Facets of Autophagy Based Unconventional Protein Secretion–The Road Less Traveled

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

LC3-dependent extracellular vesicle loading and secretion (LDELS)

(2020) Andrew M. Leidal et al.   Autophagy

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

(2020) Min Zhang et al.   CELL

Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1

(2020) David Cruz-Garcia et al.   JOURNAL OF CELL BIOLOGY

Secretory Autophagy and Its Relevance in Metabolic and Degenerative Disease

(2020) Claudio Daniel Gonzalez et al.   Frontiers in Endocrinology

A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins

(2020) Steve Catarino et al.   Cells

Protein translocation into the ERGIC: an upstream event of secretory autophagy

(2020) Lei Liu et al.   Autophagy

Autophagy-Dependent Secretion: Mechanism, Factors Secreted, and Disease Implications

(2019) Jacob New et al.   Autophagy

Unconventional Secretion Of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins In a Sirtuin-1 Dependent Manner

(2019) Ajeetha Josephrajan et al.   DIABETES

Unconventional secretion of α-Crystallin B requires the Autophagic pathway and is controlled by phosphorylation of its serine 59 residue

(2019) M. D’Agostino et al.   Scientific Reports

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators

(2018) Julian Nüchel et al.   Autophagy

Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR

(2018) Shin Hye Noh et al.   Autophagy

Unconventional protein secretion triggered by nutrient starvation

(2018) David Cruz-Garcia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease

(2018) Luigi Maiuri et al.   Aging-US

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy

(2018) Israel Cotzomi-Ortega et al.   MEDIATORS OF INFLAMMATION

A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1

(2017) David Cruz-Garcia et al.   JOURNAL OF CELL BIOLOGY

Unconventional secretion of FABP4 by endosomes and secretory lysosomes

(2017) Julien Villeneuve et al.   JOURNAL OF CELL BIOLOGY

Pathways of Unconventional Protein Secretion

(2017) Catherine Rabouille   TRENDS IN CELL BIOLOGY

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

(2016) Sung Min Son et al.   Autophagy

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of the fungal secretome

(2016) Sean W. McCotter et al.   CURRENT GENETICS

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

The unconventional secretion of ARMS2

(2016) Elod Kortvely et al.   HUMAN MOLECULAR GENETICS

Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR

(2016) Jiyoon Kim et al.   TRAFFIC

ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion

(2016) Amy J Curwin et al.   eLife

Secreted Acb1 Contributes to the Yeast-to-Hypha Transition in Cryptococcus neoformans

(2015) Xinping Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

IL13 activates autophagy to regulate secretion in airway epithelial cells

(2015) John D Dickinson et al.   Autophagy

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

(2015) Koichiro Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

(2015) Sung Min Son et al.   Molecular Neurodegeneration

ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function

(2015) Lyndsay Murrow et al.   NATURE CELL BIOLOGY

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages

(2014) T. Ohman et al.   JOURNAL OF IMMUNOLOGY

The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis

(2014) Y. Chen et al.   mBio

Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons

(2014) Nguyen-Vi Mohamed et al.   Scientific Reports

Contrasted evolutionary constraints on secreted and non-secreted proteomes of selected Actinobacteria

(2013) Subarna Thakur et al.   BMC GENOMICS

Unconventional protein secretion: an evolving mechanism

(2013) Vivek Malhotra   EMBO JOURNAL

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity in unconventional protein secretion

(2013) Catherine Rabouille et al.   JOURNAL OF CELL SCIENCE

Secretory versus Degradative Autophagy: Unconventional Secretion of Inflammatory Mediators

(2013) Shanya Jiang et al.   Journal of Innate Immunity

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

(2013) Takehiro Torisu et al.   NATURE MEDICINE

Vesicular transport earns a Nobel

(2013) Juan S. Bonifacino   TRENDS IN CELL BIOLOGY

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome

(2012) Jinkyo Suh et al.   BMC GENOMICS

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

(2012) Koutaro Ishibashi et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Constitutive secretion of tau protein by an unconventional mechanism

(2012) Xiyun Chai et al.   NEUROBIOLOGY OF DISEASE

Tau Overexpression Results in Its Secretion via Membrane Vesicles

(2012) Diana Simón et al.   Neurodegenerative Diseases

Rescue of ΔF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway

(2011) Heon Yung Gee et al.   CELL

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

(2011) Caroline Bruns et al.   JOURNAL OF CELL BIOLOGY

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Role of autophagy in unconventional protein secretion

(2010) Ravi Manjithaya et al.   Autophagy

Pregnenolone Sulfate and Cortisol Induce Secretion of Acyl-CoA-binding Protein and Its Conversion into Endozepines from Astrocytes

(2010) William F. Loomis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Unconventional secretion ofPichia pastorisAcb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation

(2010) Ravi Manjithaya et al.   JOURNAL OF CELL BIOLOGY

Autophagy: a broad role in unconventional protein secretion?

(2010) Ravi Manjithaya et al.   TRENDS IN CELL BIOLOGY

The rapid evolution of signal peptides is mainly caused by relaxed selection on non-synonymous and synonymous sites

(2009) Yu-Dong Li et al.   GENE

Functional role of Alix in HIV-1 replication

(2009) Ken Fujii et al.   VIROLOGY

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

dGRASP-Mediated Noncanonical Integrin Secretion Is Required for Drosophila Epithelial Remodeling

(2008) Hans Schotman et al.   DEVELOPMENTAL CELL

Rerouting of fibroblast growth factor 2 to the classical secretory pathway results in post-translational modifications that block binding to heparan sulfate proteoglycans

(2008) Sabine Wegehingel et al.   FEBS LETTERS