Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids

(2019) Oscar D. Murillo et al.   CELL

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

(2019) Mitsukuni Yoshida et al.   Cell Metabolism

Extracellular vesicles in human skin: cross-talk from senescent fibroblasts to keratinocytes by miRNAs

(2019) Lucia Terlecki-Zaniewicz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

(2019) Michela Borghesan et al.   Cell Reports

Lung cancer-derived extracellular vesicles induced myotube atrophy and adipocyte lipolysis via the extracellular IL-6-mediated STAT3 pathway

(2019) Wenjun Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Extracellular vesicles circulating in young organisms promote healthy longevity

(2019) Francesco Prattichizzo et al.   Journal of Extracellular Vesicles

Emerging roles of extracellular vesicles in cellular senescence and aging

(2018) Masaki Takasugi   AGING CELL

Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue ContractilityNovelty and Significance

(2018) Joshua Mayourian et al.   CIRCULATION RESEARCH

Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function

(2018) Yin Hu et al.   Theranostics

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Extracellular Vesicles Work as a Functional Inflammatory Mediator Between Vascular Endothelial Cells and Immune Cells

(2018) Baharak Hosseinkhani et al.   Frontiers in Immunology

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells

(2018) Angelica Giuliani et al.   Aging-US

Fibronectin on the Surface of Extracellular Vesicles Mediates Fibroblast Invasion

(2018) Diptiman Chanda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media

(2018) Brandon Lehrich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

The integration of inflammaging in age-related diseases

(2018) Tamas Fulop et al.   SEMINARS IN IMMUNOLOGY

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

(2018) Chulwoo Kim et al.   Cell Reports

Application of Small Epigenetic Modulators in Pediatric Medulloblastoma

(2018) Clemens Zwergel et al.   Frontiers in Pediatrics

Extracellular Vesicles Released by Oxidatively Injured or Intact C2C12 Myotubes Promote Distinct Responses Converging toward Myogenesis

(2017) Michele Guescini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging

(2017) Fabiola Olivieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Exosome-based immunomodulation during aging: A nano-perspective on inflamm-aging

(2017) Francesco Prattichizzo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

(2017) Erez Eitan et al.   Scientific Reports

Age-dependent expression ofDNMT1andDNMT3Bin PBMCs from a large European population enrolled in the MARK-AGE study

(2016) Fabio Ciccarone et al.   AGING CELL

Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells

(2016) Sylvia Weilner et al.   AGING CELL

Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathway

(2016) Ying Shao et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases

(2016) Carla Regina et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Extracellular RNA in aging

(2016) Douglas F. Dluzen et al.   Wiley Interdisciplinary Reviews-RNA

Local MicroRNA Modulation Using a Novel Anti-miR-21–Eluting Stent Effectively Prevents Experimental In-Stent RestenosisSignificance

(2015) Dong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21∗ in SCC progression

(2015) Yejing Ge et al.   NATURE CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small RNA-mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation

(2015) Guoqiang Zhang et al.   NUCLEIC ACIDS RESEARCH

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

Do age-associated DNA methylation changes increase the risk of malignant transformation?

(2014) Wolfgang Wagner et al.   BIOESSAYS

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan

(2013) Hanna Dellago et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

Low-level processing of Illumina Infinium DNA Methylation BeadArrays

(2013) Timothy J. Triche et al.   NUCLEIC ACIDS RESEARCH

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

The role of exosomes and microRNAs in senescence and aging

(2012) Dan Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

(2012) Fabiola Olivieri et al.   AGE

MicroRNA-10A* and MicroRNA-21 Modulate Endothelial Progenitor Cell Senescence Via Suppressing High-Mobility Group A2

(2012) Shoukang Zhu et al.   CIRCULATION RESEARCH

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

(2012) Fabiola Olivieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells

(2011) Céline Sabatel et al.   PLoS One

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms

(2009) Kyle Lafferty-Whyte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1

(2009) Rossella Menghini et al.   CIRCULATION

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE