Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice

PGE2-EP3 signaling exacerbates hippocampus-dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity-related proteins in aged mice

(2018) Jing-Yu Xiao et al.   CNS Neuroscience & Therapeutics

Raspberry Supplementation Improves Insulin Signaling and Promotes Brown-Like Adipocyte Development in White Adipose Tissue of Obese Mice

(2018) Tong Xing et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression

(2018) Sara A. Khedr et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Chronic Swimming Exercise Ameliorates Low-Soybean-Oil Diet-Induced Spatial Memory Impairment by Enhancing BDNF-Mediated Synaptic Potentiation in Developing Spontaneously Hypertensive Rats

(2018) Mei Cheng et al.   NEUROCHEMICAL RESEARCH

Resveratrol Boosts Cognitive Function by Targeting SIRT1

(2018) Wenyan Cao et al.   NEUROCHEMICAL RESEARCH

High-fat diet aggravates postoperative cognitive dysfunction in aged mice

(2018) Lan Wei et al.   BMC Anesthesiology

A p300 and SIRT1 Regulated Acetylation Switch of C/EBPα Controls Mitochondrial Function

(2018) Mohamad A. Zaini et al.   Cell Reports

Obesity, Cognitive Functioning and Dementia: Back to the Future

(2018) Merrill F. Elias et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of resveratrol pretreatment on endoplasmic reticulum stress and cognitive function after surgery in aged mice

(2018) Bei Wang et al.   BMC Anesthesiology

Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice

(2017) Nabanita Das et al.   JOURNAL OF PINEAL RESEARCH

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

(2017) Sarah J. Spencer et al.   NEUROBIOLOGY OF AGING

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial

(2017) Hamish Evans et al.   Nutrients

The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise

(2016) Ming Cai et al.   BRAIN BEHAVIOR AND IMMUNITY

Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same

(2016) Iris B. Hovens et al.   BRAIN BEHAVIOR AND IMMUNITY

Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway

(2016) V. Palomera-Avalos et al.   MOLECULAR NEUROBIOLOGY

Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

(2016) Ajit Vikram et al.   Nature Communications

Nox-2-Mediated Phenotype Loss of Hippocampal Parvalbumin Interneurons Might Contribute to Postoperative Cognitive Decline in Aging Mice

(2016) Li-Li Qiu et al.   Frontiers in Aging Neuroscience

Fndc5overexpression facilitated neural differentiation of mouse embryonic stem cells

(2015) Mahboobeh Forouzanfar et al.   CELL BIOLOGY INTERNATIONAL

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

(2015) Josep A. Villena   FEBS Journal

Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity

(2015) Rahul Agrawal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin

(2015) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

(2015) Susan L. Patterson   NEUROPHARMACOLOGY

Neuroprotective Effects of Intravenous Lidocaine on Early Postoperative Cognitive Dysfunction in Elderly Patients Following Spine Surgery

(2015) Jianjun Li   MEDICAL SCIENCE MONITOR

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

(2014) A. V. Witte et al.   JOURNAL OF NEUROSCIENCE

Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

(2014) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

(2014) Juan Carlos Corona et al.   NEUROCHEMICAL RESEARCH

High-mobility Group Box 1 Protein Initiates Postoperative Cognitive Decline by Engaging Bone Marrow–derived Macrophages

(2013) Susana Vacas et al.   ANESTHESIOLOGY

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Resveratrol Pretreatment Attenuates the Isoflurane-Induced Cognitive Impairment Through its Anti-Inflammation and -Apoptosis Actions in Aged Mice

(2013) Xiao-min Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration

(2013) J. Graff et al.   JOURNAL OF NEUROSCIENCE

Sirtuins in neurodegenerative diseases: an update on potential mechanisms

(2013) Sang-Won Min et al.   Frontiers in Aging Neuroscience

Obesity and the Elderly

(2012) Elisabeth MH Mathus-Vliegen   JOURNAL OF CLINICAL GASTROENTEROLOGY

Impairment of Fear-Conditioning Responses and Changes of Brain Neurotrophic Factors in Diet-Induced Obese Mice

(2012) N. Yamada-Goto et al.   JOURNAL OF NEUROENDOCRINOLOGY

Consumption of high-fat diet induces tumor progression and epithelial–mesenchymal transition of colorectal cancer in a mouse xenograft model

(2012) Feng-Yao Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Resolving postoperative neuroinflammation and cognitive decline

(2011) Niccolò Terrando et al.   ANNALS OF NEUROLOGY

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

(2011) Matteo Serino et al.   GUT

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila

(2010) Ryan T. Birse et al.   Cell Metabolism

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Cognitive dysfunction after surgery and anaesthesia: what can we tell the grandparents?

(2009) D. G. Seymour et al.   AGE AND AGEING

Predictors of Cognitive Dysfunction after Major Noncardiac Surgery

(2009) Terri G. Monk et al.   ANESTHESIOLOGY

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

(2008) Susan A. Farr et al.   ENDOCRINOLOGY

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY