Reducing lipofuscin accumulation and cardiomyocytic senescence of aging heart by enhancing autophagy

Targeting Age-Related Pathways in Heart Failure

(2020) Haobo Li et al.   CIRCULATION RESEARCH

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

(2019) Ellen Quarles et al.   AGING CELL

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

(2018) Gabriele Civiletto et al.   EMBO Molecular Medicine

Mechanisms driving the ageing heart

(2017) Rhys Anderson et al.   EXPERIMENTAL GERONTOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Aging and Autophagy in the Heart

(2016) Akihiro Shirakabe et al.   CIRCULATION RESEARCH

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade

(2013) Kalkidan Bishu et al.   PLoS One

Mitochondria and Cardiovascular Aging

(2012) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging

(2012) Debapriya Dutta et al.   CIRCULATION RESEARCH

Advanced glycation end products and lipofuscin deposits share the same location in cardiocytes of the failing heart

(2012) Jerzy Nozynski et al.   EXPERIMENTAL GERONTOLOGY

Increased lipofuscin on endomyocardial biopsy predicts greater cardiac improvement in adolescents and young adults

(2011) Susan J. Parson et al.   CARDIOVASCULAR PATHOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Sometimes Sperm Whales (Physeter macrocephalus) Cannot Find Their Way Back to the High Seas: A Multidisciplinary Study on a Mass Stranding

(2011) Sandro Mazzariol et al.   PLoS One

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease

(2010) Jun Ren et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Increased Oxidative Stress and Cardiomyocyte Myofibrillar Degeneration in Patients With Chronic Isolated Mitral Regurgitation and Ejection Fraction >60%

(2010) Mustafa I. Ahmed et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

New Insights Into Cardiac Aging

(2009) Anthony J. Muslin   CIRCULATION

Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

(2009) Yasutaka Inuzuka et al.   CIRCULATION

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Myocardial lipofuscin-laden lysosomes contain the apoptosis marker caspase-cleaved cytokeratin-18

(2008) A. Soleiman et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION