Article
Oncology
Feifei Guo, Yi Zhang, Ling Bai, Jiuwei Cui
Summary: Cancer stem cells (CSCs) are a small group of cancer cells with stem cell-like properties, which can be used for identifying malignant tumor phenotypes and patients with poor prognosis. Targeting CSCs has been shown to improve the effectiveness of cancer therapies. However, CSCs are resistant to conventional treatment methods such as radiotherapy and chemotherapy, hence the need for more effective anti-CSC therapies.
Article
Immunology
Eric Alves, Emily McLeish, Pilar Blancafort, Jerome D. D. Coudert, Silvana Gaudieri
Summary: The NKG2D receptor-ligand axis is essential for detecting cellular distress, damage, or transformation, with functional NKG2D ligands associated with tumor rejection and viral clearance. Many viruses and tumors evade NKG2D recognition, but CRISPR technology offers novel therapeutic opportunities to enhance and maximize NKG2D-mediated immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Katarina Pinjusic, Olivier Andreas Dubey, Olga Egorova, Sina Nassiri, Etienne Meylan, Julien Faget, Daniel Beat Constam
Summary: This study reveals that Activin-A secretion by melanoma cells inhibits adaptive antitumor immunity by indirectly inhibiting CD8(+) T cell infiltration, regardless of BRAF status. It is also found that Activin-A/INHBA expression is correlated with resistance to anti-PD1 therapy in melanoma patients and impairs response to combination anti-cytotoxic T-Lymphocyte associated protein 4/anti-PD1 treatment in preclinical models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Veterinary Sciences
William C. Kisseberth, Dean A. Lee
Summary: Osteosarcoma is a common primary bone tumor in both humans and dogs, and is highly metastatic. Immunotherapy, particularly targeting NK cells, may improve outcomes in treatment of this cancer. NK cells play a key role in controlling tumor progression and metastasis.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chunmei Yang, Cheng Qian, Tingting Zhang, Weiwei Zheng, Shan Zhang, Shijun Wang, Aiyun Wang, Yang Zhao, Yin Lu
Summary: Tanshinol can reverse the inhibitory effect of TGF-beta 1 on NK cell functions, promoting NK cells to carry out immune attacks on tumor cells.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Multidisciplinary Sciences
Rueyhung R. Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai
Summary: Gamma delta T cells are a subtype of T cells that can bridge the gap between the innate and adaptive immune system by attacking cancer cells in an MHC-unrestricted manner. Treatment of solid tumors with DNA methyltransferase inhibitors has been shown to enhance tumor cell susceptibility to gamma delta T cell killing through the upregulation of surface molecules and modulation of cytoskeleton arrangements. This combinatorial approach holds promise for lung cancer management by utilizing DNMTis and gamma delta T cell-based immunotherapy.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Pouria Momayyezi, Eleni Bilev, Hans-Gustaf Ljunggren, Quirin Hammer
Summary: This review examines immune evasion strategies employed by viruses, focusing on examples from human CMV and SARS-CoV-2. Three classes of viral evasion mechanisms are explored, including providing ligands for inhibitory receptor NKG2A, downregulating ligands for activating receptor NKG2D, and inducing immunosuppressive cytokine transforming growth factor (TGF)-β. The parallel comparison between viral and tumor immune evasion is discussed, with potential opportunities for overcoming evasion in cancer therapy. Insights gained from antiviral NK-cell responses may serve as valuable lessons for designing future cancer immunotherapies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Yuli Jian, Kangkang Yang, Xiaoxin Sun, Jun Zhao, Kai Huang, Abdullah Aldanakh, Zhongyang Xu, Haotian Wu, Qiwei Xu, Lin Zhang, Chunyan Xu, Deyong Yang, Shujing Wang
Summary: Renal cell carcinoma is a highly heterogeneous cancer group, with immune evasion being a hot topic in current research. Immunotherapy is considered the best treatment option for patients with metastatic or advanced renal cell carcinoma, and combination immunotherapy shows promising prospects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Halin Bareke, Adrian Ibanez-Navarro, Pilar Guerra-Garcia, Carlos Gonzalez Perez, Pedro Rubio-Aparicio, Diego Plaza Lopez de Sabando, Ana Sastre-Urgelles, Eduardo Jose Ortiz-Cruz, Antonio Perez-Martinez
Summary: Malignant bone tumors, such as Ewing sarcoma and osteosarcoma, are highly aggressive and tend to metastasize, mainly affecting adolescents during rapid growth spurts. Current therapies for pediatric patients with progressive malignant bone sarcomas, despite being aggressive, have poor survival rates and can have long-term effects on bone growth. In recent years, there has been a growing interest in utilizing the immune system, particularly natural killer (NK) cells, for the treatment of cancer. NK-cell immunotherapy has shown promising results in killing pediatric sarcoma cells and has advantages over T-cell adoptive therapy. This review discusses the potential of NK-cell immunotherapy as a new treatment approach for pediatric malignant bone tumors and explores the challenges and future directions in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Nohelly Derosiers, William Aguilar, David A. DeGaramo, Avery D. Posey
Summary: Despite the success in treating hematological malignancies, the effectiveness of chimeric antigen receptor T cell therapy against solid tumors is still limited due to the engagement of immune checkpoint molecules and glycoimmune interactions in the tumor microenvironment. This review discusses strategies to overcome the inhibitory PD-L1/PD-1 axis and highlights the importance of glycan-binding proteins in modulating T cell immunosuppression.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Ken Maes, Anna Mondino, Juan Jose Lasarte, Xabier Agirre, Karin Vanderkerken, Felipe Prosper, Karine Breckpot
Summary: Cancer cells can evade the immune system through epigenetic alterations, but epigenetic modulating agents have the potential to restore immunological fitness and overcome peripheral tolerance to transformed cells. By acting on both cancer cells and immune cells, EMAs represent interesting strategies for combinatorial therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Changhee Park, Kyeonghun Jeong, Joon-Hyeong Park, Sohee Jung, Jeong Mo Bae, Kwangsoo Kim, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Se-Hoon Lee, Ju-Seog Lee, Dong-Wan Kim, Gyeong Hoon Kang, Doo Hyun Chung, Dae Seog Heo
Summary: The study demonstrated a negative correlation between overall methylation aberrancy and tumor immunogenicity, indicating the importance of methylation aberrancy for tumors to evade immune surveillance. This highlights the need for further development of methylation biomarkers in cancer research.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Urology & Nephrology
Xiaoyang Wang, Robert Lopez, Rebecca A. Luchtel, Sassan Hafizi, Benjamin Gartrell, Niraj Shenoy
Summary: This article reviews the advancements in targeted therapies and immune checkpoint inhibitors in the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade, emphasizing the importance of understanding the mechanisms adopted by RCC cells to evade immune killing and exploring current clinical trials and future directions in the field.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On
Summary: Reovirus infection can downregulate NKG2D ligands on tumor cells, impairing the recognition and elimination of tumors by natural killer (NK) cells. This finding may lead to the development of new reovirus-based therapeutics to enhance the anti-tumor immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Hongyu Zhang, Zilong Liu, Haoyu Wen, Yifan Guo, Fengkai Xu, Qiaoliang Zhu, Wei Yuan, Rongkui Luo, Chunlai Lu, Ronghua Liu, Jie Gu, Di Ge
Summary: This study reveals the presence of a TAM subtype associated with immunotherapy response in non-small cell lung cancer (NSCLC), specifically, the TREM2 positive TAMs. NSCLC patients with high infiltration of TREM2(+) TAMs show advanced tumor progression and poor prognosis, as well as unique molecular characteristics. Low TREM2(+) TAMs predict higher response rates to PD-1-based immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Emilia Rutkowski, Stefan Leibelt, Christina Born, Miriam E. Friede, Stefan Bauer, Sandra Weil, Joachim Koch, Alexander Steinle
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Miriam E. Friede, Stefan Leibelt, Diana Dudziak, Alexander Steinle
JOURNAL OF IMMUNOLOGY
(2018)
Article
Oncology
Stefanie Maurer, Korbinian Nepomuk Kropp, Gerd Klein, Alexander Steinle, Sebastian P. Haen, Juliane S. Walz, Clemens Hinterleitner, Melanie Maerklin, Hans-Georg Kopp, Helmut Rainer Salih
Article
Oncology
Korbinian N. Kropp, Stefanie Maurer, Kathrin Rothfelder, Bastian J. Schmied, Kim L. Clar, Moritz Schmidt, Benedikt Strunz, Hans-Georg Kopp, Alexander Steinle, Frank Gruenebach, Susanne M. Rittig, Helmut R. Salih, Daniela Doerfel
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Immunology
Sebastian Neuss, Yvonne Bartel, Christina Born, Sandra Weil, Joachim Koch, Christian Behrends, Meike Hoffmeister, Alexander Steinle
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Tobias Zoeller, Mareike Wittenbrink, Meike Hoffmeister, Alexander Steinle
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Francisca F. Almeida, Sara Tognarelli, Antoine Marcais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zoeller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G. Chiocchetti, Sophie Ugolini, Marco J. Herold, Wei Shi, Joachim Koch, Alexander Steinle, Eric Vivier, Thierry Walzer, Gabrielle T. Belz, Evelyn Ullrich
Review
Pharmacology & Pharmacy
Mariya Lazarova, Alexander Steinle
EXPERT OPINION ON THERAPEUTIC TARGETS
(2019)
Article
Multidisciplinary Sciences
Anna M. Paczulla, Kathrin Rothfelder, Simon Raffel, Martina Konantz, Julia Steinbacher, Hui Wang, Claudia Tandler, Marcelle Mbarga, Thorsten Schaefer, Mattia Falcone, Eva Nievergall, Daniela Dorfel, Pauline Hanns, Jakob R. Passweg, Christoph Lutz, Juerg Schwaller, Robert Zeiser, Bruce R. Blazar, Michael A. Caligiuri, Stephan Dirnhofer, Pontus Lundberg, Lothar Kanz, Leticia Quintanilla-Martinez, Alexander Steinle, Andreas Trumpp, Helmut R. Salih, Claudia Lengerke
Article
Biotechnology & Applied Microbiology
Mariya Lazarova, Winfried S. Wels, Alexander Steinle
EXPERT OPINION ON BIOLOGICAL THERAPY
(2020)
Article
Immunology
Younghoon Kim, Christina Born, Mathieu Blery, Alexander Steinle
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Mariya Lazarova, Younghoon Kim, Alexander Steinle
Summary: The study examined the expression of ULBP4 in human peripheral blood mononuclear cells and monocytes, revealing that ULBP4 is not expressed by monocytes and likely not by other peripheral blood immune cells. This expression pattern is distinct from other human NKG2DL.
Article
Hematology
Berengere Salome, Alejandra Gomez-Cadena, Romain Loyon, Madeleine Suffiotti, Valentina Salvestrini, Tania Wyss, Giulia Vanoni, Dan Fu Ruan, Marianna Rossi, Alessandra Tozzo, Paolo Tentorio, Elena Bruni, Carsten Riether, Eva-Maria Jacobsen, Peter Jandus, Curdin Conrad, Manfred Hoenig, Ansgar Schulz, Katarzyna Michaud, Matteo Giovanni Della Porta, Silvia Salvatore, Ping-Chih Ho, David Gfeller, Adrian Ochsenbein, Domenico Mavilio, Antonio Curti, Emanuela Marcenaro, Alexander Steinle, Amir Horowitz, Pedro Romero, Sara Trabanelli, Camilla Jandus
Article
Oncology
Tobias Weiss, Hannah Schneider, Manuela Silginer, Alexander Steinle, Martin Pruschy, Bojan Polic, Michael Weller, Patrick Roth
CLINICAL CANCER RESEARCH
(2018)