AMP-activated protein kinase: the current landscape for drug development
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Title
AMP-activated protein kinase: the current landscape for drug development
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-03-14
DOI
10.1038/s41573-019-0019-2
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- AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
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- AMP-activated protein kinase (AMPK) 1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
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- AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
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- PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle
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- Activation of AMP-Activated Protein Kinase by 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside in the Muscle Microcirculation Increases Nitric Oxide Synthesis and Microvascular Perfusion
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- Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
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- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
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- Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo
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- Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo
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- Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity
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- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
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- Intravenous AICAR During Hyperinsulinemia Induces Systemic Hemodynamic Changes but Has No Local Metabolic Effect
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- Network organization of the human autophagy system
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- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
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- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
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- A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
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- Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status
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- Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging
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- AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development
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- AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance
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- Inflammation in Atherosclerosis
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- Ageing populations: the challenges ahead
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- AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
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- The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
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- AMPK and PPARδ Agonists Are Exercise Mimetics
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- Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance
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- Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue
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- Muscarinic Receptor Activation of AMP-activated Protein Kinase Inhibits Orexigenic Neuropeptide mRNA Expression
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- Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells
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- Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle
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- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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- Giant mitochondria do not fuse and exchange their contents with normal mitochondria
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