Causes and consequences of DNA damage-induced autophagy

DNA–protein crosslink proteases in genome stability

(2021) Annamaria Ruggiano et al.   Communications Biology

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

(2021) Susanne Zellner et al.   MOLECULAR CELL

Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes

(2020) Katsunori Hase et al.   Autophagy

DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy

(2020) Pietri Puustinen et al.   Autophagy

Selective autophagy degrades nuclear pore complexes

(2020) Chia-Wei Lee et al.   NATURE CELL BIOLOGY

CHK2-FOXK axis promotes transcriptional control of autophagy programs

(2020) Yuping Chen et al.   Science Advances

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

(2020) Satoru Torii et al.   Nature Communications

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

(2020) John Fielden et al.   Nature Communications

Differential activation of eMI by distinct forms of cellular stress

(2020) Ana Mesquita et al.   Autophagy

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration

(2020) Hirofumi Yamaguchi et al.   Nature Communications

Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

(2020) Sapir Schlam‐Babayov et al.   EMBO JOURNAL

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

(2019) Yuk Yuen Lan et al.   AGING CELL

DNA damage kinase signaling: checkpoint and repair at 30 years

(2019) Michael Charles Lanz et al.   EMBO JOURNAL

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination

(2018) Arishya Sharma et al.   Autophagy

mTORC1 pathway in DNA damage response

(2018) Yinxing Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

(2018) Mingdong Liu et al.   Nature Communications

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

(2018) Eutteum Jeong et al.   eLife

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

(2017) François Le Guerroué et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Poly-ADP ribosylation in DNA damage response and cancer therapy

(2017) Wei-Hsien Hou et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria response to camptothecin and hydroxycamptothecine-induced apoptosis in Spodoptera exigua cells

(2017) Xiaoshuang Ren et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

A pathway of targeted autophagy is induced by DNA damage in budding yeast

(2017) Vinay V. Eapen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

Retrograde signaling from autophagy modulates stress responses

(2017) Hans-Uwe Simon et al.   Science Signaling

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

(2017) Diletta Edifizi et al.   Cell Reports

Retrograde signaling from autophagy modulates stress responses

(2017) Hans-Uwe Simon et al.   Science Signaling

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

(2017) Shih-Chieh Chiang et al.   Science Advances

Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes

(2016) Shu Aizawa et al.   Autophagy

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

(2016) Graeme Hewitt et al.   Autophagy

Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes

(2016) Shu Aizawa et al.   Autophagy

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export

(2016) José M Rodríguez-Vargas et al.   CELL DEATH AND DIFFERENTIATION

Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagy

(2016) Satoru Torii et al.   EMBO REPORTS

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

(2016) Olufolake Akinduro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62

(2016) Yanan Wang et al.   MOLECULAR CELL

An evolutionarily conserved pathway controls proteasome homeostasis

(2016) Adrien Rousseau et al.   NATURE

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Lysosomal recruitment of TSC2 is a universal response to cellular stress

(2016) Constantinos Demetriades et al.   Nature Communications

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

(2016) Yongmei Qi et al.   Scientific Reports

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding

(2015) Yuuki Fujiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

(2015) Katsunori Hase et al.   NUCLEIC ACIDS RESEARCH

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

(2014) Min Peng et al.   CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Discovery of a novel type of autophagy targeting RNA

(2013) Yuuki Fujiwara et al.   Autophagy

Direct uptake and degradation of DNA by lysosomes

(2013) Yuuki Fujiwara et al.   Autophagy

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

(2013) Dipak Maskey et al.   Nature Communications

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis

(2012) Lingyu Luo et al.   CANCER LETTERS

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

A Late Form of Nucleophagy in Saccharomyces cerevisiae

(2012) Dalibor Mijaljica et al.   PLoS One

PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent

(2012) Chantal Éthier et al.   PLoS One

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Filamin-A as a marker and target for DNA damage based cancer therapy

(2011) Jingyin Yue et al.   DNA REPAIR

Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase 1

(2011) M. Dyavaiah et al.   MOLECULAR CANCER RESEARCH

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage

(2010) Petra Groth et al.   JOURNAL OF MOLECULAR BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

PARP-1 is involved in autophagy induced by DNA damage

(2009) José Antonio Muñoz-Gámez et al.   Autophagy

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Piecemeal Microautophagy of the Nucleus Requires the Core Macroautophagy Genes

(2008) R. Krick et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY