Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy

(2019) Boris Fichtman et al.   Nature Communications

An integrative systems genetic analysis of mammalian lipid metabolism

(2019) Benjamin L. Parker et al.   NATURE

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease

(2018) Graham F. Brady et al.   HEPATOLOGY

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects

(2018) Eeva Sliz et al.   HUMAN MOLECULAR GENETICS

Lipid transfer proteins in the assembly of apoB-containing lipoproteins

(2018) Alaa Sirwi et al.   JOURNAL OF LIPID RESEARCH

The Association Between Nonalcoholic Fatty Liver Disease and Metabolic Abnormalities in The United States Population

(2017) Raxitkumar Jinjuvadia et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Torsins Are Essential Regulators of Cellular Lipid Metabolism

(2016) Micheline Grillet et al.   DEVELOPMENTAL CELL

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

PML isoform II plays a critical role in nuclear lipid droplet formation

(2016) Yuki Ohsaki et al.   JOURNAL OF CELL BIOLOGY

Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis

(2016) Donna M. Conlon et al.   JOURNAL OF CLINICAL INVESTIGATION

TOR1AIP1 as a cause of cardiac failure and recessive limb-girdle muscular dystrophy

(2016) Roula Ghaoui et al.   NEUROMUSCULAR DISORDERS

Metabolic syndrome update

(2016) Scott M. Grundy   TRENDS IN CARDIOVASCULAR MEDICINE

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

(2016) Pei-Ling Tsai et al.   eLife

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

(2015) Sanjaya Satapathy et al.   SEMINARS IN LIVER DISEASE

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

(2015) Paola Dongiovanni et al.   Biomed Research International

TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

(2014) Chun-Chi Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia

(2014) Mathilde Di Filippo et al.   JOURNAL OF HEPATOLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Mutation in TOR1AIP1 encoding LAP1B in a form of muscular dystrophy: A novel gene related to nuclear envelopathies

(2014) Gulsum Kayman-Kurekci et al.   NEUROMUSCULAR DISORDERS

Lamina-Associated Polypeptide-1 Interacts with the Muscular Dystrophy Protein Emerin and Is Essential for Skeletal Muscle Maintenance

(2013) Ji-Yeon Shin et al.   DEVELOPMENTAL CELL

Regulation of Torsin ATPases by LAP1 and LULL1

(2013) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

(2013) J. L. Cantley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein B Secretory Regulation by Degradation

(2012) Sven-Olof Olofsson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α

(2012) Chris N. Goulbourne et al.   JOURNAL OF CELL SCIENCE

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

(2012) Richard G. Lee et al.   JOURNAL OF LIPID RESEARCH

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

(2012) Wilhelm Palm et al.   PLoS Genetics

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

(2010) C. E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Envelope as a Signaling Node in Development and Disease

(2009) William T. Dauer et al.   DEVELOPMENTAL CELL

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism

(2008) Henry N. Ginsberg et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS