Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non‐alcoholic fatty liver disease

Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease

(2020) Stefano Romeo et al.   Cell Metabolism

Association of HSD17B13 rs72613567:TA with non‐alcoholic fatty liver disease in Hispanics/Latinos

(2020) Eric Kallwitz et al.   LIVER INTERNATIONAL

A HSD 17B13 variant protects from hepatocellular carcinoma development in alcoholic liver disease

(2019) Jie Yang et al.   HEPATOLOGY

PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

(2019) Yang Wang et al.   HEPATOLOGY

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

(2019) Daniel Lindén et al.   Molecular Metabolism

High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase‐Lowering effect of a HSD 17B13 Variant

(2019) Helene Gellert‐Kristensen et al.   HEPATOLOGY

Towards Precision Medicine in Nonalcoholic Fatty Liver Disease with PNPLA3 as a Therapeutic Target

(2019) Massimo Colombo et al.   GASTROENTEROLOGY

17-beta-hydroxysteroid dehydrogenase 13 inhibits the progression and recurrence of hepatocellular carcinoma

(2018) Jun Chen et al.   Hepatobiliary & Pancreatic Diseases International

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011–2015 update

(2018) Ryosuke Tateishi et al.   JOURNAL OF GASTROENTEROLOGY

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression

(2016) Yuya Seko et al.   HEPATOLOGY RESEARCH

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2015) Sumio Watanabe et al.   JOURNAL OF GASTROENTEROLOGY

The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis

(2014) Amit G Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

(2012) Takahisa Kawaguchi et al.   PLoS One

Large-Scale Long-Term Follow-Up Study of Japanese Patients With Non-Alcoholic Fatty Liver Disease for the Onset of Hepatocellular Carcinoma

(2011) Yusuke Kawamura et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Clinicopathological features of non-alcoholic fatty liver disease

(2011) Kazushi Sugimoto et al.   HEPATOLOGY RESEARCH

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors

(2009) Anna Kotronen et al.   GASTROENTEROLOGY

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

17β-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein

(2008) Yuka Horiguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS