Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review

SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKα signaling pathway

(2020) Jieyun Hong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Taurine protects against cardiac dysfunction induced by pressure overload through SIRT1–p53 activation

(2020) Jing Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bioactive peptides attenuate cardiac apoptosis in spontaneously hypertensive rat hearts through activation of autophagy and mitochondrial biogenesis pathway

(2020) Wan Teng Lin et al.   ENVIRONMENTAL TOXICOLOGY

Resveratrol promotes white adipocytes browning and improves metabolic disorders in Sirt1‐dependent manner in mice

(2020) Zilun Li et al.   FASEB JOURNAL

SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells

(2020) G Dönmez Yalçın et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice

(2020) Kei Ishizuka et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting

(2020) Enxiang Zhang et al.   JOURNAL OF LIPID RESEARCH

High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3

(2020) Rui Guo et al.   PHYTOMEDICINE

Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice

(2020) Jeonghyeon Kwon et al.   PLoS One

Role of Sirt3 in Differential Sex-Related Responses to a High-Fat Diet in Mice

(2020) Marija Pinterić et al.   Antioxidants

Vitamin K2 alleviates insulin resistance in skeletal muscle by improving mitochondrial function via SIRT1 signaling

(2020) xiangni su et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice

(2020) Daeun Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain

(2020) Taskeen Fathima Docrat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Undaria pinnatifida extract feeding increases exercise endurance and skeletal muscle mass by promoting oxidative muscle remodeling in mice

(2020) Jisong Ahn et al.   FASEB JOURNAL

Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression

(2020) Lei Liu et al.   JOURNAL OF DAIRY SCIENCE

Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways

(2020) Diego Luna-Vital et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

(2020) Daniel C. Levine et al.   MOLECULAR CELL

Effects of Sirt3‑autophagy and resveratrol activation on myocardial hypertrophy and energy metabolism

(2020) Hai‑Ning Wang et al.   Molecular Medicine Reports

Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense

(2020) Zheng Li et al.   PHYTOMEDICINE

Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα

(2020) Feng-Zhi Xin et al.   WORLD JOURNAL OF GASTROENTEROLOGY

4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage

(2020) Hye Joung Choi et al.   Scientific Reports

Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis

(2020) Youli Yao et al.   Frontiers in Pharmacology

Prdx6 Plays a Main Role in the Crosstalk between Aging and Metabolic Sarcopenia

(2020) Francesca Pacifici et al.   Antioxidants

Small molecule‐driven SIRT3‐autophagy mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes

(2020) Tian Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sirtuin 3‐mediated deacetylation of acyl‐ CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease

(2020) Ruimin Sun et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

(2020) João S. Teodoro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depot-specific regulation of NAD+/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction

(2020) Xiaojing Wei et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation

(2020) Ning Jiang et al.   LIFE SCIENCES

Administration of kynurenic acid reduces hyperlipidemia-induced inflammation and insulin resistance in skeletal muscle and adipocytes

(2020) Tae Woo Jung et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Resveratrol Alleviates Endoplasmic Reticulum Stress–Associated Hepatic Steatosis and Injury in Mice Challenged with Tunicamycin

(2020) Yanan Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Influence of the maternal high-intensity-interval-training on the cardiac Sirt6 and lipid profile of the adult male offspring in rats

(2020) Reihaneh Mohammadkhani et al.   PLoS One

Mechanism of Action of Ketogenic Diet Treatment: Impact of Decanoic Acid and Beta—Hydroxybutyrate on Sirtuins and Energy Metabolism in Hippocampal Murine Neurons

(2020) Partha Dabke et al.   Nutrients

ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis

(2020) Lihua Hao et al.   JCI Insight

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

(2020) Chuanhai Zhang et al.   iScience

miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload

(2020) Li Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats

(2020) yong zhang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2

(2020) Emma Barroso et al.   Cell Communication and Signaling

Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

(2020) Leonie Drews et al.   Disease Models & Mechanisms

Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways

(2020) Mohamad Hafizi Abu Bakar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism

(2020) Nozomi Furukawa et al.   HEART AND VESSELS

lncRNA TUG1 promotes the brown remodeling of white adipose tissue by regulating miR‑204‑targeted SIRT1 in diabetic mice

(2020) Ying Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding

(2020) Long T. Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

(2020) Yann Deleye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improvement of cardiac function in rats with myocardial infarction by low- to moderate-intensity endurance exercise is associated with normalization of Klotho and SIRT1

(2020) Hamid Najafipour et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids

(2020) Hongbo Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice

(2020) Ying Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice

(2020) Jingjing Yuan et al.   PHYTOMEDICINE

Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

(2020) Fan Yang et al.   Drug Design Development and Therapy

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

(2020) Carmen Escalona-Garrido et al.   Molecular Metabolism

Hypoxia exacerbates cardiomyocyte injury via upregulation of Wnt3a and inhibition of Sirt3

(2020) Yanming Li et al.   CYTOKINE

MiR-33a inhibits the adipogenic differentiation of ovine adipose–derived stromal vascular fraction cells by targeting SIRT6

(2020) Q. Wang et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo

(2019) Tejas Desai et al.   Nutrition & Diabetes

Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice

(2019) Zhimeng Zhao et al.   NUTRITIONAL NEUROSCIENCE

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

(2019) Nunzia D’Onofrio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress

(2019) Guiping Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway

(2019) Jun Huang et al.   CNS Neuroscience & Therapeutics

Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells

(2019) Mei-Chen Lo et al.   ARCHIVES OF PHARMACAL RESEARCH

Molecular and functional characterization of sirt4 and sirt6 in Megalobrama amblycephala under high glucose metabolism

(2019) Shan-Ting Lin et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue

(2019) Lin Shuai et al.   DIABETES

Fatty acid type–specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

(2019) Andreas Mæchel Fritzen et al.   FASEB JOURNAL

Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells

(2019) Garima Sharma et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

(2019) GuoXiao Wang et al.   MOLECULAR CELL

Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons

(2019) Manuel Flores-León et al.   NEUROCHEMICAL RESEARCH

Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice

(2019) Hung-Wen Liu et al.   Nutrition & Metabolism

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

(2019) Yong Liu et al.   Nature Communications

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1

(2019) Rajaa Sebaa et al.   Molecular Metabolism

Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release

(2019) Fang Li et al.   CELL CYCLE

SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity

(2019) Tian Zhang et al.   CELL DEATH AND DIFFERENTIATION

Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway

(2019) Chian-Jiun Liou et al.   FASEB JOURNAL

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

(2019) Abhinav Kanwal et al.   FASEB JOURNAL

Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease

(2019) Liang Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Moderate Protein Restriction Protects Against Focal Cerebral Ischemia in Mice by Mechanisms Involving Anti-inflammatory and Anti-oxidant Responses

(2019) Tayana Silva de Carvalho et al.   MOLECULAR NEUROBIOLOGY

Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity

(2019) Sebastio Perrini et al.   INTERNATIONAL JOURNAL OF OBESITY

Platycodon grandiflorus Root Ethanol Extract Induces Lipid Excretion, Lipolysis, and Thermogenesis in Diet-Induced Obese Mice

(2019) Ye Jin Kim et al.   JOURNAL OF MEDICINAL FOOD

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

(2019) Su Myung Jung et al.   MOLECULAR CELL

SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation

(2019) Shang Ying Wu et al.   STEM CELLS

Liraglutide improves insulin sensitivity in high fat diet induced diabetic mice through multiple pathways

(2019) Joseph Yi Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apple Polyphenol Extract Alleviates High-Fat-Diet-Induced Hepatic Steatosis in Male C57BL/6 Mice by Targeting LKB1/AMPK Pathway

(2019) Deming Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

γ-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells

(2019) Liang Gu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol and Oxyresveratrol Activate Thermogenesis via Different Transcriptional Coactivators in High-Fat Diet-Induced Obese Mice

(2019) Min-Hsiung Pan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach

(2019) Alanna Fernandes Paraíso et al.   LIFE SCIENCES

Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts

(2019) Hiroaki Sunaga et al.   Scientific Reports

Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

(2019) Kristoffer Svensson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction

(2019) Ashley S. Williams et al.   Cell Metabolism

Antiobesity effects of coumestrol through expansion and activation of brown adipose tissue metabolism

(2019) Sang-Nam Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

(2019) Xue-Yang Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

(2019) Shoshana Naiman et al.   Cell Reports

NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism

(2018) Lane C Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amelioration of myocardial ischemia-reperfusion injury by SIRT4 involves mitochondrial protection and reduced apoptosis

(2018) Guangwei Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice

(2018) Min Jo Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High expression of CPT1b in skeletal muscle in metabolically healthy older subjects

(2018) C. Bétry et al.   DIABETES & METABOLISM

SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

(2018) Kunhua Qin et al.   DIABETOLOGIA

SIRT5 and post-translational protein modifications: A potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism

(2018) Rongjun Zou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells

(2018) Yu-Ting Wu et al.   FREE RADICAL RESEARCH

Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice

(2018) Yuanyuan Zheng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression

(2018) Fariba Assadi-Porter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis

(2018) Mohsen Sarikhani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart

(2018) Danish Khan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose

(2018) Anjum Dihingia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra

(2018) Ana Muñoz et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF‑κB pathway in mouse kupffer cells

(2018) Bailin Niu et al.   Molecular Medicine Reports

A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

(2018) Md Mahdi Hasan-Olive et al.   NEUROCHEMICAL RESEARCH

Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis

(2018) Nicolas Burg et al.   NEUROSCIENCE RESEARCH

SIRT5 regulates pancreatic β‑cell proliferation and insulin secretion in type 2 diabetes

(2018) Yongmei Ma et al.   Experimental and Therapeutic Medicine

Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein

(2018) Hitoshi Watanabe et al.   Nature Communications

Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain

(2018) Kevin B. Koronowski et al.   Frontiers in Neuroscience

Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats

(2018) Jingwei Zheng et al.   Frontiers in Neuroscience

Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

(2018) Jian Li et al.   Frontiers in Pharmacology

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

(2018) Zhuoran Wang et al.   Aging-US

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

(2018) Maayan Waldman et al.   Cardiovascular Diabetology

Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway

(2018) Man Xu et al.   CARDIOVASCULAR RESEARCH

CD38 Deficiency Protects Heart from High Fat Diet-Induced Oxidative Stress Via Activating Sirt3/FOXO3 Pathway

(2018) Ling-Fang Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice

(2018) Chian-Jiun Liou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction

(2018) Yue Wang et al.   EXPERIMENTAL CELL RESEARCH

Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression

(2018) Wei Yu et al.   Molecular Medicine Reports

Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1

(2018) Myeong-Gang Heo et al.   Food & Function

Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice

(2018) Allah Nawaz et al.   Scientific Reports

Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls

(2018) Erika Koltai et al.   Redox Biology

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice

(2018) Yipeng Du et al.   EBioMedicine

Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism

(2018) Junxiang Yin et al.   Aging-US

Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis

(2018) Wei‐Wei Yan et al.   EMBO REPORTS

PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis

(2018) Maayan Waldman et al.   EXPERIMENTAL CELL RESEARCH

SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high‐fat feeding

(2018) Long T. Nguyen et al.   JOURNAL OF PHYSIOLOGY-LONDON

A SIRT1 agonist reduces cognitive decline in type 2 diabetic rats through antioxidative and anti‑inflammatory mechanisms

(2018) Fei Wang et al.   Molecular Medicine Reports

SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis

(2018) Mengting Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals

(2018) Marcos C. Carreira et al.   Oxidative Medicine and Cellular Longevity

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

(2018) Louise Lantier et al.   PLoS One

Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue

(2018) Seun Akindehin et al.   Nutrients

SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain

(2018) Alpna Tyagi et al.   Scientific Reports

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM

(2018) Pankaj Bagul et al.   Cells

AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway

(2017) Yili Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aerobic training but no resistance training increases SIRT3 in skeletal muscle of sedentary obese male adolescents

(2017) Katya Vargas-Ortiz et al.   European Journal of Sport Science

Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor

(2017) Sun-O Ka et al.   FASEB JOURNAL

Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction

(2017) Masaki Kobayashi et al.   FEBS LETTERS

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

(2017) Vera Lemos et al.   HUMAN MOLECULAR GENETICS

Emerging roles of SIRT1 in fatty liver diseases

(2017) Ren-Bo Ding et al.   International Journal of Biological Sciences

Dysregulation of mitochondrial function and biogenesis modulators in adipose tissue of obese children

(2017) R Zamora-Mendoza et al.   INTERNATIONAL JOURNAL OF OBESITY

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

(2017) Kathleen A. Hershberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure

(2017) Rongli Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

(2017) Mingming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Fucoidan ameliorates pancreatic β-cell death and impaired insulin synthesis in streptozotocin-treated β cells and mice via a Sirt-1-dependent manner

(2017) Wen-Chun Yu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by Sirt1

(2017) Shuanshuan Xu et al.   PLoS One

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

(2017) Jian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance

(2017) Kevin B. Koronowski et al.   STROKE

CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis

(2017) Min Jun Jang et al.   Cell Death & Disease

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

(2017) Jingxin Liu et al.   Cell Death & Disease

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy

(2017) Sadhana A. Samant et al.   Scientific Reports

Characterization of the direct targets of FOXO transcription factors throughout evolution

(2016) Ashley E. Webb et al.   AGING CELL

Inhibition of SIRT2 suppresses hepatic fibrosis

(2016) Maribel Arteaga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms

(2016) Xiao-Xiao Wang et al.   BASIC RESEARCH IN CARDIOLOGY

SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells

(2016) Amita Arora et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation

(2016) Atsushi Yamashita et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42and Phospho-Tau May Abet Alzheimer Development

(2016) Mini Sajan et al.   DIABETES

Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice

(2016) Tizhong Shan et al.   DIABETOLOGIA

Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity

(2016) Yu-Xuan Luo et al.   EUROPEAN HEART JOURNAL

Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1α Expression Levels in Rats of Different Age

(2016) Chi-Chang Huang et al.   International Journal of Medical Sciences

SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status

(2016) A Kurylowicz et al.   INTERNATIONAL JOURNAL OF OBESITY

Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue

(2016) Elisabeth Rappou et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Obesity Is Associated With Low NAD+/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

(2016) Sakari Jukarainen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata)

(2016) Paula Simó-Mirabet et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

(2016) Mark E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice

(2016) Zhenjiang Liu et al.   JOURNAL OF LIPID RESEARCH

Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1

(2016) F. D. Heyward et al.   JOURNAL OF NEUROSCIENCE

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

(2016) Asael Roichman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction

(2016) Hao-Hao Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke

(2016) Xiao Qiang Xie et al.   MOLECULAR NEUROBIOLOGY

Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons

(2016) Johanna Mäkelä et al.   NEUROPHARMACOLOGY

Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice

(2016) Fen Xu et al.   Obesity

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy

(2016) Jing Lu et al.   Translational Research

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

(2016) Khanh V. Doan et al.   Nature Communications

SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro

(2016) Yuanfei Zhou et al.   Oncotarget

Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5

(2016) Kahlilia C. Morris-Blanco et al.   Scientific Reports

Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis

(2016) Jung Hwan Yu et al.   Scientific Reports

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon

(2016) Lulu Li et al.   Scientific Reports

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage

(2016) Jiaxiang Shao et al.   Protein & Cell

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Effect of feeding regimens on circadian rhythms: Implications for agingand longevity

(2016) Oren Froy et al.   Aging-US

Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat

(2016) Mahua Choudhury et al.   Aging-US

SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

(2016) Linh Ho et al.   Aging-US

Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

(2016) Mi-Young Song et al.   Scientific Reports

SIRT3 deficiency impairs mitochondrial and contractile function in the heart

(2015) Christoph Koentges et al.   BASIC RESEARCH IN CARDIOLOGY

Activation of AMP-activated protein kinase induce expression of FoxO1, FoxO3a, and myostatin after exercise-induced muscle damage

(2015) Kihyuk Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood–brain barrier in mice

(2015) Hai-Ya Yu et al.   BRAIN INJURY

Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat

(2015) Mingzi Ran et al.   BRAIN RESEARCH

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice

(2015) Lina Ma et al.   BRAIN RESEARCH BULLETIN

SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching

(2015) Kristin E. Dittenhafer-Reed et al.   Cell Metabolism

Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling PathwayCLINICAL PERSPECTIVE

(2015) Satoshi Araki et al.   CIRCULATION

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

(2015) Louise Lantier et al.   DIABETES

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes

(2015) Richard E. Gilbert et al.   DIABETOLOGIA

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

(2015) Xiwen Xiong et al.   DIABETOLOGIA

Central Sirt1 Regulates Body Weight and Energy Expenditure Along With the POMC-Derived Peptide α-MSH and the Processing Enzyme CPE Production in Diet-Induced Obese Male Rats

(2015) Nicole E. Cyr et al.   ENDOCRINOLOGY

SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy

(2015) Qiong Yuan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells

(2015) Hao-Hao Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats

(2015) Agata Wronska et al.   GERONTOLOGY

Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats

(2015) V Ramachandran et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism

(2015) Rong Guo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

(2015) S Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss

(2015) Heng Zeng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Leptin Effect on Acetylation and Phosphorylation of Pgc1α in Muscle Cells Associated With Ampk and Akt Activation in High-Glucose Medium

(2015) Francisco García-Carrizo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirtuin 3 Mediates Neuroprotection of Ketones against Ischemic Stroke

(2015) Junxiang Yin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sirtuin function in aging heart and vessels

(2015) Chiara Cencioni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glucose regulates amyloid β production via AMPK

(2015) Ting-Ting Yang et al.   JOURNAL OF NEURAL TRANSMISSION

Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism

(2015) Benjamin D. Rowlands et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

(2015) Eduardo García-Fuentes et al.   Journal of Translational Medicine

Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1

(2015) Mark F. McCarty et al.   MEDICAL HYPOTHESES

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain

(2015) Ai-Ling Lin et al.   NEUROBIOLOGY OF AGING

SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways

(2015) Q. Wang et al.   NEUROSCIENCE

Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia

(2015) P. Rangarajan et al.   NEUROSCIENCE

Aerobic Training Increases Expression Levels of SIRT3 and PGC-1α in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake

(2015) Katya Vargas-Ortiz et al.   PEDIATRIC EXERCISE SCIENCE

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

(2015) Andreia V. Pinho et al.   PLoS One

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

(2015) Michele Cioffi et al.   Cell Reports

Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice

(2015) Janet Guo et al.   Frontiers in Aging Neuroscience

Inborn Errors of Metabolism

(2015) Hilary J. Vernon   JAMA Pediatrics

Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation

(2015) L. Yu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

(2015) Marie Boutant et al.   Molecular Metabolism

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

(2015) Rafael Mayoral et al.   Molecular Metabolism

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

(2015) Jason G. Anderson et al.   Molecular Metabolism

Overexpression of SIRT1 in Rat Skeletal Muscle Does Not Alter Glucose Induced Insulin Resistance

(2015) Amanda E. Brandon et al.   PLoS One

SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

(2015) Yuxun Zhang et al.   PLoS One

SIRT3 Overexpression Attenuates Palmitate-Induced Pancreatic β-Cell Dysfunction

(2015) Min Kim et al.   PLoS One

Sirt2 induces C2C12 myoblasts proliferation by activation of the ERK1/2 pathway

(2014) Guofang Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression

(2014) Amanda T. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

(2014) Fengying Yang et al.   BEHAVIOURAL BRAIN RESEARCH

GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity

(2014) Gérald J. Prud’homme et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells

(2014) Amita Arora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress

(2014) Jun-gang Zhang et al.   CANCER SCIENCE

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

(2014) Tatsuya Yoshizawa et al.   Cell Metabolism

Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues

(2014) Cheng Xu et al.   DIABETES

Preserved Energy Balance in Mice Lacking FoxO1 in Neurons of Nkx2.1 Lineage Reveals Functional Heterogeneity of FoxO1 Signaling Within the Hypothalamus

(2014) Garrett Heinrich et al.   DIABETES

Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1  Pathway

(2014) K. Bantubungi et al.   DIABETES

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

(2014) João Marcus Oliveira Andrade et al.   EUROPEAN JOURNAL OF NUTRITION

The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise

(2014) Katarina Marcinko et al.   EXPERIMENTAL PHYSIOLOGY

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism

(2014) Marcin Buler et al.   FASEB JOURNAL

Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure

(2014) Kian Peng Goh et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Short-term calorie restriction activates SIRT1–4 and -7 in cardiomyocytes in vivo and in vitro

(2014) WEI YU et al.   Molecular Medicine Reports

Caloric restriction mimetics: towards a molecular definition

(2014) Frank Madeo et al.   NATURE REVIEWS DRUG DISCOVERY

Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response

(2014) Alessio Cardinale et al.   NEUROCHEMICAL RESEARCH

Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice

(2014) Vina Yanti Susanti et al.   Obesity

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

(2014) S. O'Neill et al.   Obesity Reviews

Regulation of Skeletal Muscle Oxidative Capacity and Muscle Mass by SIRT3

(2014) Ligen Lin et al.   PLoS One

High altitude exposure alters gene expression levels of DNA repair enzymes, and modulates fatty acid metabolism by SIRT4 induction in human skeletal muscle

(2014) Zoltan Acs et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

(2014) Nobuyuki Toshikuni   WORLD JOURNAL OF GASTROENTEROLOGY

Ketogenic Diet for Obesity: Friend or Foe?

(2014) Antonio Paoli   International Journal of Environmental Research and Public Health

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

(2014) Anil M Narasimha et al.   eLife

A metabolic link to skeletal muscle wasting and regeneration

(2014) René Koopman et al.   Frontiers in Physiology

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: An immunohistochemical study

(2013) Gaia Favero et al.   ACTA HISTOCHEMICA

Protective effect of nicotinamide on high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells is attributed to its inhibitory activity to sirtuins

(2013) Soo-Jin Lee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

(2013) Ok-Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases

(2013) Janet D. Sparks et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2 Cardiomyoblast Cells

(2013) Ban Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes

(2013) Young Sook Song et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

(2013) Tsutomu Sasaki et al.   DIABETOLOGIA

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

(2013) A. T. White et al.   DIABETOLOGIA

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients

(2013) P. W. Caton et al.   DIABETOLOGIA

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome

(2013) Annabelle Z. Caron et al.   FASEB JOURNAL

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

(2013) Shashi Kiran et al.   FEBS Journal

SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation

(2013) Rui-Hong Wang et al.   International Journal of Biological Sciences

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucose Regulates Hypothalamic Long-chain Fatty Acid Metabolism via AMP-activated Kinase (AMPK) in Neurons and Astrocytes

(2013) Bouchra Taïb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues

(2013) Min Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

(2013) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression

(2013) Rongya Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity

(2013) Alexander R. Moschen et al.   JOURNAL OF HEPATOLOGY

Insulin Inhibits Lipolysis in Adipocytes via the Evolutionarily Conserved mTORC1-Egr1-ATGL-Mediated Pathway

(2013) P. Chakrabarti et al.   MOLECULAR AND CELLULAR BIOLOGY

The Winged Helix Transcription Factor Foxa3 Regulates Adipocyte Differentiation and Depot-Selective Fat Tissue Expansion

(2013) Lingyan Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation

(2013) Gaëlle Laurent et al.   MOLECULAR AND CELLULAR BIOLOGY

The Yeast AMPK Homolog SNF1 Regulates Acetyl Coenzyme A Homeostasis and Histone Acetylation

(2013) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats

(2013) Yong-Ru Chen et al.   MOLECULAR BIOLOGY REPORTS

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Diet composition modulate expression of sirtuins and Renin-Angiotensin system components in adipose tissue

(2013) Lucinéia de Pinho et al.   Obesity

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer’s Pathology

(2013) Milene L. Brownlow et al.   PLoS One

A Role for SIRT6 in Secretion

(2013) J. F. Foley   Science Signaling

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Metabolic Characterization of a Sirt5 deficient mouse model

(2013) Jiujiu Yu et al.   Scientific Reports

PPAR-α as a Key Nutritional and Environmental Sensor for Metabolic Adaptation

(2013) Alejandra V. Contreras et al.   Advances in Nutrition

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions

(2013) Christian Linke et al.   Frontiers in Physiology

Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4

(2012) Yong-Chul Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes

(2012) Lucía Serrano-Marco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction

(2012) Ling Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin 6 protects cardiomyocytes from hypertrophyin vitrovia inhibition of NF-κB-dependent transcriptional activity

(2012) Shan-Shan Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

(2012) Asuka Shiota et al.   Cardiovascular Diabetology

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

(2012) Nuno Raimundo et al.   CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

FOXOs and Sirtuins in Vascular Growth, Maintenance, and Aging

(2012) Mark F. Oellerich et al.   CIRCULATION RESEARCH

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Metabolic Syndrome and Risk of Cancer: A systematic review and meta-analysis

(2012) K. Esposito et al.   DIABETES CARE

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Thiazolidinedione safety

(2012) Jacqueline Kung et al.   Expert Opinion On Drug Safety

Timed high-fat diet resets circadian metabolism and prevents obesity

(2012) Hadas Sherman et al.   FASEB JOURNAL

FoxO6 regulates memory consolidation and synaptic function

(2012) D. A. M. Salih et al.   GENES & DEVELOPMENT

Dietary obesity-associated Hif1  activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

(2012) J. Krishnan et al.   GENES & DEVELOPMENT

Analysis of the role of hepatic PPARγ expression during mouse liver regeneration

(2012) Vered Gazit et al.   HEPATOLOGY

Effect of Dietary Macronutrient Composition on AMPK and SIRT1 Expression and Activity in Human Skeletal Muscle

(2012) B. Draznin et al.   HORMONE AND METABOLIC RESEARCH

Cdk5 Levels Oscillate during the Neuronal Cell Cycle

(2012) Jie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO1 in the ventromedial hypothalamus regulates energy balance

(2012) Ki Woo Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

(2012) Pierre-Gilles Blanchard et al.   JOURNAL OF LIPID RESEARCH

The role of AMP-activated protein kinase in regulating white adipose tissue metabolism

(2012) R.B. Ceddia   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

Parallel Down-Regulation of FOXO1, PPAR? and Adiponectin mRNA Expression in Visceral Adipose Tissue of Class III Obese Individuals

(2012) Thais Ortiz Hammes et al.   Obesity Facts

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo

(2012) Anna Bobrowska et al.   PLoS One

Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption

(2012) O. M. Buxton et al.   Science Translational Medicine

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

(2012) Pablo J. Fernandez-Marcos et al.   Scientific Reports

Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells

(2012) Pooneh Memar Ardestani et al.   Nucleus

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

(2011) David M. Taylor et al.   ACS Chemical Biology

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Activated AMPK inhibits PPAR-α and PPAR-γ transcriptional activity in hepatoma cells

(2011) Margaret S. Sozio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

(2011) Marta A. Paiva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis

(2011) Brendon J. Gurd   Applied Physiology Nutrition and Metabolism

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins

(2011) Matteo Barberis et al.   BIOTECHNOLOGY ADVANCES

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic  -Cell Mass Expansion

(2011) P.-O. Bastien-Dionne et al.   DIABETES

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice

(2011) Xiao Yu et al.   EMBO JOURNAL

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

(2011) Sharon S. McDaniel et al.   EPILEPSIA

Central FoxO3a and FoxO6 Expression is Down­regulated in Obesity Induced Diabetes but not in Aging

(2011) J. Zemva et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

(2011) Sarah A. Reed et al.   FASEB JOURNAL

Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1α in mice in vivo

(2011) Lan Xiang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Concept of Metabolic Syndrome: Contribution of Visceral Fat Accumulation and Its Molecular Mechanism

(2011) Yuji Matsuzawa et al.   Journal of Atherosclerosis and Thrombosis

Identification of Macrodomain Proteins as NovelO-Acetyl-ADP-ribose Deacetylases

(2011) Dawei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

(2011) Albert Giralt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide

(2011) Katherine J. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation

(2011) William C. Hallows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction

(2011) Yi-Qun Geng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

(2011) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase–independent manner

(2011) Brendon J. Gurd et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

(2011) Max R. Banko et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

E2F transcription factor-1 regulates oxidative metabolism

(2011) Emilie Blanchet et al.   NATURE CELL BIOLOGY

Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings

(2011) John F Trepanowski et al.   Nutrition Journal

Evolution of networks and sequences in eukaryotic cell cycle control

(2011) F. R. Cross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function

(2011) Dongmei Wu et al.   PLoS One

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

(2011) B. Beirowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

(2010) Kristy Iskandar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration

(2010) Weiping Qin et al.   Annals of the New York Academy of Sciences

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

High-intensity interval training increases SIRT1 activity in human skeletal muscle

(2010) Brendon J. Gurd et al.   Applied Physiology Nutrition and Metabolism

Short-term fasting induces profound neuronal autophagy

(2010) Mehrdad Alirezaei et al.   Autophagy

Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver

(2010) Joo-Man Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Mitochondrial SIRT3 and heart disease

(2010) V. B. Pillai et al.   CARDIOVASCULAR RESEARCH

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

(2010) Giorgio Ramadori et al.   Cell Metabolism

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

Roles of FoxO1 and Sirt1 in the central regulation of food intake

(2010) Tsutomu Sasaki et al.   ENDOCRINE JOURNAL

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

(2010) Rocio Vila-Bedmar et al.   ENDOCRINOLOGY

Cyclin G2 Regulates Adipogenesis through PPARγ Coactivation

(2010) Victor Aguilar et al.   ENDOCRINOLOGY

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells

(2010) Nargis Nasrin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

(2010) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus

(2010) A. Satoh et al.   JOURNAL OF NEUROSCIENCE

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

(2010) R. K. Minor et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Roles of Cyclin A2, B1, and B2 in Early and Late Mitotic Events

(2010) Delquin Gong et al.   MOLECULAR BIOLOGY OF THE CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Resveratrol Upregulated SIRT1, FOXO1, and Adiponectin and Downregulated PPARγ1–3 mRNA Expression in Human Visceral Adipocytes

(2010) Cíntia dos Santos Costa et al.   OBESITY SURGERY

Oxidative Stress as a Mediator of Cardiovascular Disease

(2010) Maqsood M. Elahi et al.   Oxidative Medicine and Cellular Longevity

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

(2010) B. Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats

(2009) Xiangqun Deng et al.   ACTA DIABETOLOGICA

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

(2009) Kathryn Moynihan Ramsey et al.   AGING CELL

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

AMPK inhibits myoblast differentiation through a PGC-1α-dependent mechanism

(2009) David L. Williamson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

(2009) Hiroshi Nakanishi et al.   BEHAVIOURAL BRAIN RESEARCH

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

(2009) Eric E. Zhang et al.   CELL

Chronological expression of Wnt target genes Ccnd1, Myc, Cdkn1a, Tfrc, Plf1 and Ramp3

(2009) Sonja Röhrs et al.   CELL BIOLOGY INTERNATIONAL

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

(2009) Joon-Young Park et al.   CIRCULATION RESEARCH

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease

(2009) Stergios A. Polyzos et al.   DIABETES OBESITY & METABOLISM

Metabolic diseases and associated complications: sex and gender matter!

(2009) A. Kautzky-Willer et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Important role for AMPKα1 in limiting skeletal muscle cell hypertrophy

(2009) Rémi Mounier et al.   FASEB JOURNAL

Cytokine Regulation of AMPK signalling

(2009) Gregory et al.   Frontiers in Bioscience-Landmark

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

(2009) D. E. Cohen et al.   GENES & DEVELOPMENT

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats

(2009) Eduardo R. Ropelle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

(2009) Erika Koltai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

(2009) Sebastian Greiss et al.   MOLECULES AND CELLS

The CDK4–pRB–E2F1 pathway controls insulin secretion

(2009) Jean-Sébastien Annicotte et al.   NATURE CELL BIOLOGY

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Degradation of cyclin A is regulated by acetylation

(2009) F Mateo et al.   ONCOGENE

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

(2009) A Satyanarayana et al.   ONCOGENE

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

(2009) Kay-Dietrich Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Cyclin A-Cdk1 regulates the origin firing program in mammalian cells

(2009) Y. Katsuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

The conservation and evolutionary modularity of metabolism

(2009) José M Peregrín-Alvarez et al.   GENOME BIOLOGY

Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue

(2008) Jun Yin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Where in the cell is SIRT3? – functional localization of an NAD+-dependent protein deacetylase

(2008) William C. Hallows et al.   BIOCHEMICAL JOURNAL

The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?

(2008) Reinhard Stöger   BIOESSAYS

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Cdk-counteracting phosphatases unlock mitotic exit

(2008) Ethel Queralt et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

Insulin Resistance and Hyperinsulinemia: You can't have one without the other

(2008) S. H. Kim et al.   DIABETES CARE

The Adipocyte as an Endocrine Cell

(2008) Nils Halberg et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Sirt1 increases skeletal muscle precursor cell proliferation

(2008) Christopher R. Rathbone et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Regulation of SIRT6 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

(2008) Ruwin Pandithage et al.   JOURNAL OF CELL BIOLOGY

c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27Kip1 cyclin dependent kinase inhibitor

(2008) Vidyalakshmi Chandramohan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Peroxisome proliferator-activated receptor-α modulates insulin gene transcription factors and inflammation in adipose tissues in mice

(2008) Akadiri Yessoufou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activation of FoxM1 during G2 Requires Cyclin A/Cdk-Dependent Relief of Autorepression by the FoxM1 N-Terminal Domain

(2008) J. Laoukili et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPARγ

(2008) Fei Wang et al.   MOLECULAR BIOLOGY OF THE CELL

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events

(2008) L De Boer et al.   ONCOGENE

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle

(2008) Ayesha Saleem et al.   PHYSIOLOGICAL GENOMICS

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of CDK2 substrates in human cell lysates

(2008) Yong Chi et al.   GENOME BIOLOGY

Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

(2007) Yasuhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes

(2007) Linglin Xie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Downregulation of plasma insulin levels and hepatic PPARγ expression during the first week of caloric restriction in mice

(2007) Jacob D. Mulligan et al.   EXPERIMENTAL GERONTOLOGY

SIRT2, tubulin deacetylation, and oligodendroglia differentiation

(2007) Bor Luen Tang et al.   CELL MOTILITY AND THE CYTOSKELETON