Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity

(2013) Debapriya Dutta et al.   Autophagy

Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage

(2013) Mirko Völkers et al.   CIRCULATION

Role of microangiopathy in diabetic cardiomyopathy

(2013) Adriana Adameova et al.   HEART FAILURE REVIEWS

Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy

(2013) K. Maiellaro-Rafferty et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice

(2013) Andrea Stöhr et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

(2013) M. A. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetic cardiomyopathy: Myth or reality?

(2012) Laura Ernande et al.   Archives of Cardiovascular Diseases

Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts

(2012) Saisudha Koka et al.   BASIC RESEARCH IN CARDIOLOGY

Carbonic anhydrase II promotes cardiomyocyte hypertrophy

(2012) Brittany F. Brown et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

(2012) Zhao Chong et al.   Cardiovascular Diabetology

Myocardial insulin resistance, metabolic stress and autophagy in diabetes

(2012) Kimberley M Mellor et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Rapamycin Reduces Reactive Oxygen Species in Cultured Human Corneal Endothelial Cells

(2012) Young Joo Shin et al.   CURRENT EYE RESEARCH

Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway

(2012) Anindita Das et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Macrovascular Effects and Safety Issues of Therapies for Type 2 Diabetes

(2011) Jorge Plutzky   AMERICAN JOURNAL OF CARDIOLOGY

Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility

(2011) Ge Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy anomalies in the diabetic myocardium

(2011) Kimberley M. Mellor et al.   Autophagy

Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes

(2011) M.F. Essop et al.   Cardiovascular Journal of Africa

Oxidative stress and diabetes mellitus

(2011) Hui Yang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Long-term outcome after sirolimus-eluting stents versus bare metal stents in patients with Diabetes mellitus: a patient-level meta-analysis of randomized trials

(2011) Antoinette de Waha et al.   Clinical Research in Cardiology

Absence of altered autophagy after myocardial ischemia in diabetic compared with nondiabetic mice

(2011) Christopher J. French et al.   CORONARY ARTERY DISEASE

Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+signalling in young type 2 Zucker diabetic fatty rat heart

(2011) F. C. Howarth et al.   EXPERIMENTAL PHYSIOLOGY

Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

(2011) Kari T. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity

(2011) Lei Xi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

(2011) Kimberley M. Mellor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction

(2011) Miranda M. Y. Sung et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

(2011) B. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle

(2010) Joshua C. Drake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2010) Subat Turdi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis

(2010) Enkhsaikhan Purevjav et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

(2010) S. C. Ranieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonsense-Mediated mRNA Decay and Ubiquitin–Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice

(2009) Nicolas Vignier et al.   CIRCULATION RESEARCH

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes

(2008) Shigemiki Omiya et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY