NKG2D and Its Ligands: “One for All, All for One”

Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation

(2017) Shuhei Hosomi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A disease-linkedULBP6polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

(2017) Jianmin Zuo et al.   Science Signaling

In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells

(2017) Sayak Mukherjee et al.   Science Signaling

MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells

(2017) Christian Breunig et al.   Cell Death & Disease

Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

(2017) Jiaying Shen et al.   Cell Death & Disease

A disease-linkedULBP6polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

(2017) Jianmin Zuo et al.   Science Signaling

In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells

(2017) Sayak Mukherjee et al.   Science Signaling

5′-UTR and 3′-UTR Regulation of MICB Expression in Human Cancer Cells by Novel microRNAs

(2017) Wipaporn Wongfieng et al.   Genes

How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation

(2017) Fabrizio Antonangeli et al.   Frontiers in Immunology

Disarming Cellular Alarm Systems—Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses

(2017) Dominik Schmiedel et al.   Frontiers in Immunology

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

(2017) Elisabetta Vulpis et al.   OncoImmunology

Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy

(2016) Alessandra Zingoni et al.   CRITICAL REVIEWS IN IMMUNOLOGY

A short half-life of ULBP1 at the cell surface due to internalization and proteosomal degradation

(2016) Lola Fernández-Messina et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

(2016) Maria Pia Abruzzese et al.   Journal of Hematology & Oncology

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression

(2016) Benedetta Pignoloni et al.   JOURNAL OF IMMUNOLOGY

Alternative Splice Transcripts for MHC Class I–like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions

(2016) Pierre-Jean Gavlovsky et al.   JOURNAL OF IMMUNOLOGY

Regulation of NKG2D Expression and Signaling by Endocytosis

(2016) Rosa Molfetta et al.   TRENDS IN IMMUNOLOGY

The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB

(2016) Dominik Schmiedel et al.   eLife

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells

(2016) Alessandra Soriani et al.   OncoImmunology

Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells

(2016) Fabrizio Antonangeli et al.   OncoImmunology

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation

(2015) Antje Isernhagen et al.   EMBO Molecular Medicine

The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA

(2015) Antje Isernhagen et al.   IMMUNOGENETICS

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells

(2015) Alessandra Zingoni et al.   JOURNAL OF IMMUNOLOGY

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

(2015) W. Deng et al.   SCIENCE

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity

(2015) Alireza Labani-Motlagh et al.   TUMOR BIOLOGY

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

(2015) Cinzia Fionda et al.   Oncotarget

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

(2015) Benjamin G Gowen et al.   eLife

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

NKG2D Ligands in Tumor Immunity: Two Sides of a Coin

(2015) Jinyu Zhang et al.   Frontiers in Immunology

Effect of NKG2D ligand expression on host immune responses

(2015) Marine Champsaur et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape

(2015) Paula Codo et al.   Oncotarget

Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cell-mediated Lysis of Myeloma

(2015) Xiaosong Wu et al.   NEOPLASIA

RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma

(2014) Adeline R. Lam et al.   CANCER RESEARCH

Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression

(2014) Jingyan Xie et al.   Cellular & Molecular Immunology

c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells

(2014) Rosa Molfetta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

(2014) A Baragaño Raneros et al.   GENES AND IMMUNITY

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Down-Regulation of MHC Class I-Related Chain A on Tumor Cells by IFN- -Induced MicroRNA

(2014) D. Yadav et al.   JOURNAL OF IMMUNOLOGY

Intracellular Retention of the NKG2D Ligand MHC Class I Chain-Related Gene A in Human Melanomas Confers Immune Privilege and Prevents NK Cell-Mediated Cytotoxicity

(2014) M. B. Fuertes et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Metalloproteinase ADAM17/TNF- -Converting Enzyme Regulates Proteolytic Shedding of the MHC Class I-Related Chain B Protein

(2014) P. Boutet et al.   JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species– and DNA Damage Response–Dependent NK Cell Activating Ligand Upregulation Occurs at Transcriptional Levels and Requires the Transcriptional Factor E2F1

(2014) Alessandra Soriani et al.   JOURNAL OF IMMUNOLOGY

Altered MicroRNA Expression after Infection with Human Cytomegalovirus Leads to TIMP3 Downregulation and Increased Shedding of Metalloprotease Substrates, Including MICA

(2014) G. Esteso et al.   JOURNAL OF IMMUNOLOGY

Radiation-induced matrix metalloproteinases limit natural killer cell-mediated anticancer immunity in NCI-H23 lung cancer cells

(2014) WOONG HEO et al.   Molecular Medicine Reports

Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway

(2014) P. Vantourout et al.   Science Translational Medicine

Diversity and characterization of polymorphic 5′ promoter haplotypes of MICA and MICB genes

(2014) S. T. Cox et al.   TISSUE ANTIGENS

RNA-binding proteins regulate the expression of the immune activating ligand MICB

(2014) Daphna Nachmani et al.   Nature Communications

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells

(2014) Cristina Cerboni et al.   Frontiers in Immunology

Regulation of Fc Receptor Endocytic Trafficking by Ubiquitination

(2014) Rosa Molfetta et al.   Frontiers in Immunology

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

Soluble ligands for the NKG2D receptor are released during HIV-1 infection and impair NKG2D expression and cytotoxicity of NK cells

(2013) Giulia Matusali et al.   FASEB JOURNAL

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17

(2013) Guranda Chitadze et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell-Mediated Cytotoxicity in Multiple Myeloma Cells: Role of STAT3

(2013) C. Fionda et al.   JOURNAL OF IMMUNOLOGY

Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications

(2013) G. Chitadze et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition

(2012) Mary A. Markiewicz et al.   IMMUNITY

Histamine reduces susceptibility to natural killer cells via down-regulation of NKG2D ligands on human monocytic leukaemia THP-1 cells

(2012) Yasuhiro Nagai et al.   IMMUNOLOGY

RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry

(2012) Heiyoun Jung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive Analysis of NKG2D Ligand Expression and Release in Leukemia: Implications for NKG2D-Mediated NK Cell Responses

(2012) J. Hilpert et al.   JOURNAL OF IMMUNOLOGY

Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship

(2012) Giada Rossini et al.   MEDIATORS OF INFLAMMATION

Novel Role for STAT3 in Transcriptional Regulation of NK Immune Cell Targeting Receptor MICA on Cancer Cells

(2011) R. Bedel et al.   CANCER RESEARCH

Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2

(2011) S. Textor et al.   CANCER RESEARCH

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

(2011) A. Heinemann et al.   CANCER RESEARCH

Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide

(2011) I. B. Barsoum et al.   CANCER RESEARCH

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2

(2011) Hai Li et al.   CELL CYCLE

An Identical miRNA of the Human JC and BK Polyoma Viruses Targets the Stress-Induced Ligand ULBP3 to Escape Immune Elimination

(2011) Yoav Bauman et al.   Cell Host & Microbe

Post-transcriptional regulation of ULBP1 ligand for the activating immunoreceptor NKG2D involves 3′ untranslated region

(2011) Heike Himmelreich et al.   HUMAN IMMUNOLOGY

Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

(2011) Malin Hedlund et al.   PLoS One

Vesicular Stomatitis Virus Infection Promotes Immune Evasion by Preventing NKG2D-Ligand Surface Expression

(2011) Helle Jensen et al.   PLoS One

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations

(2010) Ayman Antoun et al.   HUMAN IMMUNOLOGY

Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl Ubiquitin Ligase

(2010) Hun Sik Kim et al.   IMMUNITY

Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands

(2010) Lola Fernández-Messina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases

(2010) G. Liu et al.   JOURNAL OF IMMUNOLOGY

The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination

(2010) Daphna Nachmani et al.   NATURE IMMUNOLOGY

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors

(2009) Y. T. Bryceson et al.   BLOOD

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells

(2009) C. Cerboni et al.   BLOOD

Diverse Herpesvirus MicroRNAs Target the Stress-Induced Immune Ligand MICB to Escape Recognition by Natural Killer Cells

(2009) Daphna Nachmani et al.   Cell Host & Microbe

ULBP6/RAET1L is an additional human NKG2D ligand

(2009) Robert A. Eagle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

(2009) I. Lee et al.   GENOME RESEARCH

Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells

(2009) Christine Sers et al.   INTERNATIONAL JOURNAL OF CANCER

The Traffic of the NKG2D/Dap10 Receptor Complex during Natural Killer (NK) Cell Activation

(2009) Pedro Roda-Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress

(2009) Timothy J. Nice et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brief Residence at the Plasma Membrane of the MHC Class I-Related Chain B Is Due to Clathrin-Mediated Cholesterol-Dependent Endocytosis and Shedding

(2009) S. Aguera-Gonzalez et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Protein-90 Inhibitors Increase MHC Class I-Related Chain A and B Ligand Expression on Multiple Myeloma Cells and Their Ability to Trigger NK Cell Degranulation

(2009) C. Fionda et al.   JOURNAL OF IMMUNOLOGY

Proteasome Regulation of ULBP1 Transcription

(2009) James E. Butler et al.   JOURNAL OF IMMUNOLOGY

HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer

(2009) A López-Soto et al.   ONCOGENE

Cellular Expression, Trafficking, and Function of Two Isoforms of Human ULBP5/RAET1G

(2009) Robert A. Eagle et al.   PLoS One

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

(2008) A. Soriani et al.   BLOOD

Hypoxia Increases Tumor Cell Shedding of MHC Class I Chain-Related Molecule: Role of Nitric Oxide

(2008) D. R. Siemens et al.   CANCER RESEARCH

Tumor-Associated MICA Is Shed by ADAM Proteases

(2008) I. Waldhauer et al.   CANCER RESEARCH

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

Four novel ULBP splice variants are ligands for human NKG2D

(2008) Wei Cao et al.   INTERNATIONAL IMMUNOLOGY

Modulation of natural killer cells by human cytomegalovirus

(2008) Gavin W.G. Wilkinson et al.   JOURNAL OF CLINICAL VIROLOGY

Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D

(2008) Noam Stern-Ginossar et al.   NATURE IMMUNOLOGY

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

(2008) M. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA