Article
Cell Biology
Pu Xiang, Jian Hu, Hong Wang, Ying Luo, Chao Gu, Xiaodan Tan, Yujun Tu, Wenjia Guo, Lin Chen, Lin Gao, Rongchun Chen, Junqing Yang
Summary: This study found that the expression of miR-204-5p was significantly downregulated in patients with ischemic stroke, MCAO/R rat brains, and OGD/R neurons. Overexpression of miR-204-5p reduced infarct volume and neurological impairment and alleviated the inflammatory response. The TUG1/miR-204-5p/COX2 axis was involved in ischemia and reperfusion-induced neuronal damage.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Weiwei Wei, Xingquan Wang, Yaqing Wei, Shilin Liu, Shengyu Gao, Hao Tian, Dewang Su
Summary: The incidence of obesity and type 2 diabetes mellitus is increasing, threatening global health. Sleeve gastrectomy has become a common surgical approach for treating type 2 diabetes. Research has shown that the long non-coding RNA TUG1 can alleviate damage to intestinal epithelial cells under high glucose and high fat conditions by regulating protein expression levels.
MOLECULAR MEDICINE REPORTS
(2022)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The study retracts the article on the regulatory role of long non-coding RNA TUG1 in podocyte inflammation, fibrosis, and apoptosis in diabetic nephropathy.
Review
Chemistry, Medicinal
Mengzhen Xue, Fangqi Xia, Yaqi Wang, Leiqi Zhu, Yuanyang Li, Dengke Jia, Yan Gao, Yue Shi, Changcheng Zhang, Yumin He, Chaoqi Liu, Ding Yuan, Chengfu Yuan
Summary: As people's living standards improve, obesity has become a focus. TUG1 is related to the occurrence and development of obesity-related diseases, while exosomes play a role in regulating disease molecular mechanisms.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Shaoqiang Wang, Pengfei Yi, Na Wang, Min Song, Wenhui Li, Yingying Zheng
Summary: In this study, it was found that TUG1 could inhibit apoptosis mediated by ERS by negatively regulating miR-29c-3p, while miR-29c-3p could increase ERS and decrease the level of SIRT1, resulting in injury to HK-2 cells induced by high glucose.
Article
Cell Biology
Etsu Tashiro, Yumi Nagasawa, Susumu Itoh, Masaya Imoto
Summary: Insulin resistance is closely related to metabolic disorders, primarily due to elevated plasma free fatty acid levels. Palmitic acid-induced increase in miRNAs suppresses insulin signaling, leading to insulin resistance.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biology
Adam J. Trewin, Jessica Silver, Hayley T. Dillon, Paul A. Della Gatta, Lewan Parker, Danielle S. Hiam, Yin Peng Lee, Mark Richardson, Glenn D. Wadley, Severine Lamon
Summary: The study found that lncRNA Tug 1 is upregulated in human skeletal muscle after a single session of exercise. Tug 1 regulates transcriptional networks associated with mitochondrial calcium handling, muscle differentiation, and myogenesis.
Article
Oncology
Miao-Xian Yuan, Chun-Yi Ji, Hong-Qiang Gao, Xin-Yi Sheng, Wei-Xin Xie, Qiang Yin
Summary: The study revealed that TUG1 was upregulated and miR-204-5p was downregulated in hepatoblastoma tissues and cells. TUG1 inhibited the suppressive effect of miR-204-5p on the JAK2/STAT3 pathway, thereby promoting angiogenesis in hepatoblastoma cells. These findings suggest novel targets for hepatoblastoma treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Agriculture, Multidisciplinary
Sihuan Zhang, Enhui Jiang, Zihong Kang, Yi Bi, Hongfei Liu, Han Xu, Zhen Wang, Chuzhao Lei, Hong Chen, Xianyong Lan
Summary: This study found that circBDP1 overexpression promotes the proliferation and differentiation of bovine preadipocytes. In addition, miR-181b and miR-204 are involved in fat development by targeting SIRT1 and TRARG1.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xiaoyan Lv, Yali Zhao, Xuehan Yang, Hao Han, Yue Ge, Meishuang Zhang, Hansi Zhang, Ming Zhang, Li Chen
Summary: The study reveals a novel correlation between miR-204 and beta-cell dysfunction in T2DM, and shows that BBR treatment leads to remission of beta-cell dysfunction by regulating the miR-204/SIRT1 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yu-jie Xing, Teng Zhang, Shu-jun Wan, Yi Cheng, Si -min Zhou, Yue Sun, Hao-ran Zhang, Xin-ming Yao, Qiang Hua, Xiang-jian Meng, Yan Zhang, Kun Lv, Chunxiao Li, Xiang Kong
Summary: This study investigated the role of a new long non-coding RNA called HEM2ATM in modulating obesity-associated meta-inflammation and insulin resistance. HEM2ATM was found to be decreased in adipose tissue macrophages obtained from obese mice. Overexpression of macrophage HEM2ATM improved meta-inflammation and insulin resistance in obese mice. Mechanistically, HEM2ATM negatively regulated the production of pro-inflammatory cytokines in macrophages.
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xianqiu Wu, Yang Liu, Song Mo, Wuli Wei, Ziliang Ye, Qiang Su
Summary: The study revealed the significance of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 axes in MIRI, promoting myocardial ischemia-reperfusion injury by affecting cell survival and apoptosis.
Article
Cell & Tissue Engineering
Daokun Li, Juan Peng, Jian Ran
Summary: LINC01094 promotes cell proliferation in glioma cells through regulation of miR-204-3p.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
Article
Medicine, Research & Experimental
Niketa A. Patel, Ashley Lui, Andrea N. Trujillo, Zeinab Y. Motawe, Deena Bader, Jane Schuster, Andrea Burgess, Natascha G. Alves, Michiko Jo, Jerome W. Breslin
Summary: This study identified mediators in the peri-lymphatic adipose tissue (PLAT) that are altered in obese versus lean Zucker rats, with a focus on potential sex differences. It was found that obese male and female rats show increased inflammation, but they have distinct signals in terms of protein and lncRNA expression. These findings provide valuable insights for the development of therapeutics for obesity-induced inflammation.
Article
Neurosciences
Hui-Ting Huang, Chih-Yen Wang, Chia-Hsin Ho, Shun-Fen Tzeng
Summary: Oligodendrocytes (OLs) form myelin sheaths in the central nervous system (CNS) and microRNA (miR) regulation, specifically miR-204, plays a crucial role in OL differentiation. In this study, the expression of miR-204 and its interaction with interleukin-6 (IL-6) in OLs were investigated. The findings suggest that miR-204-5p expression is suppressed by IL-6 and the inflamed microenvironment, while increased miR-204-5p and reduced IL-6 expression may be involved in OL repair and homeostasis following white matter injury.
MOLECULAR NEUROBIOLOGY
(2023)