Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases

Current progress in NK cell biology and NK cell-based cancer immunotherapy

(2020) Raquel Tarazona et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NK Cell Function Regulation by TGF-β-Induced Epigenetic Mechanisms

(2020) Stefano Regis et al.   Frontiers in Immunology

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

(2020) Emanuela Mensà et al.   Journal of Extracellular Vesicles

Exploiting the telomere machinery to put the brakes on inflamm-aging

(2020) Massimiliano Bonafè et al.   AGEING RESEARCH REVIEWS

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

The ECM path of senescence in aging: components and modifiers

(2020) Naama Levi et al.   FEBS Journal

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

(2020) Uddalak Bharadwaj et al.   PHARMACOLOGICAL REVIEWS

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10

(2020) Alessandra Zingoni et al.   Frontiers in Immunology

Natural Killer Cells: Tumor Surveillance and Signaling

(2020) Lizeth G. Meza Guzman et al.   Cancers

License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity

(2020) Angélica Díaz-Basabe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The interplay between immunosenescence and age-related diseases

(2020) Florencia Barbé-Tuana et al.   Seminars in Immunopathology

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases

(2020) Antero Salminen   JOURNAL OF MOLECULAR MEDICINE-JMM

NK cells expressing a chimeric activating receptor eliminate MDSCs and rescue impaired CAR-T cell activity against solid tumors

(2019) Robin Parihar et al.   Cancer Immunology Research

Failure of immunosurveillance accelerates aging

(2019) Maria Perez-Lanzon et al.   OncoImmunology

Tissue-resident cytotoxic innate lymphoid cells in tumor immunosurveillance

(2019) Efstathios G. Stamatiades et al.   SEMINARS IN IMMUNOLOGY

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients

(2019) Lin Xiao et al.   MOLECULAR THERAPY

Senescent cells: Living or dying is a matter of NK cells

(2019) Fabrizio Antonangeli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response

(2019) Elisabetta Vulpis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury

(2019) Alexander J. Davies et al.   CELL

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

(2019) Kimberley A. Wiggins et al.   AGING CELL

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging

(2019) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CD4+CD25+Foxp3+ regulatory T cells suppress NKG2D-mediated NK cell cytotoxicity in peripheral blood

(2019) Xu Geng et al.   MEDICINE

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

(2019) James Chapman et al.   FEBS LETTERS

Cellular Senescence and the Immune System in Cancer

(2019) Luis I. Prieto et al.   GERONTOLOGY

The role of elastin-derived peptides in human physiology and diseases

(2019) Aurélie Le Page et al.   MATRIX BIOLOGY

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

(2019) Dong Yang et al.   Journal for ImmunoTherapy of Cancer

Aging‐related carcinoembryonic antigen‐related cell adhesion molecule 1 signaling promotes vascular dysfunction

(2019) Florian Kleefeldt et al.   AGING CELL

Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy

(2019) Jinyu Zhang et al.   Journal for ImmunoTherapy of Cancer

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Cancer extracellular vesicles as novel regulators of NK cell response

(2019) Alessandra Soriani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

(2019) Mariya Lazarova et al.   Frontiers in Immunology

Activation of immunosuppressive network in the aging process

(2019) Antero Salminen   AGEING RESEARCH REVIEWS

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

(2018) Lucia Terlecki-Zaniewicz et al.   Aging-US

Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction

(2018) Santosh Karnewar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

Functions of NKG2D in CD8+ T cells: an opportunity for immunotherapy

(2018) Kushal Prajapati et al.   Cellular & Molecular Immunology

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging

(2018) Mladen Jergović et al.   EXPERIMENTAL GERONTOLOGY

Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders

(2018) Antero Salminen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Senescent cells: a therapeutic target for cardiovascular disease

(2018) Bennett G. Childs et al.   JOURNAL OF CLINICAL INVESTIGATION

Strategies targeting cellular senescence

(2018) Yossi Ovadya et al.   JOURNAL OF CLINICAL INVESTIGATION

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

(2018) Charles W. Frevert et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response—The final results of the D-first study

(2018) Yuho Najima et al.   LEUKEMIA RESEARCH

The Role of Immunosenescence in Neurodegenerative Diseases

(2018) Erica Costantini et al.   MEDIATORS OF INFLAMMATION

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

NKG2D and Its Ligands: “One for All, All for One”

(2018) Alessandra Zingoni et al.   Frontiers in Immunology

NKG2D: A Master Regulator of Immune Cell Responsiveness

(2018) Felix M. Wensveen et al.   Frontiers in Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion

(2018) Elena Lo Presti et al.   Frontiers in Immunology

TGFβ, smooth muscle cells and coronary artery disease: a review

(2018) Emma L. Low et al.   CELLULAR SIGNALLING

The p38-activated ER stress-ATF6α axis mediates cellular senescence

(2018) Hee Suk Kim et al.   FASEB JOURNAL

Immune cell subset differentiation and tissue inflammation

(2018) Pu Fang et al.   Journal of Hematology & Oncology

A possible mechanism of impaired NK cytotoxicity in cancer patients: Down-regulation of DAP10 by TGF-β1

(2018) June-Chul Lee et al.   TUMORI

The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10+ Regulatory T Cells During Acute Retroviral Infection

(2018) Elisabeth Littwitz-Salomon et al.   Frontiers in Immunology

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

(2018) Giada Amodio et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

GM-CSF therapy inhibits chronic graft-versus-host disease via expansion of regulatory T cells

(2018) Masaaki Hotta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The integration of inflammaging in age-related diseases

(2018) Tamas Fulop et al.   SEMINARS IN IMMUNOLOGY

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma

(2018) Susanne H. Baumeister et al.   Cancer Immunology Research

T Cells in Adipose Tissue in Aging

(2018) Antu Kalathookunnel Antony et al.   Frontiers in Immunology

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis

(2017) Rosa Molfetta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NKG2D ligand RAE1ε induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice

(2017) Li Qian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Diversity of tissue-resident NK cells

(2017) Hui Peng et al.   SEMINARS IN IMMUNOLOGY

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema

(2017) Xiao-Yu Cheng et al.   Oncotarget

Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases

(2017) Luca Parisi et al.   Journal of Immunology Research

Developmental and Functional Control of Natural Killer Cells by Cytokines

(2017) Yang Wu et al.   Frontiers in Immunology

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation

(2016) Burkhard Becher et al.   IMMUNITY

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility

(2016) Kensuke Shiraishi et al.   JOURNAL OF GASTROENTEROLOGY

Human CD56brightNK Cells: An Update

(2016) Tatiana Michel et al.   JOURNAL OF IMMUNOLOGY

M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner

(2016) Tamara Krneta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Myeloid-derived suppressor cells and tumor escape from immune surveillance

(2016) Viktor Umansky et al.   Seminars in Immunopathology

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

Human Circulating and Tissue-Resident CD56bright Natural Killer Cell Populations

(2016) Janine E. Melsen et al.   Frontiers in Immunology

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide

(2015) Ying Wang et al.   AGING CELL

Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

(2015) Paola Lucia Minciullo et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

Immunosuppression associated with chronic inflammation in the tumor microenvironment

(2015) Dingzhi Wang et al.   CARCINOGENESIS

Expansion of Myeloid-Derived Suppressor Cells in Patients with Acute Coronary Syndrome

(2015) Yan-ge Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts

(2015) Hui Zhang et al.   JOURNAL OF AUTOIMMUNITY

Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype

(2015) Gang Xiao et al.   Journal of Hematology & Oncology

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells

(2015) Alessandra Zingoni et al.   JOURNAL OF IMMUNOLOGY

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Senescence-associated inflammatory responses: aging and cancer perspectives

(2015) Audrey Lasry et al.   TRENDS IN IMMUNOLOGY

Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy

(2015) Cariad Chester et al.   Frontiers in Immunology

Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus

(2015) Jon Hazeldine et al.   Frontiers in Neurology

The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment

(2014) Savita Nair et al.   AGING CELL

Senescent cells: SASPected drivers of age-related pathologies

(2014) Yossi Ovadya et al.   BIOGERONTOLOGY

Regulatory T Cells and the Immune Aging Process: A Mini-Review

(2014) Ann Jagger et al.   GERONTOLOGY

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Regulatory NK Cells Suppress Antigen-Specific T Cell Responses

(2014) G. Deniz et al.   JOURNAL OF IMMUNOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8+ T Cells: Mechanism of Immune Evasion

(2014) Marie Lundholm et al.   PLoS One

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

The impact of ageing on natural killer cell function and potential consequences for health in older adults

(2013) Jon Hazeldine et al.   AGEING RESEARCH REVIEWS

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

(2013) Connie Jackaman et al.   AGING CELL

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

Tumor Microenvironmental Conversion of Natural Killer Cells into Myeloid-Derived Suppressor Cells

(2013) Y.-J. Park et al.   CANCER RESEARCH

Molecular mechanisms of natural killer cell activation in response to cellular stress

(2013) C J Chan et al.   CELL DEATH AND DIFFERENTIATION

Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy

(2013) Isabela Pedroza-Pacheco et al.   Cellular & Molecular Immunology

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling

(2013) Shuhei Hosomi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Host Environment Is Responsible for Aging-Related Functional NK Cell Deficiency

(2013) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

(2013) Chris P. Verschoor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications

(2013) G. Chitadze et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immunosurveillance as a regulator of tissue homeostasis

(2013) Laura Senovilla et al.   TRENDS IN IMMUNOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

(2012) Jon Hazeldine et al.   AGING CELL

Immunoregulatory Natural Killer Cells Suppress Autoimmunity by Down-Regulating Antigen-Specific CD8+T Cells in Mice

(2012) Margret Ehlers et al.   ENDOCRINOLOGY

DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+T and NK cells

(2012) Alba Fernández-Sánchez et al.   Epigenetics

Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response

(2012) Laura Brudecki et al.   INFECTION AND IMMUNITY

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Battle of the midgets

(2012) Shlomo Elias et al.   RNA Biology

New insights into chronic inflammation-induced immunosuppression

(2012) Julia Kanterman et al.   SEMINARS IN CANCER BIOLOGY

Age-related changes in CD8 T cell homeostasis and immunity to infection

(2012) Janko Nikolich-Žugich et al.   SEMINARS IN IMMUNOLOGY

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage

(2012) A-P Sappino et al.   Oncogenesis

Human NK cell lytic granules and regulation of their exocytosis

(2012) Konrad Krzewski et al.   Frontiers in Immunology

Regulation of immune cell function and differentiation by the NKG2D receptor

(2011) Biljana Zafirova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Age-related changes in natural killer cell receptors from childhood through old age

(2011) Aline Almeida-Oliveira et al.   HUMAN IMMUNOLOGY

NF-κB Regulates MICA Gene Transcription in Endothelial Cell through a Genetically Inhibitable Control Site

(2011) Da Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunosenescence of Human Natural Killer Cells

(2011) Inmaculada Gayoso et al.   Journal of Innate Immunity

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

TGF-  downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

(2011) C. A. Crane et al.   NEURO-ONCOLOGY

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

(2010) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands

(2010) Lola Fernández-Messina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Immature Myeloid Cells in Immune Senescence

(2010) E. Y. Enioutina et al.   JOURNAL OF IMMUNOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells

(2009) C. Cerboni et al.   BLOOD

Platelet-Derived Transforming Growth Factor-  Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity

(2009) H.-G. Kopp et al.   CANCER RESEARCH

C/EBPβ enhances NF–κB-associated signalling by reducing the level of IκB-α

(2009) Christian Cappello et al.   CELLULAR SIGNALLING

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+T cells during aging

(2009) Elaine Agius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence

(2009) Hanane Agherbi et al.   PLoS One

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

(2008) A. Soriani et al.   BLOOD

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

The NKG2D receptor: sensing stressed cells

(2008) Carlos López-Larrea et al.   TRENDS IN MOLECULAR MEDICINE