Autophagy and the Hallmarks of Aging

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

Exosomes derived from miR-188-3p -modified adipose-derived mesenchymal stem cells protect Parkinson’s disease

(2021) Qiang Li et al.   Molecular Therapy-Nucleic Acids

Stem cell quiescence: the challenging path to activation

(2021) Noelia Urbán et al.   DEVELOPMENT

Exosomes produced by adipose-derived stem cells inhibit schwann cells autophagy and promote the regeneration of the myelin sheath

(2021) Gang Yin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Crosstalk between exosomes and autophagy: A review of molecular mechanisms and therapies

(2021) Huifang Xing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Causes and consequences of DNA damage-induced autophagy

(2021) Thomas Juretschke et al.   MATRIX BIOLOGY

The Regulation of ROS- and BECN1-Mediated Autophagy by Human Telomerase Reverse Transcriptase in Glioblastoma

(2021) Xuelu Ding et al.   Oxidative Medicine and Cellular Longevity

Beyond Autophagy: The Expanding Roles of ATG8 Proteins

(2021) Jose L. Nieto-Torres et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy

(2021) Chenxuan Wu et al.   Journal of Functional Foods

Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy

(2021) Daibang Nie et al.   Stem Cells International

The role of extracellular vesicles in podocyte autophagy in kidney disease

(2021) Baichao Sun et al.   Journal of Cell Communication and Signaling

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

(2021) Alexander Wirth et al.   GeroScience

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

(2021) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing

(2021) Yincong Zhang et al.   Nature Communications

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

An energetics perspective on geroscience: mitochondrial protonmotive force and aging

(2021) Brandon J. Berry et al.   GeroScience

Mechanisms of Selective Autophagy

(2021) Trond Lamark et al.   Annual Review of Cell and Developmental Biology

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

(2021) Jose L. Nieto-Torres et al.   CURRENT BIOLOGY

Reducing lipofuscin accumulation and cardiomyocytic senescence of aging heart by enhancing autophagy

(2021) Wen-wen Li et al.   EXPERIMENTAL CELL RESEARCH

Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats

(2021) Hassan Reda Hassan Elsayed et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair

(2021) Kelsey Erin Knewtson et al.   Tissue Engineering Part B-Reviews

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

(2021) Davide D’Amico et al.   TRENDS IN MOLECULAR MEDICINE

Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy

(2020) S. Joseph Endicott et al.   Autophagy

Sirtuins and the mitochondrial unfolded protein response.

(2020) Huidan Weng et al.   Current Neuropharmacology

Autophagy and Protein Secretion

(2020) Giulio Cavalli et al.   JOURNAL OF MOLECULAR BIOLOGY

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(2020) Sangwon Byun et al.   Nature Communications

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

(2020) Ting-Ting Xu et al.   Aging-US

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

(2020) Wenwen Liu et al.   Aging-US

Sex differences in autophagy-mediated diseases: toward precision medicine

(2020) Dangtong Shang et al.   Autophagy

Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy

(2020) Masahiro Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

(2020) Sandra Buratta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alzheimer’s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles

(2020) Xavier Gallart-Palau et al.   Alzheimers Research & Therapy

Sex differences in the response to oxidative and proteolytic stress

(2020) John Tower et al.   Redox Biology

Secretory Autophagy and Its Relevance in Metabolic and Degenerative Disease

(2020) Claudio Daniel Gonzalez et al.   Frontiers in Endocrinology

A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins

(2020) Steve Catarino et al.   Cells

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action

(2020) Federico Pietrocola et al.   Autophagy

The pluripotent role of exosomes in mediating non-coding RNA in ventricular remodeling after myocardial infarction

(2020) Zhongwen Qi et al.   LIFE SCIENCES

Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1

(2020) Woo Hyun Shin et al.   Cell Death & Disease

Autophagy Roles in Genome Maintenance

(2020) Susanna Ambrosio et al.   Cancers

Parkin Overexpression Alleviates Cardiac Aging through Facilitating K63-Polyubiquitination of TBK1 to Facilitate Mitophagy

(2020) Beilei Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy regulates exosome secretion in rat nucleus pulposus cells via the RhoC/ROCK2 pathway

(2020) Shun-Qi Hu et al.   EXPERIMENTAL CELL RESEARCH

Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response

(2020) Md. Abdul Hannan et al.   IMMUNOLOGY LETTERS

Inhibition of class I PI3K enhances chaperone-mediated autophagy

(2020) S. Joseph Endicott et al.   JOURNAL OF CELL BIOLOGY

The role of epigenetics and non-coding RNAs in autophagy: A new perspective for thorough understanding

(2020) Shahrzad Talebian et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SIRT1 is downregulated by autophagy in senescence and ageing

(2020) Caiyue Xu et al.   NATURE CELL BIOLOGY

Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice

(2020) Eui-Young So et al.   Aging-US

Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics

(2020) Tiejian Nie et al.   Autophagy

ATF4 ‐modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy

(2020) Yan Wang et al.   IUBMB LIFE

Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis

(2020) Wanghao Chen et al.   Molecular Therapy-Nucleic Acids

Facets of Autophagy Based Unconventional Protein Secretion–The Road Less Traveled

(2020) Sreedevi Padmanabhan et al.   Frontiers in Molecular Biosciences

Effects of caloric restriction on the antagonistic and integrative hallmarks of aging

(2020) Begun Erbaba et al.   AGEING RESEARCH REVIEWS

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy

(2019) Sijie Tan et al.   Scientific Reports

Suppression of autophagic activity by Rubicon is a signature of aging

(2019) Shuhei Nakamura et al.   Nature Communications

Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson’s disease

(2019) Liang Zhu et al.   Cell Death & Disease

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy

(2019) Paula Green et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

TORC1 specifically inhibits microautophagy through ESCRT-0

(2019) Riko Hatakeyama et al.   CURRENT GENETICS

Rapamycin activates mammalian microautophagy

(2019) Masahiro Sato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease

(2019) Richard I. Morimoto   Cold Spring Harbor Perspectives in Biology

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila

(2019) Joseph M. Schinaman et al.   Scientific Reports

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

(2019) Daniel Moreno-Blas et al.   Aging-US

Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults

(2019) Corey R. Hart et al.   Aging-US

Emerging lysosomal pathways for quality control at the endoplasmic reticulum

(2019) Chiara De Leonibus et al.   FEBS LETTERS

Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy

(2019) Rut Valdor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

(2019) Alicia Mayeuf-Louchart et al.   Cell Reports

Effects of Intermittent Fasting on Health, Aging, and Disease

(2019) Rafael de Cabo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

The ATG conjugation systems in autophagy

(2019) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging

(2018) Eloy Bejarano et al.   AGING CELL

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The potentially conflicting cell autonomous and cell non-autonomous functions of autophagy in mediating tumor response to cancer therapy

(2018) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

(2018) Miriam Toledo et al.   Cell Metabolism

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

(2018) Patricia Boya et al.   DEVELOPMENT

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

Ten-eleven translocation 1 regulates methylation of autophagy-related genes in human glioma

(2018) Rui Fu et al.   NEUROREPORT

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

(2018) Shigeto Sato et al.   Scientific Reports

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

(2018) Erin E. Congdon   Frontiers in Neuroscience

Metformin as geroprotector: experimental and clinical evidence

(2018) Veronika Piskovatska et al.   BIOGERONTOLOGY

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Towards Understanding Genomic Instability, Mitochondrial Dysfunction and Aging

(2018) Nima B Fakouri et al.   FEBS Journal

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

(2018) Kurt A. Escobar et al.   AGING CELL

Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians

(2018) Fu-Hui Xiao et al.   GENOME RESEARCH

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

(2018) Isaac Tamargo-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Noncanonical autophagy at ER exit sites regulates procollagen turnover

(2018) Shakib Omari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

(2018) Ryan O. Walters et al.   Cell Reports

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

Humanin is an endogenous activator of chaperone-mediated autophagy

(2017) Zhenwei Gong et al.   JOURNAL OF CELL BIOLOGY

Shaping proteostasis at the cellular, tissue, and organismal level

(2017) Ambre J. Sala et al.   JOURNAL OF CELL BIOLOGY

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

(2017) Yotam Raz et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

(2017) Chensu Wang et al.   Nature Communications

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

(2017) Caroline Kumsta et al.   Nature Communications

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

(2017) Babette C. Hammerling et al.   Nature Communications

Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms

(2017) Martin Madill et al.   Molecular Brain

The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan

(2017) Justin Minnerly et al.   PLoS Genetics

AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

(2017) Arnold Y Seo et al.   eLife

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Doxycycline Induces Mitophagy and Suppresses Production of Interferon-β in IPEC-J2 Cells

(2017) Yang Xing et al.   Frontiers in Cellular and Infection Microbiology

Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue

(2017) Sang-Nam Kim et al.   Scientific Reports

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

(2016) Amiya Kumar Ghosh et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model

(2016) Sribalasubashini Muralimanoharan et al.   Autophagy

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7

(2016) Bao Wang et al.   Autophagy

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Selective endosomal microautophagy is starvation-inducible in Drosophila

(2016) Anindita Mukherjee et al.   Autophagy

Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1

(2016) Muhammad Ali et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

(2016) Sarah J. Mitchell et al.   Cell Metabolism

Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease

(2016) Alice Nardin et al.   Current Neuropharmacology

Aging is associated with hypermethylation of autophagy genes in macrophages

(2016) Hany Khalil et al.   Epigenetics

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles

(2016) Rosalind F. Roberts et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

(2016) Chunya Ni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functions of Polyamines in Mammals

(2016) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

(2016) Sebastian I. Arriola Apelo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62

(2016) Yanan Wang et al.   MOLECULAR CELL

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

(2016) Beth Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis

(2016) P Fortini et al.   Cell Death & Disease

MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence

(2016) Jia-an Zhang et al.   Oncotarget

Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE−/− mice

(2016) Juan Peng et al.   Oncotarget

Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia

(2016) Sarah M. Guadiana et al.   Frontiers in Aging Neuroscience

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

(2016) Yongmei Qi et al.   Scientific Reports

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

(2015) Jaime L. Schneider et al.   AGING CELL

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

(2015) Fu-Zheng Wei et al.   Autophagy

Autophagy Regulatory Network — A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy

(2015) Dénes Türei et al.   Autophagy

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

(2015) Tania Martins-Marques et al.   BIOCHEMICAL JOURNAL

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans

(2015) Alfonso Schiavi et al.   CURRENT BIOLOGY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein modification and maintenance systems as biomarkers of ageing

(2015) Valerie Vanhooren et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

Activation of the unfolded protein response in aged human lenses

(2015) HE-ZHEN TANG et al.   Molecular Medicine Reports

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

Autophagy suppresses melanoma tumorigenesis by inducing senescence

(2014) He Liu et al.   Autophagy

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity

(2014) Loretta Breslin et al.   CELL CYCLE

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

(2014) Daniel A. East et al.   CHEMISTRY & BIOLOGY

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1

(2014) Su Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Connexins modulate autophagosome biogenesis

(2014) Eloy Bejarano et al.   NATURE CELL BIOLOGY

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians

(2014) Enzo Emanuele et al.   REJUVENATION RESEARCH

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

(2014) John J. Lemasters   Redox Biology

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

(2013) A. Artal-Martinez de Narvajas et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

(2013) Jaime Anguiano et al.   Nature Chemical Biology

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

(2013) Jonathan Zirin et al.   PLOS BIOLOGY

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress

(2012) Kamini Singh et al.   Autophagy

Caspase activation regulates the extracellular export of autophagic vacuoles

(2012) Isabelle Sirois et al.   Autophagy

Subversion of Autophagy by Kaposi's Sarcoma-Associated Herpesvirus Impairs Oncogene-Induced Senescence

(2012) Andrew M. Leidal et al.   Cell Host & Microbe

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

Impaired Heat Shock Response in Cells Expressing Full-Length Polyglutamine-Expanded Huntingtin

(2012) Sidhartha M. Chafekar et al.   PLoS One

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spermidine and Spermine Are Enriched in Whole Blood of Nona/Centenarians

(2012) Stefania Pucciarelli et al.   REJUVENATION RESEARCH

Age-Related Oxidative Stress Compromises Endosomal Proteostasis

(2012) Elvira S. Cannizzo et al.   Cell Reports

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1

(2011) Sixin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

(2011) T. Yahata et al.   BLOOD

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Autophagy: a pathway that contributes to connexin degradation

(2011) A. Lichtenstein et al.   JOURNAL OF CELL SCIENCE

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

(2011) Hiroshi Koga et al.   Nature Communications

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Piecemeal Microautophagy of the Nucleus Requires the Core Macroautophagy Genes

(2008) R. Krick et al.   MOLECULAR BIOLOGY OF THE CELL

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics