Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

(2019) Hisayuki Amano et al.   Cell Metabolism

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

(2019) Anna Walaszczyk et al.   AGING CELL

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

(2019) Claudia Chini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy

(2018) Nicola Manzella et al.   AGING CELL

Mitochondrial peptides modulate mitochondrial function during cellular senescence

(2018) Su-Jeong Kim et al.   Aging-US

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy

(2018) Salvatore Rizza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

(2018) Clara Correia-Melo et al.   AGING CELL

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

(2017) Yanlin Yin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

(2017) Robert A.H. van de Ven et al.   TRENDS IN MOLECULAR MEDICINE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Mechanisms of Selective Autophagy

(2016) Gabriele Zaffagnini et al.   JOURNAL OF MOLECULAR BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Depletion of mitochondria in mammalian cells through enforced mitophagy

(2016) Clara Correia-Melo et al.   Nature Protocols

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis

(2016) Wenduona Bao et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

(2015) Hagai Yanai et al.   Aging-US

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

(2015) Tanveer Ahmad et al.   FASEB JOURNAL

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5

(2014) Min Wan et al.   ATHEROSCLEROSIS

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

(2014) Piero Dalle Pezze et al.   PLoS Computational Biology

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

Cytosolic malate dehydrogenase regulates senescence in human fibroblasts

(2012) Seung-Min Lee et al.   BIOGERONTOLOGY

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Poly(ADP-Ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors

(2010) E. V. Efimova et al.   CANCER RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY