Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 21, Pages 8638-8643
Publisher
Proceedings of the National Academy of Sciences
Online
2013-05-07
DOI
10.1073/pnas.1216197110
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The pathways of mitophagy for quality control and clearance of mitochondria
- (2012) G Ashrafi et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial quality control: a matter of life and death for neurons
- (2012) Elena I Rugarli et al. EMBO JOURNAL
- Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan
- (2012) A.M. Todd et al. GENETICS AND MOLECULAR RESEARCH
- Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
- (2012) Minjuan Bian et al. PLoS One
- Expression of Yeast NDI1 Rescues a Drosophila Complex I Assembly Defect
- (2012) Jaehyoung Cho et al. PLoS One
- Mitochondrial Fission, Fusion, and Stress
- (2012) R. J. Youle et al. SCIENCE
- Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan
- (2011) Pedro Reis-Rodrigues et al. AGING CELL
- Parkinson's Disease: Genetics and Pathogenesis
- (2011) Joshua M. Shulman et al. Annual Review of Pathology-Mechanisms of Disease
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
- (2011) Xinnan Wang et al. CELL
- Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
- (2011) Michael Rera et al. Cell Metabolism
- Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
- (2011) Nickie C. Chan et al. HUMAN MOLECULAR GENETICS
- How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?
- (2010) Elena Ziviani et al. Autophagy
- FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
- (2010) Fabio Demontis et al. CELL
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
- (2010) Matthew E. Gegg et al. HUMAN MOLECULAR GENETICS
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
- (2010) Atsushi Tanaka et al. JOURNAL OF CELL BIOLOGY
- Mechanisms of mitophagy
- (2010) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
- (2010) Angela C. Poole et al. PLoS One
- Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
- (2010) D.-F. Suen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- (2010) E. Ziviani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans
- (2010) Della C. David et al. PLOS BIOLOGY
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
- (2009) Daniel Finley Annual Review of Biochemistry
- The emerging complexity of protein ubiquitination
- (2009) David Komander BIOCHEMICAL SOCIETY TRANSACTIONS
- The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling
- (2009) Stefanie K Tiefenböck et al. EMBO JOURNAL
- The PINK1/Parkin pathway: a mitochondrial quality control system?
- (2009) Alexander J. Whitworth et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
- (2009) A. Ben-Zvi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
- (2009) C. Vives-Bauza et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search