Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

LKB1 couples glucose metabolism to insulin secretion in mice

(2015) Accalia Fu et al.   DIABETOLOGIA

The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells

(2015) Moran Choe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

(2015) Andreia V. Pinho et al.   PLoS One

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

The role of TRPM2 in pancreatic β-cells and the development of diabetes

(2014) Kunitoshi Uchida et al.   CELL CALCIUM

Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion

(2014) M. Yosida et al.   DIABETES

Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell

(2014) Justin S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression

(2013) Rongya Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6

(2013) Rongya Tao et al.   JOURNAL OF LIPID RESEARCH

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Complex Actions of Ionomycin in Cultured Cerebellar Astrocytes Affecting Both Calcium-Induced Calcium Release and Store-Operated Calcium Entry

(2013) Margit S. Müller et al.   NEUROCHEMICAL RESEARCH

Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis

(2013) Xiwen Xiong et al.   PLoS One

Multiple Regulatory Layers of SREBP1/2 by SIRT6

(2013) Sivan Elhanati et al.   Cell Reports

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses

(2012) Inga Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism

(2012) Xiwen Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

(2012) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

PPAR-γ Activation Restores Pancreatic Islet SERCA2 Levels and Prevents β-Cell Dysfunction under Conditions of Hyperglycemic and Cytokine Stress

(2012) Tatsuyoshi Kono et al.   MOLECULAR ENDOCRINOLOGY

Assessing Replication and Beta Cell Function in Adenovirally-transduced Isolated Rodent Islets

(2012) Patrick T. Fueger et al.   Jove-Journal of Visualized Experiments

Mouse Islet of Langerhans Isolation using a Combination of Purified Collagenase and Neutral Protease

(2012) Natalie D. Stull et al.   Jove-Journal of Visualized Experiments

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

Gelsolin Associates with the N Terminus of Syntaxin 4 to Regulate Insulin Granule Exocytosis

(2011) Michael A. Kalwat et al.   MOLECULAR ENDOCRINOLOGY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

(2010) B. Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

Noninvasive assessment of pancreatic β-cell function in vivo with manganese-enhanced magnetic resonance imaging

(2008) Patrick F. Antkowiak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE