Functions of NKG2D in CD8+ T cells: an opportunity for immunotherapy

Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of rapamycin to alter murine effector CD8+T-cell differentiation

(2016) Bryan McQueen et al.   IMMUNOLOGY

CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata

(2016) Zhenpeng Dai et al.   JOURNAL OF IMMUNOLOGY

Regulation of NKG2D+CD8+ T-cell-mediated antitumor immune surveillance: Identification of a novel CD28 activation-mediated, STAT3 phosphorylation-dependent mechanism

(2016) Jiemiao Hu et al.   OncoImmunology

Strain-dependent Lethal Toxicity in NKG2D Ligand-targeted CAR T-cell Therapy

(2015) Rachel C Lynn et al.   MOLECULAR THERAPY

T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

(2015) Heather VanSeggelen et al.   MOLECULAR THERAPY

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

(2014) Luzhou Xing et al.   NATURE MEDICINE

Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

(2013) Gang Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

NKG2D Induces Mcl-1 Expression and Mediates Survival of CD8 Memory T Cell Precursors via Phosphatidylinositol 3-Kinase

(2013) F. M. Wensveen et al.   JOURNAL OF IMMUNOLOGY

NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp

(2013) Esther Serrano-Pertierra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phospholipase C 2 Plays a Role in TCR Signal Transduction and T Cell Selection

(2012) G. Fu et al.   JOURNAL OF IMMUNOLOGY

NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses

(2012) Andrew Zloza et al.   NATURE MEDICINE

Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: A potential pathogenic role in chronic inflammatory arthritis

(2011) Anna K. Andersson et al.   ARTHRITIS AND RHEUMATISM

Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+T cells and autoimmune vitiligo

(2011) Andrew Zloza et al.   AUTOIMMUNITY

NKG2D receptor regulates human effector T-cell cytokine production

(2011) A. Barber et al.   BLOOD

Treatment of multiple myeloma with adoptively transferred chimeric NKG2D receptor-expressing T cells

(2011) A Barber et al.   GENE THERAPY

Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction

(2011) Maya Caroline André et al.   INTERNATIONAL JOURNAL OF CANCER

Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses

(2011) K. Soderquest et al.   JOURNAL OF IMMUNOLOGY

Multiple Mechanisms Downstream of TLR-4 Stimulation Allow Expression of NKG2D Ligands To Facilitate Macrophage/NK Cell Crosstalk

(2010) P. Eissmann et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

(2010) Lynn Petukhova et al.   NATURE

An Enigmatic Tail of CD28 Signaling

(2010) J. S. Boomer et al.   Cold Spring Harbor Perspectives in Biology

Cytosolic PLA2is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

(2009) Fangming Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasome Regulation of ULBP1 Transcription

(2009) James E. Butler et al.   JOURNAL OF IMMUNOLOGY

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

(2009) Sung-Gyoo Park et al.   NATURE IMMUNOLOGY

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

Interferon-γ down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells

(2008) Nicole Schwinn et al.   INTERNATIONAL JOURNAL OF CANCER

NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain

(2008) Chandra Deb et al.   JOURNAL OF NEUROVIROLOGY

The expression and function of NKG2D molecule on intrahepatic CD8+ T cells in chronic viral hepatitis

(2008) P. T. F. Kennedy et al.   JOURNAL OF VIRAL HEPATITIS