Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function

(2020) Junying Wang et al.   Aging-US

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

(2020) Luca Liberale et al.   EUROPEAN HEART JOURNAL

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

(2020) Madalina Filfan et al.   GeroScience

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

(2019) Min Chai et al.   Cell Reports

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

(2019) Luke S. Tain et al.   AGING CELL

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

Mice with hyper-long telomeres show less metabolic aging and longer lifespans

(2019) Miguel A. Muñoz-Lorente et al.   Nature Communications

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

(2019) Marta Maglione et al.   Scientific Reports

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

(2018) Claudia Schwarz et al.   Aging-US

Short telomeres — A hallmark of heritable cardiomyopathies

(2018) Alex C.Y. Chang et al.   DIFFERENTIATION

PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase

(2018) Wareed Ahmed et al.   GENES & DEVELOPMENT

Role of hypothalamus in aging and its underlying cellular mechanisms

(2018) Keetae Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture

(2018) Chiara Parodi et al.   PLOS BIOLOGY

Telomere length measurement as a clinical biomarker of aging and disease

(2018) Clare L. Fasching   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Caloric Restriction Promotes Structural and Metabolic Changes in the Skin

(2017) Maria Fernanda Forni et al.   Cell Reports

Structural and Functional Changes With the Aging Kidney

(2016) Aleksandar Denic et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging

(2016) Jatta S Takkinen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Does Longer Lifespan Mean Longer Healthspan?

(2016) Malene Hansen et al.   TRENDS IN CELL BIOLOGY

Pathology of Mouse Models of Accelerated Aging

(2016) L. Harkema et al.   VETERINARY PATHOLOGY

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

(2016) Varun K. Gupta et al.   PLOS BIOLOGY

Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell

(2015) Leonor Miller-Fleming et al.   JOURNAL OF MOLECULAR BIOLOGY

Selected Disorders of Skin Appendages—Acne, Alopecia, Hyperhidrosis

(2015) Jay C. Vary   MEDICAL CLINICS OF NORTH AMERICA

Three Members of Polyamine Modulon under Oxidative Stress Conditions: Two Transcription Factors (SoxR and EmrR) and a Glutathione Synthetic Enzyme (GshA)

(2015) Akihiko Sakamoto et al.   PLoS One

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Oxidative Stress in Cardiovascular Disease

(2014) Gábor Csányi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caloric restriction mimetics: towards a molecular definition

(2014) Frank Madeo et al.   NATURE REVIEWS DRUG DISCOVERY

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

(2014) Christian Bär et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence

(2013) Zhou Xu et al.   GENETICS

Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model

(2013) S. L. Thorn et al.   JOURNAL OF NUCLEAR MEDICINE

Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity

(2013) Elsa Vera et al.   PLoS One

Association of telomere shortening in myocardium with heart weight gain and cause of death

(2013) Masanori Terai et al.   Scientific Reports

The Rate of Increase of Short Telomeres Predicts Longevity in Mammals

(2012) Elsa Vera et al.   Cell Reports

A stabilizing and denaturing dual-effect for natural polyamines interacting with G-quadruplexes depending on concentration

(2011) Hongxia Sun et al.   BIOCHIMIE

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

(2011) Yuval Ramot et al.   PLoS One

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

(2011) James B. Strait et al.   Heart Failure Clinics

Spermidine: A novel autophagy inducer and longevity elixir

(2010) Frank Madeo et al.   Autophagy

Age-Dependent Changes in the Kidney Morphology of Female DBA/2 Mice

(2009) Akira YABUKI et al.   EXPERIMENTAL ANIMALS

Polyamines: Potential anti-inflammatory agents and their possible mechanism of action

(2009) SureshRamnath Naik et al.   INDIAN JOURNAL OF PHARMACOLOGY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Incident Heart Failure Prediction in the Elderly

(2008) Javed Butler et al.   Circulation-Heart Failure