Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease

Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice

(2019) Meng Jiang et al.   BIOSCIENCE REPORTS

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

(2018) Maria Apostolopoulou et al.   DIABETES CARE

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis

(2018) Bianca Williams et al.   FASEB JOURNAL

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

(2018) Ian J. Neeland et al.   DIABETOLOGIA

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis

(2017) Xiaoyan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Role of ceramide in apoptosis and development of insulin resistance

(2016) D. I. Kuzmenko et al.   BIOCHEMISTRY-MOSCOW

Acid Sphingomyelinase Mediates Oxidized-LDL Induced Apoptosis in Macrophage via Endoplasmic Reticulum Stress

(2016) Min Zhao et al.   Journal of Atherosclerosis and Thrombosis

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

(2016) Peter J. Meikle et al.   Nature Reviews Endocrinology

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Sphingolipids and mitochondrial apoptosis

(2015) Gauri A. Patwardhan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Stress kinases in the modulation of metabolism and energy balance

(2015) Elisa Manieri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

(2015) Martin Pal et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vibrio vulnificus VvhA induces NF-κB-dependent mitochondrial cell death via lipid raft-mediated ROS production in intestinal epithelial cells

(2015) S-J Lee et al.   Cell Death & Disease

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

Anti-lipoapoptotic effect of Artemisia capillaris extract on free fatty acids-induced HepG2 cells

(2014) Eungyeong Jang et al.   BMC Complementary and Alternative Medicine

Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis

(2014) S C Cazanave et al.   CELL DEATH AND DIFFERENTIATION

Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes

(2014) Wei Pan et al.   CORONARY ARTERY DISEASE

Molecular mechanisms of hepatic apoptosis

(2014) K Wang   Cell Death & Disease

Ethanol extract of Cirsium japonicum attenuates hepatic lipid accumulation via AMPK activation in human HepG2 cells

(2014) YUN WAN et al.   Experimental and Therapeutic Medicine

Inhibition of ceramidede novosynthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

(2013) Krzysztof Kurek et al.   LIVER INTERNATIONAL

Role of ceramides in nonalcoholic fatty liver disease

(2012) Mangesh Pagadala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats

(2011) Li Chun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK

(2010) Alina Felicia Nica et al.   CELL CYCLE

Sphingolipids and insulin resistance: the five Ws

(2010) Scott A Summers   CURRENT OPINION IN LIPIDOLOGY

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS