A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function

(2017) Yong Ding et al.   International Journal of Biological Sciences

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

(2017) Jingxin Liu et al.   Cell Death & Disease

Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?

(2017) Marwa Elamin et al.   Frontiers in Molecular Neuroscience

Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters

(2017) Linda S. Forero-Quintero et al.   Scientific Reports

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

(2016) Krisztina Marosi et al.   JOURNAL OF NEUROCHEMISTRY

Uncoupling protein 2 protects mice from aging

(2016) Misa Hirose et al.   MITOCHONDRION

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

(2016) Knut H. Lauritzen et al.   NEUROBIOLOGY OF AGING

Sirtuin 3 Mediates Neuroprotection of Ketones against Ischemic Stroke

(2015) Junxiang Yin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial UCP2 in the central regulation of metabolism

(2014) Chitoku Toda et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Worldwide Dietary Therapies for Adults With Epilepsy and Other Disorders

(2013) Mackenzie C. Cervenka et al.   JOURNAL OF CHILD NEUROLOGY

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

(2013) Julia Brenmoehl et al.   MITOCHONDRION

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice

(2013) David N. Ruskin et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice

(2012) Shireesh Srivastava et al.   IUBMB LIFE

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dietary therapies for epilepsy: Future research

(2011) Sudha K. Kessler et al.   EPILEPSY & BEHAVIOR

Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond

(2011) Knut H. Lauritzen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease

(2011) David N. Ruskin et al.   PHYSIOLOGY & BEHAVIOR

Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

(2011) Qilong Wang et al.   PLoS One

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

(2010) François R. Jornayvaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative Stress and Energy Crises in Neuronal Dysfunction

(2010) David G. Nicholls   Annals of the New York Academy of Sciences

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

Ketogenic diet slows down mitochondrial myopathy progression in mice

(2010) Sofia Ahola-Erkkilä et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior

(2010) K. H. Lauritzen et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirtuins regulate key aspects of lipid metabolism

(2009) David J. Lomb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mitochondrial dynamics and neurodegeneration

(2009) Bingwei Lu   Current Neurology and Neuroscience Reports

The ketogenic diet improves recently worsened focal epilepsy

(2009) NATHALIE VILLENEUVE et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Ketogenic Diets: An Update for Child Neurologists

(2009) Eric H. Kossoff et al.   JOURNAL OF CHILD NEUROLOGY

Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet

(2008) Kristopher Bough   EPILEPSIA

PGC-1α Integrates Insulin Signaling, Mitochondrial Regulation, and Bioenergetic Function in Skeletal Muscle

(2008) Ines Pagel-Langenickel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunogold quantification of amino acids and proteins in complex subcellular compartments

(2008) Linda H Bergersen et al.   Nature Protocols

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA