Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

Clinical Significance of the HLA-E and CD94/NKG2 Interaction

(2011) Milena Iwaszko et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers

(2011) Sarah E. Stewart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Human NKG2A overrides NKG2C effector functions to prevent autoreactivity of NK cells

(2011) V. Beziat et al.   BLOOD

Age-related changes in natural killer cell receptors from childhood through old age

(2011) Aline Almeida-Oliveira et al.   HUMAN IMMUNOLOGY

Human NK Cells Proliferate and Die In Vivo More Rapidly than T Cells in Healthy Young and Elderly Adults

(2011) C. T. Lutz et al.   JOURNAL OF IMMUNOLOGY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells

(2010) K. Juelke et al.   BLOOD

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

(2010) S. Lopez-Verges et al.   BLOOD

Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis

(2010) E. MARIANI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset

(2010) Richard P.G. Hayhoe et al.   HUMAN IMMUNOLOGY

Revisiting human natural killer cell subset function revealed cytolytic CD56dimCD16+ NK cells as rapid producers of abundant IFN-  on activation

(2010) A. De Maria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

(2009) J. Thiery et al.   BLOOD

Regulation of human NK-cell cytokine and chemokine production by target cell recognition

(2009) C. Fauriat et al.   BLOOD

Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions

(2009) Trinidad Garcia-Iglesias et al.   BMC CANCER

Human innate immunosenescence: causes and consequences for immunity in old age

(2009) Alexander Panda et al.   TRENDS IN IMMUNOLOGY

Innate immunity and aging

(2008) Christian R. Gomez et al.   EXPERIMENTAL GERONTOLOGY

JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity

(2008) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA