SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion

(2017) Jarrett R. Remsberg et al.   Molecular Metabolism

Are epigenetic drugs for diabetes and obesity at our door step?

(2016) Andrix O. Arguelles et al.   DRUG DISCOVERY TODAY

Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney

(2016) Yang De Marinis et al.   KIDNEY INTERNATIONAL

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

(2016) Mi-Young Song et al.   Scientific Reports

Phenotypic Characterization of MIP-CreERT1LphiMice With Transgene-Driven Islet Expression of Human Growth Hormone

(2015) Daniel Oropeza et al.   DIABETES

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

(2015) Xiwen Xiong et al.   DIABETOLOGIA

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

(2015) Jean-Pierre Etchegaray et al.   NATURE CELL BIOLOGY

Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective

(2015) Francesco Zaccardi et al.   POSTGRADUATE MEDICAL JOURNAL

A systems view of epigenetic networks regulating pancreas development and β-cell function

(2015) Ruiyu Xie et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

(2014) Bas Brouwers et al.   Cell Metabolism

Minireview: Thioredoxin-Interacting Protein: Regulation and Function in the Pancreatic β-Cell

(2014) Anath Shalev   MOLECULAR ENDOCRINOLOGY

Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells

(2014) Yan Luo et al.   PLoS One

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes

(2014) Haihui Pan et al.   Cell Reports

An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development

(2014) Cecil M. Benitez et al.   PLoS Genetics

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

(2014) Joshua C. Neuman et al.   Jove-Journal of Visualized Experiments

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

Preventing  -Cell Loss and Diabetes With Calcium Channel Blockers

(2012) G. Xu et al.   DIABETES

Disruption of Growth Factor Receptor-Binding Protein 10 in the Pancreas Enhances  -Cell Proliferation and Protects Mice From Streptozotocin-Induced  -Cell Apoptosis

(2012) J. Zhang et al.   DIABETES

Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice

(2012) Rachel B. Reinert et al.   PLoS One

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models

(2011) M C Deeds et al.   LABORATORY ANIMALS

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Decreasing Txnip mRNA and Protein Levels in Pancreatic MIN6 Cells Reduces Reactive Oxygen Species and Restores Glucose Regulated Insulin Secretion

(2010) Sweta Rani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity

(2010) Eiji Yoshihara et al.   Nature Communications

Tandem ChoRE and CCAAT Motifs and Associated Factors Regulate Txnip Expression in Response to Glucose or Adenosine-Containing Molecules

(2009) Fa-Xing Yu et al.   PLoS One

Genetic background determines metabolic phenotypes in the mouse

(2008) Marie-France Champy et al.   MAMMALIAN GENOME

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

A rapid micro chromatin immunoprecipitation assay (ChIP)

(2008) John Arne Dahl et al.   Nature Protocols

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS