Article
Biochemistry & Molecular Biology
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Tong Liu
Summary: Oxidative stress and mitochondrial dysfunction play important roles in the development of diabetic cardiomyopathy in type 2 diabetes mellitus. This study established a type 2 diabetes model and found that inhibiting NADPH oxidase can improve ventricular remodeling and reduce the incidence of DCM.
Review
Biochemistry & Molecular Biology
Leticia Guadalupe Fragoso-Morales, Jose Correa-Basurto, Martha Cecilia Rosales-Hernandez
Summary: Alzheimer's disease is a major human dementia characterized by memory loss associated with oxidative stress in brain cells. Overexpression of NADPH oxidase in AD leads to the production of large amounts of reactive oxygen species, damaging brain cells and vasculature, making it a potential therapeutic target for AD.
Article
Cell Biology
Biljana Musicki, Serkan Karakus, Justin D. La Favor, Haolin Chen, Fabio H. Silva, Mikael Sturny, Barry R. Zirkin, Arthur L. Burnett
Summary: The study suggests that stimulating the production of endogenous testosterone can help reduce priapism in patients with SCD without affecting fertility. This treatment approach may work by activating TSPO, restoring phosphodiesterase 5 activity, and reducing oxidative stress levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Yuri Zilberter, Dennis R. Tabuena, Misha Zilberter
Summary: Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are difficult to treat due to a lack of understanding of their primary initiating factors. Recent research suggests that early oxidative stress caused by NADPH oxidase (NOX) activation may be a shared initiating mechanism among major sporadic NDDs. This study focuses on Alzheimer's disease (AD), Parkinson's disease (PD), and acquired epilepsy, and explores the commonalities in neuroinflammation and NOX involvement to identify therapeutic targets and gain a deeper understanding of the underlying causes of NDDs.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keum-Jin Yang, Won Jung Choi, Yoon-Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong
Summary: Xanthine oxidase (XO) inhibition showed renoprotective effects in diabetic kidney disease (DKD) by inhibiting vascular endothelial growth factor (VEGF) and NADPH oxidase (NOX) and reducing oxidative stress. This study provides important insights into the therapeutic potential of XO inhibition in DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Timothy Fabisiak, Manisha Patel
Summary: Neuroinflammation and oxidative stress play important roles in the pathophysiology of epilepsy. They have significant crosstalk and influence each other through various mechanisms, affecting epileptic processes and disease outcomes. Treatment strategies targeting oxidative stress and redox regulation may help control neuroinflammation and improve patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu, Adrian Manea
Summary: Dysregulated epigenetic mechanisms, specifically LSD1/KDM1A, play a crucial role in atherosclerosis by promoting oxidative stress and inflammation. Inhibition of LSD1 effectively reduces the extent of atherosclerotic lesions and decreases markers of immune cell infiltration and vascular inflammation, making it a potential therapeutic target.
Review
Biochemistry & Molecular Biology
Julio C. Padovan, Thales M. H. Dourado, Gustavo F. Pimenta, Thiago Bruder-Nascimento, Carlos R. Tirapelli
Summary: High consumption of ethanol increases the risk of cardiovascular diseases, particularly arterial hypertension. Ethanol-induced hypertension is a complex event involving oxidative stress as a hallmark of vascular dysfunction. Reactive oxygen species (ROS) play a crucial role in triggering various pathological processes, including intracellular calcium accumulation, reduced bioavailability of nitric oxide, activation of mitogen-activated protein kinases, endothelial dysfunction, and loss of the anticontractile effect of perivascular adipose tissue.
Article
Plant Sciences
Lei Liu, Yanchao Sun, Meijing Zhang, Ruixiang Liu, Xiaming Wu, Yanping Chen, Jianhua Yuan
Summary: This study found that BR treatment can increase the kinase activity of ZmBSK1, which in turn induces the production of H2O2. Specifically, ZmBSK1 regulates the gene expressions and activities of NADPH oxidases through phosphorylating ZmCCaMK. Genetic analysis also showed that the ZmBSK1-ZmCCaMK module enhances plant tolerance to oxidative stress induced by H2O2.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Saugat Shiwakoti, Ju-Young Ko, Dalseong Gong, Bikalpa Dhakal, Jeong-Hye Lee, Radhika Adhikari, Yeonhyang Gwak, Sin-Hee Park, Ik Jun Choi, Valerie B. Schini-Kerth, Ki-Woon Kang, Min-Ho Oak
Summary: Exposure to NPs may promote premature senescence of ECs, and this process is mediated in part by the oxidative stress-sensitive eNOS/Sirt1 signaling pathway. These findings provide insights into the effects and underlying mechanisms of NPs on the cardiovascular system, and offer potential pharmacological targets for preventing NPs-associated cardiovascular diseases.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Shouji Matsushima, Junichi Sadoshima
Summary: Oxidative stress plays a critical role in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression of Nox-derived ROS can prevent mitochondrial dysfunction and endoplasmic reticulum (ER) stress, leading to reduced myocardial I/R injury. However, minimal levels of ROS by either Nox2 or Nox4 are required for energy metabolism during I/R in order to preserve the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and peroxisome proliferator-activated receptor-alpha (PPAR alpha). Furthermore, extreme suppression of Nox activity may lead to reductive stress and paradoxical increases in ROS levels. Nox4 has different roles in organelles such as mitochondria, ER, and ER-mitochondria contact sites (MAMs). Mitochondrial Nox4 has a detrimental effect, causing ROS-induced mitochondrial dysfunction during I/R, whereas Nox4 in the ER and MAMs may potentially protect against I/R injury through regulation of autophagy and MAM function, respectively. Although Nox isoforms are potential therapeutic targets for I/R injury, it is important to optimize ROS levels and selectively inhibit Nox4 in mitochondria to maximize the effect of intervention.
Article
Biochemistry & Molecular Biology
Jin Han, Donghwi Park, Ji Young Park, Seungwoo Han
Summary: Increased oxidative stress in OA cartilage leads to extracellular matrix degradation and chondrocyte apoptosis. This study found that inhibiting NOX can decrease ROS production, suppress oxidative stress marker genes and catabolic proteases, and protect against OA by modulating oxidative stress and gene expression.
Article
Medicine, Research & Experimental
Ankit P. Laddha, Yogesh A. Kulkarni
Summary: The study focused on the effect of daidzein in an experimental model of diabetic cardiomyopathy in rats. Daidzein treatment improved cardiac function, restored ECG and hemodynamic parameters, prevented the loss of cardiac marker enzymes, and reduced cardiac tissue necrosis and fibrosis in diabetic rats, suggesting its potential in mitigating the progression of diabetic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Seiko Yamakoshi, Takahiro Nakamura, Lusi Xu, Masahiro Kohzuki, Osamu Ito
Summary: Exercise training can protect renal function in patients with chronic kidney disease by reducing the generation of reactive oxygen species.
Article
Chemistry, Medicinal
Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed, Eman K. Rashwan, Abdel-Gawad S. Shalkami, Ayman M. Mahmoud
Summary: The study showed that the natural NADPH oxidase inhibitor acetovanillone (AV) can protect rats from acute lung injury (ALI) induced by cyclophosphamide (CP) by attenuating oxidative stress and enhancing Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Antonia Giacco, Giuseppe delli Paoli, Rosalba Senese, Federica Cioffi, Elena Silvestri, Maria Moreno, Margherita Ruoppolo, Marianna Caterino, Michele Costanzo, Assunta Lombardi, Fernando Goglia, Antonia Lanni, Pieter de Lange
Article
Clinical Neurology
H. Kim, K. -J. Park, B. -K. Ryu, D. -H. Park, D. -S. Kong, K. Chong, Y. -S. Chae, Y. -G. Chung, S. I. Park, S. -H. Kang
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Min A. Seol, Jin-Hee Kim, Keunhee Oh, Gwanghun Kim, Myung Won Seo, Young-Kyoung Shin, Ji Hyun Sim, Hyun Mu Shin, Bo Yeon Seo, Dong-Sup Lee, Ja-Lok Ku, Ilkyu Han, Insoo Kang, Serk In Park, Hang-Rae Kim
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Jinho Kang, Yoon Ji Choi, Bo Yeon Seo, Ukhyun Jo, Serk In Park, Yeul Hong Kim, Kyong Hwa Park
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Kyung-Hun Lee, Kyoung Jin Lee, Tae-Yong Kim, Febby Hutomo, Hyun Jin Sun, Gi Jeong Cheon, Serk In Park, Sun Wook Cho, Seock-Ah Im
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Seung-Hoon Lee, Yeon-Ju Lee, Serk In Park, Jung-Eun Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Oncology
Young Mi Whang, Da Hyeon Yoon, Gwang Yong Hwang, Hoyub Yoon, Serk In Park, Young Wook Choi, In Ho Chang
Article
Multidisciplinary Sciences
Mini Jeong, Mi Hyeon Jeong, Jung Eun Kim, Serin Cho, Kyoung Jin Lee, Serkin Park, Jeongwon Sohn, Yun Gyu Park
Summary: The study reveals that the mTORC1/S6K pathway inhibits an Akt/PLK1 signaling axis, causing TCTP protein stabilization and conferring resistance to DNA-damaging agents in lung cancer cells. Inducing TCTP degradation with rapamycin enhances the efficacy of DNA-damaging drugs without consideration of p53 functional status.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Jeong-Ki Kim, Seong-Beom Han, Serk In Park, In-San Kim, Dong-Hwee Kim
Summary: Alternatively activated or M2 macrophages play a vital role in anti-inflammation, wound healing, and tissue repair. This study demonstrates that M2 activation requires mechanical cues from the extracellular microenvironment, and matrix rigidity-dependent macrophage spreading is mediated by F-actin formation. The study also identifies a new mechanosensing function of STAT6 in M2 activation.
Article
Biochemical Research Methods
Eun Jung Lee, Seungpil Jung, Kyong Hwa Park, Serk In Park
Summary: Multi-color flow cytometry is a standard approach in immunophenotyping clinical samples. This article describes a clinical study on quantifying MDSC in breast cancer patient blood samples and provides detailed procedures for study design, sample logistics and handling, staining, and flow cytometric analysis. The results of the study showed an increase in both PMN and M-MDSC populations in patients with bone metastasis. This work presents a versatile and practical protocol for measuring MDSC in patient blood samples.
JOURNAL OF IMMUNOLOGICAL METHODS
(2022)
Review
Endocrinology & Metabolism
Min-Kyoung Song, Serk In Park, Sun Wook Cho
Summary: Bone metastasis is a common site of spread for various solid tumors, leading to significant health problems and mortality in patients. One major challenge is the lack of biomarkers for early detection and monitoring of therapeutic responses. Current imaging techniques have limitations in detecting early lesions and accurately monitoring disease progression. Therefore, there is a need for the development of novel blood biomarkers. This review article provides an overview of the protein- and cell-based biomarkers that are currently used or under development for bone metastasis in clinical practice.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Cell & Tissue Engineering
Eun Jung Lee, Kyoung Jin Lee, Seungpil Jung, Kyong Hwa Park, Serk In Park
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells in the tumor microenvironment. The mechanism of MDSC mobilization from the bone marrow (BM) is still not fully understood. This study investigated the role of PTH1R activation in BM stromal cells in MDSC mobilization. It was found that PTH1R activation led to the release of monocytic (M-) MDSCs from murine BM by promoting binding between M-MDSCs and osteoblasts. The activation of Src family kinase and upregulation of proteases ADAM-17 and MMP7 were also involved in this process.
Review
Endocrinology & Metabolism
Rosalba Senese, Federica Cioffi, Giuseppe Petito, Fernando Goglia, Antonia Lanni