Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

(2017) Thomas S. Randall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging

(2017) Ana M. Tormos et al.   PLoS One

Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency

(2016) Nobuyuki Kimura et al.   AMERICAN JOURNAL OF PATHOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

(2016) Sarah J. Mitchell et al.   Cell Metabolism

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Oligonol promotes anti-aging pathwaysviamodulation of SIRT1-AMPK-Autophagy Pathway

(2016) Seul-Ki Park et al.   Nutrition Research and Practice

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

(2016) Beth Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine

(2015) Ioana Alesutan et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma

(2015) Monica Venere et al.   Science Translational Medicine

Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration

(2015) Diana Wiesner et al.   HUMAN MOLECULAR GENETICS

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes

(2014) Meng-meng Fu et al.   DEVELOPMENTAL CELL

The interplay between mitochondria and autophagy and its role in the aging process

(2014) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes

(2014) Ming Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteasome Failure Promotes Positioning of Lysosomes around the Aggresome via Local Block of Microtubule-Dependent Transport

(2014) N. Zaarur et al.   MOLECULAR AND CELLULAR BIOLOGY

Connexins modulate autophagosome biogenesis

(2014) Eloy Bejarano et al.   NATURE CELL BIOLOGY

Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells

(2013) Denise Dietrich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Autophagy and microtubules - new story, old players

(2013) R. Mackeh et al.   JOURNAL OF CELL SCIENCE

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Inhibitory effect of intracellular lipid load on macroautophagy

(2010) Hiroshi Koga et al.   Autophagy

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons

(2010) Kiyoshi Katsumata et al.   Autophagy

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

(2010) Camille Geeraert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Multiple roles of the cytoskeleton in autophagy

(2009) Iryna Monastyrska et al.   BIOLOGICAL REVIEWS

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

(2009) Carla M. P. Cardoso et al.   PLoS One

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly

(2008) H. Toda et al.   GENES & DEVELOPMENT

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS