The bystander effect contributes to the accumulation of senescent cells in vivo

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function

(2017) Anne McArdle et al.   Essays in Biochemistry

Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts

(2017) Seul-Ki Park et al.   EXPERIMENTAL DERMATOLOGY

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey

(2017) A. Ishaq et al.   Journal of Nutrition Health & Aging

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

(2016) Lisa A. Lesniewski et al.   AGING CELL

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice

(2016) Ramy K.A. Sayed et al.   EXPERIMENTAL GERONTOLOGY

Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

(2016) Chunya Ni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Senescence in chronic liver disease: Is the future in aging?

(2016) Aloysious D. Aravinthan et al.   JOURNAL OF HEPATOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Adult-onset, short-term dietary restriction reduces cell senescence in mice

(2016) Chunfang Wang et al.   Aging-US

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Skeletal muscle as an immunogenic organ

(2008) S NIELSEN et al.   CURRENT OPINION IN PHARMACOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY