Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice

(2020) Qin Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism

(2020) Camille Attané et al.   Cell Reports

The role of metabolic lipases in the pathogenesis and management of liver disease

(2020) Matteo Tardelli et al.   HEPATOLOGY

Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer

(2019) Seher Balaban et al.   MOLECULAR CANCER RESEARCH

Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity

(2019) John D. Douglass et al.   JOURNAL OF LIPID RESEARCH

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

(2019) Matteo Tardelli et al.   JOURNAL OF LIPID RESEARCH

Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis

(2019) Matteo Tardelli et al.   HEPATOLOGY

Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

(2019) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

(2019) Ryan M. Wyatt et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs

(2018) Matteo Tardelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression

(2018) Wei Xiang et al.   Nature Communications

Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats

(2018) Martin A Sticht et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor–deficient mice

(2018) Kenji Yoshida et al.   FASEB JOURNAL

Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice

(2018) Yaqin Xiong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

(2018) Aida Habib et al.   GUT

Inhibition of monoacylglycerol lipase for the treatment of liver disease: tempting but still playing with fire

(2018) Claus Hellerbrand   GUT

Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling

(2017) Gernot F. Grabner et al.   PHARMACOLOGY & THERAPEUTICS

Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

(2016) Weiping Zhu et al.   Journal of Hematology & Oncology

Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors

(2016) Chien-Feng Li et al.   Oncotarget

Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma

(2016) Junyong Zhang et al.   Scientific Reports

Fatty Acid Signaling: The New Function of Intracellular Lipases

(2015) Zuzana Papackova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness

(2014) Cecilia Hillard et al.   CURRENT PHARMACEUTICAL DESIGN

Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial

(2014) Catherine Ouellette et al.   Lipids in Health and Disease

Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors

(2013) Micah J. Niphakis et al.   ACS Chemical Neuroscience

Monoacylglycerol Lipase Controls Endocannabinoid and Eicosanoid Signaling and Hepatic Injury in Mice

(2013) Zongxian Cao et al.   GASTROENTEROLOGY

Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice

(2013) Carolina Costola-de-Souza et al.   PLoS One

Monoacylglycerol lipase - a target for drug development?

(2012) CJ Fowler   BRITISH JOURNAL OF PHARMACOLOGY

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

(2012) Rongqing Chen et al.   Cell Reports

Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer

(2011) Lin Ye et al.   CANCER LETTERS

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis

(2011) Antonis D. Lampidonis et al.   GENE

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

(2010) Achim Lass et al.   PROGRESS IN LIPID RESEARCH

Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level

(2010) Olivier Harismendy et al.   GENOME BIOLOGY

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

(2009) Jonathan Z. Long et al.   CHEMISTRY & BIOLOGY

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

(2008) Yuguang Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract

(2008) Marnie Duncan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology