Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson’s disease

PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson's disease

(2017) Yasuo Miki et al.   NEUROSCIENCE LETTERS

Severe early-onset impulsive compulsive behavior and psychosis in PLA2G6 -related juvenile Parkinson's disease

(2017) T. Wirth et al.   PARKINSONISM & RELATED DISORDERS

Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons

(2017) Jiro Kawada et al.   Stem Cell Reports

Neuroaxonal dystrophy inPLA2G6knockout mice

(2015) Hisae Sumi-Akamaru et al.   NEUROPATHOLOGY

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

(2015) Ting Sun et al.   Nature Communications

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway

(2013) K.-S. Lee et al.   GENES & DEVELOPMENT

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells

(2013) Lamia'a Bahnassawy et al.   STEM CELLS AND DEVELOPMENT

Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells

(2012) Blake Byers et al.   Current Neurology and Neuroscience Reports

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease

(2010) Jun Peng et al.   AGING CELL

Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone

(2010) Momo Tani et al.   JOURNAL OF NEUROCHEMISTRY

The effect of drug treatment on neurogenesis in Parkinson's disease

(2010) Sean S. O'Sullivan et al.   MOVEMENT DISORDERS

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Induced pluripotent stem cells: opportunities as research and development tools in 21st century drug discovery

(2010) Rebecca K Rowntree et al.   Regenerative Medicine

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein

(2009) Franz Marxreiter et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase

(2009) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopaminergic Lesion Enhances Growth Factor-Induced Striatal Neuroblast Migration

(2009) Beate Winner et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Analysis of PArkin Co-Regulated Gene in a Taiwanese–Ethnic Chinese cohort with early-onset Parkinson's disease

(2009) Juliet M. Taylor et al.   PARKINSONISM & RELATED DISORDERS

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree

(2008) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain

(2008) Kate M. Brody et al.   BRAIN RESEARCH

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant α-synuclein exacerbates age-related decrease of neurogenesis

(2007) Beate Winner et al.   NEUROBIOLOGY OF AGING