of lipid droplets in metabolic disease in rodents and humans

Expression of Perilipin and Adipophilin in Nonalcoholic Fatty Liver Disease; Relevance to Oxidative Injury and Hepatocyte Ballooning

(2011) Hideki Fujii et al.   Journal of Atherosclerosis and Thrombosis

Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy

(2011) Sheetal Gandotra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK

(2010) Mandeep P. Gaidhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

β3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK

(2010) Emilio P. Mottillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure

(2010) Enhui Wei et al.   Cell Metabolism

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

(2010) Xingyuan Yang et al.   Cell Metabolism

The role and importance of brown adipose tissue in energy homeostasis

(2010) Aaron M Cypess et al.   CURRENT OPINION IN PEDIATRICS

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

(2010) Pontus Boström et al.   DIABETES

Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population

(2010) Ling Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes

(2010) Srijana Ranjit et al.   JOURNAL OF LIPID RESEARCH

Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice

(2010) Benny Hung-Junn Chang et al.   JOURNAL OF LIPID RESEARCH

Association of Lifestyle Factors, Polymorphisms in Adiponectin, Perilipin and Hormone Sensitive Lipase, and Clinical Markers in Japanese Males

(2010) Yasuko SONE et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype

(2010) Takashi Sawada et al.   PLoS One

Disruption of theArabidopsisCGI-58 homologue produces Chanarin–Dorfman-like lipid droplet accumulation in plants

(2010) Christopher N. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

(2010) Achim Lass et al.   PROGRESS IN LIPID RESEARCH

Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA

(2009) Kun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B

(2009) Jing Ye et al.   Cell Metabolism

Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1

(2009) L. Liu et al.   DIABETES

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome

(2009) Toshihide Kawai et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation inCIDEC

(2009) Oscar Rubio-Cabezas et al.   EMBO Molecular Medicine

Diet-induced hepatocellular carcinoma in genetically predisposed mice

(2009) A. E. Hill-Baskin et al.   HUMAN MOLECULAR GENETICS

Endurance exercise training effects on body fatness, V̇o2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians

(2009) Nathan T. Jenkins et al.   JOURNAL OF APPLIED PHYSIOLOGY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

(2009) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets at a glance

(2009) Y. Guo et al.   JOURNAL OF CELL SCIENCE

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus

(2009) Ronnie Minnaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dynamic and differential regulation of proteins that coat lipid droplets infatty liver dystrophicmice

(2009) Angela M. Hall et al.   JOURNAL OF LIPID RESEARCH

Perilipin overexpression in mice protects against diet-induced obesity

(2009) Hideaki Miyoshi et al.   JOURNAL OF LIPID RESEARCH

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity

(2009) Jessica M. Sapiro et al.   JOURNAL OF LIPID RESEARCH

Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance

(2009) Stijn Soenen et al.   PHYSIOLOGY & BEHAVIOR

Assessment of fat-specific protein 27 in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell death

(2008) Ji Young Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition of ADRP prevents diet-induced insulin resistance

(2008) Gladys M. Varela et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes

(2008) Cédric M. Blouin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chanarin–Dorfman syndrome: Deficiency in CGI-58, a lipid droplet-bound coactivator of lipase

(2008) Tomohiro Yamaguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells

(2008) M. T. Accioly et al.   CANCER RESEARCH

Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27

(2008) Kimihiko Matsusue et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis

(2008) Antoni Paul et al.   CIRCULATION RESEARCH

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

(2008) M. Bell et al.   DIABETES

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

(2008) Jingzong Qi et al.   EMBO JOURNAL

Differential pattern of lipid droplet-associated proteins andde novoperilipin expression in hepatocyte steatogenesis

(2008) Beate Katharina Straub et al.   HEPATOLOGY

The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

(2008) Scot J. Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fat-specific Protein 27 Regulates Storage of Triacylglycerol

(2008) Pernille Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte

(2008) Marie-Soleil Gauthier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Gregarious Lipid Droplet

(2008) Joel M. Goodman   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes

(2008) Hideaki Miyoshi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of Perilipin (PLIN) Gene Variation on Metabolic Syndrome Risk and Weight Loss in Obese Children and Adolescents

(2008) Sophie Deram et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of a Homozygous Nonsense Caveolin-1 Mutation with Berardinelli-Seip Congenital Lipodystrophy

(2008) C. A. Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Lack of the C-Terminal Domain of Adipose Triglyceride Lipase Causes Neutral Lipid Storage Disease through Impaired Interactions with Lipid Droplets

(2008) Kunihisa Kobayashi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cell death–inducing DNA fragmentation factor α–like effector A (CIDEA) gene V115F (G→T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men

(2008) Ling Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Common Variations in Perilipin Gene, Central Obesity, and Risk of Type 2 Diabetes in US Women

(2008) Lu Qi et al.   Obesity

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

(2008) Shen Yon Toh et al.   PLoS One

Cidea is associated with lipid droplets and insulin sensitivity in humans

(2008) V. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COPI Complex Is a Regulator of Lipid Homeostasis

(2008) Mathias Beller et al.   PLOS BIOLOGY