Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

(2019) Yang Wang et al.   HEPATOLOGY

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes

(2018) Connie N. Hess et al.   Annual Review of Medicine

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

(2018) Matthew A. Mitsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators

(2017) Anthony D. Gromovsky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis

(2016) Daniel Ferguson et al.   JOURNAL OF LIPID RESEARCH

Combined effects of thePNPLA3rs738409,TM6SF2rs58542926, andMBOAT7rs641738 variants on NAFLD severity: a multicenter biopsy-based study

(2016) Marcin Krawczyk et al.   JOURNAL OF LIPID RESEARCH

Management of NAFLD: a stage-based approach

(2016) Mary E. Rinella et al.   Nature Reviews Gastroenterology & Hepatology

Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study

(2016) Anna Viitasalo et al.   PEDIATRIC RESEARCH

Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions

(2016) Robert N. Helsley et al.   STEM CELLS

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

(2016) Khaled Thabet et al.   Nature Communications

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation

(2016) Caleb C. Lord et al.   Cell Reports

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Lysophospholipid Acyltransferases Mediate Phosphatidylcholine Diversification to Achieve the Physical Properties Required In Vivo

(2014) Takeshi Harayama et al.   Cell Metabolism

Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells

(2014) Simona Zarini et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

(2013) Brian W. Parks et al.   Cell Metabolism

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP2 in the Mouse

(2013) Karen E. Anderson et al.   PLoS One

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

(2012) Anatole Ghazalpour et al.   MAMMALIAN GENOME

LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice

(2012) Hyeon-Cheol Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Non-contrasted Computed Tomography for the Accurate Measurement of Liver Steatosis in Obese Patients

(2011) Nathan J. Shores et al.   DIGESTIVE DISEASES AND SCIENCES

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

(2010) J. Mark Brown et al.   JOURNAL OF LIPID RESEARCH

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

(2010) Roger H. Unger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis

(2008) J. Mark Brown et al.   CIRCULATION

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

(2008) Miguel A. Gijón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss

(2008) J. Mark Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA:Lysophospholipid Acyltransferases

(2008) Hideo Shindou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular cloning of hamster lipid transfer inhibitor protein (apolipoprotein F) and regulation of its expression by hyperlipidemia

(2008) Lahoucine Izem et al.   JOURNAL OF LIPID RESEARCH

Recent progress on acyl CoA: lysophospholipid acyltransferase research

(2008) Hideo Shindou et al.   JOURNAL OF LIPID RESEARCH

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE