Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

GSA: Genome Sequence Archive *

(2017) Yanqing Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Whole-Genome Sequencing of a Healthy Aging Cohort

(2016) Galina A. Erikson et al.   CELL

The BIG Data Center: from deposition to integration to translation

(2016)   NUCLEIC ACIDS RESEARCH

Novel loci and pathways significantly associated with longevity

(2016) Yi Zeng et al.   Scientific Reports

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

REDD1 attenuates cardiac hypertrophy via enhancing autophagy

(2014) Chen Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research

(2014) João Pedro de Magalhães   CELL CYCLE

Studying aging in Drosophila

(2014) Ying He et al.   METHODS

Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians

(2014) Enzo Emanuele et al.   REJUVENATION RESEARCH

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Autophagy and cardiovascular aging

(2012) Sreejayan Nair et al.   CELL CYCLE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

RNA-sequence analysis of human B-cells

(2011) J. M. Toung et al.   GENOME RESEARCH

The Batten disease gene CLN3 is required for the response to oxidative stress

(2011) Richard I. Tuxworth et al.   HUMAN MOLECULAR GENETICS

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

Centenarians - a useful model for healthy aging? A 29-year follow-up of hospitalizations among 40 000 Danes born in 1905

(2009) Henriette Engberg et al.   AGING CELL

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH