Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting

(2020) Enxiang Zhang et al.   JOURNAL OF LIPID RESEARCH

A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study

(2020) Claire S. Faulkner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD

(2020) Shuoyi Ma et al.   LIVER INTERNATIONAL

Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non‐alcoholic fatty liver disease

(2020) Yuya Seko et al.   LIVER INTERNATIONAL

Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?

(2020) Dominika Maciejewska et al.   MOLECULES

Structure and mechanism of human diacylglycerol O-acyltransferase 1

(2020) Lie Wang et al.   NATURE

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

(2020) Kay H. M. Roumans et al.   Nature Communications

Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice

(2020) Pan Yang et al.   Scientific Reports

Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy

(2020) Liyang Wang et al.   Cell and Bioscience

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

(2020) Matteo Tardelli   WORLD JOURNAL OF GASTROENTEROLOGY

Lipophagy Impairment Is Associated With Disease Progression in NAFLD

(2020) Simone Carotti et al.   Frontiers in Physiology

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

(2019) Stacey N. Keenan et al.   DIABETES

A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver

(2019) Christina Preuss et al.   Cells

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

(2019) Kamil Sołtysik et al.   Nature Communications

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

(2019) Manuele Piccolis et al.   MOLECULAR CELL

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet

(2019) Amar B. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic stellate cell activation: A source for bioactive lipids

(2019) Igor O. Shmarakov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme DGAT 2 Reduces Steatosis without Increasing Inflammation or Fibrosis

(2019) Nina L. Gluchowski et al.   HEPATOLOGY

The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux

(2019) Xiaoting Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

(2019) Matteo Tardelli et al.   JOURNAL OF LIPID RESEARCH

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

(2019) Daniel Lindén et al.   Molecular Metabolism

The biogenesis of lipid droplets: Lipids take center stage

(2019) Mingming Gao et al.   PROGRESS IN LIPID RESEARCH

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Hepatocyte Elovl6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice

(2019) Takashi Matsuzaka et al.   HEPATOLOGY

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

(2019) Micah B. Schott et al.   JOURNAL OF CELL BIOLOGY

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease

(2019) Meng Jiang et al.   Frontiers in Endocrinology

A twist of FATe: Lipid droplets and inflammatory lipid mediators

(2019) Eva Jarc et al.   BIOCHIMIE

Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

(2019) Ji-Yeon Shin et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis

(2019) Neeta B. Amin et al.   Science Translational Medicine

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

(2019) Robert N Helsley et al.   eLife

Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells

(2019) Tan et al.   Cells

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

(2019) Charles P. Najt et al.   MOLECULAR CELL

Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly

(2018) Ariel D. Quiroga et al.   BIOCHEMICAL PHARMACOLOGY

Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis

(2018) Jihong Lian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

(2018) Montserrat A. de la Rosa Rodriguez et al.   BMC GENOMICS

The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets

(2018) Anete Romanauska et al.   CELL

DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates

(2018) David G. McLaren et al.   Cell Metabolism

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway

(2018) Xinhong Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

(2018) Matthew A. Mitsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase

(2018) Krishna M. Padmanabha Das et al.   JOURNAL OF LIPID RESEARCH

Fasting and refeeding induces changes in the mouse hepatic lipid droplet proteome

(2018) David A. Kramer et al.   Journal of Proteomics

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid Droplets as Immune Modulators in Myeloid Cells

(2018) Martijn H. den Brok et al.   TRENDS IN IMMUNOLOGY

Role of DGAT enzymes in triacylglycerol metabolism

(2018) Bhumika Bhatt-Wessel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes

(2018) Florentina Negoita et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging mass spectrometry reveals molecular differences in micro and macro steatosis

(2018) Hussam Alamri et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Omega-3 fatty acids and nonalcoholic fatty liver disease in adults and children

(2018) Melinda H. Spooner et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis

(2018) Natalie Krahmer et al.   DEVELOPMENTAL CELL

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

(2018) Brian N. Finck   DIABETES

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

(2018) Aida Habib et al.   GUT

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

Raman spectroscopy-based insight into lipid droplets presence and contents in liver sinusoidal endothelial cells and hepatocytes

(2018) Ewelina Szafraniec et al.   Journal of Biophotonics

Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease

(2018) Carlos J. Pirola et al.   JOURNAL OF LIPID RESEARCH

Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity

(2018) Lu-Min Shih et al.   MOLECULES

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Decreasing Phosphatidylcholine on the Surface of the Lipid Droplet Correlates with Altered Protein Binding and Steatosis

(2018) Laura Listenberger et al.   Cells

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

(2017) Cristina Alonso et al.   GASTROENTEROLOGY

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease

(2017) Fernando Bril et al.   HEPATOLOGY

Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK

(2017) Qi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

(2017) Elisa Álvarez Hernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

(2017) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Differential proteomics profiling identifies LDPs and biological functions in high-fat diet-induced fatty livers

(2017) Mingwei Liu et al.   JOURNAL OF LIPID RESEARCH

TM6SF2 rs58542926 variant affects postprandial lipoprotein metabolism and glucose homeostasis in NAFLD

(2017) Giovanni Musso et al.   JOURNAL OF LIPID RESEARCH

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

(2017) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes

(2017) Aki Juhani Käräjämäki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease

(2017) Seungwoo Lee et al.   Oncotarget

ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism

(2017) Aishwarya Sathyanarayan et al.   Cell Reports

Reduced expression of adipose triglyceride lipase decreases arachidonic acid release and prostacyclin secretion in human aortic endothelial cells

(2017) Monika Riederer et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets

(2017) Pengfei Zheng et al.   Scientific Reports

Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis

(2016) Charles P. Najt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites

(2016) You Zhou et al.   Clinical Gastroenterology and Hepatology

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Circadian Clock Control of Liver Metabolic Functions

(2016) Hans Reinke et al.   GASTROENTEROLOGY

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

(2016) Wenyi Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

(2016) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

Sirtuins and nonalcoholic fatty liver disease

(2016) Fatiha Nassir et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

(2016) Violeta I. Gallardo-Montejano et al.   Nature Communications

Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma

(2016) Junyong Zhang et al.   Scientific Reports

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation

(2016) Caleb C. Lord et al.   Cell Reports

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins

(2016) Wenwei Zhang et al.   Cell Reports

Liver-specific G0 /G1 switch gene 2 (G0s2) expression promotes hepatic insulin resistance by exacerbating hepatic steatosis in male Wistar rats

(2016) Yoshiyuki Sugaya et al.   Journal of Diabetes

Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance

(2016) Xiulan Chen et al.   Scientific Reports

Ces3/TGH Deficiency Attenuates Steatohepatitis

(2016) Jihong Lian et al.   Scientific Reports

Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes

(2015) C. Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

(2015) Wudelehu Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans

(2015) Manoj Amrutkar et al.   DIABETOLOGIA

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

(2015) Manoj Amrutkar et al.   FASEB JOURNAL

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis

(2015) Cédric Langhi et al.   HEPATOLOGY

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Saturated phosphatidic acids mediate saturated fatty acid–induced vascular calcification and lipotoxicity

(2015) Masashi Masuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

(2015) You Zhou et al.   JOURNAL OF HEPATOLOGY

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis

(2015) S. Schlager et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosis

(2015) Salmaan Ahmed Khan et al.   JOURNAL OF LIPID RESEARCH

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

(2015) D. Lee Gorden et al.   JOURNAL OF LIPID RESEARCH

Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome

(2015) Maddalena Parafati et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

New Evidence for the Role of Ceramide in the Development of Hepatic Insulin Resistance

(2015) Karolina Konstantynowicz-Nowicka et al.   PLoS One

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

Proteomic analysis of murine testes lipid droplets

(2015) Weiyi Wang et al.   Scientific Reports

Structural and Functional Assessment of Perilipin 2 Lipid Binding Domain(s)

(2014) Charles P. Najt et al.   BIOCHEMISTRY

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

(2014) Yaarit Adamovich et al.   Cell Metabolism

Lipid droplet biogenesis

(2014) Florian Wilfling et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations

(2014) Dariush Mohammadyani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathological Features of Fatty Liver Disease

(2014) Matthew M. Yeh et al.   GASTROENTEROLOGY

Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

(2014) Eriks Smagris et al.   HEPATOLOGY

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Fat-specific Protein 27 (FSP27) Interacts with Adipose Triglyceride Lipase (ATGL) to Regulate Lipolysis and Insulin Sensitivity in Human Adipocytes

(2014) Tan Hooi Min Grahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells

(2014) Andrea Dichlberger et al.   JOURNAL OF LIPID RESEARCH

Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

(2014) Kuok Teong Ong et al.   JOURNAL OF LIPID RESEARCH

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

(2014) Rotonya M. Carr et al.   PLoS One

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

(2014) W. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

(2014) Yang-Lin Liu et al.   Nature Communications

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an α-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humans

(2013) Joëlle Magné et al.   FASEB JOURNAL

Monoacylglycerol Lipase Controls Endocannabinoid and Eicosanoid Signaling and Hepatic Injury in Mice

(2013) Zongxian Cao et al.   GASTROENTEROLOGY

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

Perilipin discerns chronic from acute hepatocellular steatosis

(2013) Lena Maria Pawella et al.   JOURNAL OF HEPATOLOGY

Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice

(2013) Feng Guo et al.   JOURNAL OF LIPID RESEARCH

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

(2013) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease

(2013) April D. Lake et al.   TOXICOLOGICAL SCIENCES

Nuclear lipid droplets: A novel nuclear domain

(2012) J.P. Layerenza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides andde novosynthesized fatty acids in HepG2 cells

(2012) Haja R. Wurie et al.   FEBS Journal

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

(2012) Jihong Lian et al.   HEPATOLOGY

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases

(2012) Thomas O. Eichmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

(2012) Anne Leroux et al.   JOURNAL OF HEPATOLOGY

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

(2012) Jenson Qi et al.   JOURNAL OF LIPID RESEARCH

LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice

(2012) Hyeon-Cheol Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Increased risk of cardiovascular disease and chronic kidney disease in NAFLD

(2012) Enzo Bonora et al.   Nature Reviews Gastroenterology & Hepatology

Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression

(2012) Yumi Imai et al.   PHYSIOLOGICAL GENOMICS

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling

(2011) Rosalind A. Coleman et al.   CHEMICAL REVIEWS

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis

(2011) Jiang Wei Wu et al.   HEPATOLOGY

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Lipid body formation during maturation of human mast cells

(2011) Andrea Dichlberger et al.   JOURNAL OF LIPID RESEARCH

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption

(2010) Jaimie N Davis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

(2010) S. M. Turpin et al.   DIABETOLOGIA

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication

(2010) David R. Blais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways

(2010) So Young Bu et al.   JOURNAL OF LIPID RESEARCH

Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis

(2010) Beate K Straub et al.   MODERN PATHOLOGY

Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression

(2010) Huajin Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

(2010) Maryam Rakhshandehroo et al.   PPAR Research

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids

(2009) Claudio J. Villanueva et al.   HEPATOLOGY

Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition

(2009) Lei O. Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity

(2009) Jessica M. Sapiro et al.   JOURNAL OF LIPID RESEARCH

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver

(2008) Nila Rafiq et al.   Clinical Gastroenterology and Hepatology

Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

(2008) Anna Kotronen et al.   GASTROENTEROLOGY

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice

(2008) Montserrat Pinent et al.   GENOMICS

Differential pattern of lipid droplet-associated proteins andde novoperilipin expression in hepatocyte steatogenesis

(2008) Beate Katharina Straub et al.   HEPATOLOGY

AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase

(2008) Yan Qun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY

Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis

(2008) Motohiro Sekiya et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY