Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
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Title
Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
Authors
Keywords
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Journal
Scientific Reports
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-05-24
DOI
10.1038/s41598-019-44106-5
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Note: Only part of the references are listed.- Autophagy as a promoter of longevity: insights from model organisms
- (2018) Malene Hansen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2017) Patrick Smith et al. eLife
- The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
- (2016) Brian K. Kennedy et al. Cell Metabolism
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- (2016) Martin Resnik-Docampo et al. NATURE CELL BIOLOGY
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- (2016) Matthew A. Odenwald et al. Nature Reviews Gastroenterology & Hepatology
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- (2016) Alessandro Bitto et al. eLife
- A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans
- (2016) Amit Khanna et al. Scientific Reports
- Healthy aging: The ultimate preventative medicine
- (2015) M. Kaeberlein et al. SCIENCE
- Gut microbiota and aging
- (2015) P. W. OToole et al. SCIENCE
- Rapamycin preserves gut homeostasis during Drosophila aging
- (2015) Xiaolan Fan et al. Oncotarget
- Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality
- (2015) Rebecca I. Clark et al. Cell Reports
- Microbes Promote Amino Acid Harvest to Rescue Undernutrition in Drosophila
- (2015) Ryuichi Yamada et al. Cell Reports
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- (2014) Dao-Fu Dai et al. AGING CELL
- You Are What You Host: Microbiome Modulation of the Aging Process
- (2014) Caroline Heintz et al. CELL
- PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
- (2014) Linlin Guo et al. CELL
- Exploring the physiology and pathology of aging in the intestine ofDrosophila melanogaster
- (2014) Heinrich Jasper INVERTEBRATE REPRODUCTION & DEVELOPMENT
- Gut microbiota dictates the metabolic response of Drosophila to diet
- (2014) A. C.- N. Wong et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Medical research: Treat ageing
- (2014) Luigi Fontana et al. NATURE
- Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology
- (2014) N. A. Broderick et al. mBio
- The role of protein clearance mechanisms in organismal ageing and age-related diseases
- (2014) David Vilchez et al. Nature Communications
- AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner
- (2014) Matthew Ulgherait et al. Cell Reports
- Microbial shifts in the aging mouse gut
- (2014) Morgan GI Langille et al. Microbiome
- Late-life rapamycin treatment reverses age-related heart dysfunction
- (2013) James M. Flynn et al. AGING CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
- (2013) F. Demontis et al. Disease Models & Mechanisms
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
- (2013) A. Rana et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapamycin slows aging in mice
- (2012) John E. Wilkinson et al. AGING CELL
- Gut microbiota composition correlates with diet and health in the elderly
- (2012) Marcus J. Claesson et al. NATURE
- Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
- (2012) M. Rera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
- (2011) Smita Majumder et al. AGING CELL
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- (2011) Noboru Mizushima et al. Annual Review of Cell and Developmental Biology
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- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Aging as an Event of Proteostasis Collapse
- (2011) R. C. Taylor et al. Cold Spring Harbor Perspectives in Biology
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- (2010) Amanda M. Marchiando et al. Annual Review of Pathology-Mechanisms of Disease
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- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
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- (2010) Zhifen Yang et al. NATURE CELL BIOLOGY
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- (2010) Patricia Spilman et al. PLoS One
- Composition, variability, and temporal stability of the intestinal microbiota of the elderly
- (2010) M. J. Claesson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
- (2009) N. Buchon et al. GENES & DEVELOPMENT
- Effect of rapamycin on lifespan inDrosophila
- (2009) Benjamin Harrison et al. Geriatrics & Gerontology International
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
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