T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

NKG2D-based chimeric antigen receptor therapy induced remission in a relapsed/refractory acute myeloid leukemia patient.

(2018) David A. Sallman et al.   HAEMATOLOGICA

NKG2D ligands in glioma stem-like cells: expression in situ and in vitro

(2018) Charlotte Flüh et al.   HISTOCHEMISTRY AND CELL BIOLOGY

CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges

(2018) Stephen J Bagley et al.   NEURO-ONCOLOGY

Chimeric antigen receptor T-cell immunotherapy for glioblastoma: practical insights for neurosurgeons

(2018) Bryan D. Choi et al.   Neurosurgical Focus

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

(2018) Lucas Ferrari de Andrade et al.   SCIENCE

HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53

(2018) Dong Yang et al.   Theranostics

NKG2D-based chimeric antigen receptor therapy induced remission in a relapsed/refractory acute myeloid leukemia patient.

(2018) David A. Sallman et al.   HAEMATOLOGICA

Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

(2017) Delphine Garnier et al.   NEURO-ONCOLOGY

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Chimeric antigen receptor T-cell therapy for glioblastoma

(2017) Analiz Rodriguez et al.   Translational Research

Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment

(2017) Yelei Guo et al.   Protein & Cell

Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo

(2017) Yanjing Song et al.   Protein & Cell

HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma

(2017) Nabil Ahmed et al.   JAMA Oncology

Chimeric antigen receptors for treatment of glioblastoma: a practical review of challenges and ways to overcome them

(2016) S Sengupta et al.   CANCER GENE THERAPY

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

(2016) Christine E. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire

(2016) Jennifer S. Sims et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive T-cell therapy of prostate cancer targeting the cancer stem cell antigen EpCAM

(2015) Zhenling Deng et al.   BMC IMMUNOLOGY

Activated and expanded natural killer cells target osteosarcoma tumor initiating cells in an NKG2D–NKG2DL dependent manner

(2015) L. Fernández et al.   CANCER LETTERS

Engineering CAR-T cells: Design concepts

(2015) Shivani Srivastava et al.   TRENDS IN IMMUNOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma

(2014) Alessandra Soriani et al.   OncoImmunology

Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation

(2013) Wai-Hang Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse Tumor Vasculature Expresses NKG2D Ligands and Can Be Targeted by Chimeric NKG2D-Modified T Cells

(2013) T. Zhang et al.   JOURNAL OF IMMUNOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection

(2012) Manfred Lehner et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Treatment of multiple myeloma with adoptively transferred chimeric NKG2D receptor-expressing T cells

(2011) A Barber et al.   GENE THERAPY

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Isolation and characterization of cancer stem like cells in human glioblastoma cell lines

(2009) Lei Qiang et al.   CANCER LETTERS

Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment

(2009) A. Barber et al.   JOURNAL OF IMMUNOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87

(2008) Shi-cang Yu et al.   CANCER LETTERS

NKG2D ligands in tumor immunity

(2008) N Nausch et al.   ONCOGENE