SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

(2018) Gaia Botteri et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3

(2018) Karina N. Gonzalez Herrera et al.   Cell Reports

HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver

(2018) Takatomo Arai et al.   Scientific Reports

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

(2017) Robert A.H. van de Ven et al.   TRENDS IN MOLECULAR MEDICINE

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α

(2016) Nan Hu et al.   Oncotarget

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice

(2016) Fenni Rusli et al.   Scientific Reports

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

(2015) Sanjaya Satapathy et al.   SEMINARS IN LIVER DISEASE

Identification of novel SIRT3 inhibitor scaffolds by virtual screening

(2013) Heikki S. Salo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Redox Homeostasis and Epigenetics in Non-alcoholic Fatty Liver Disease (NAFLD)

(2013) Christine Podrini et al.   CURRENT PHARMACEUTICAL DESIGN

Nuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice

(2013) Zhigang Wang et al.   HEPATOLOGY

High insulin levels are required for FAT/CD36 plasma membrane translocation and enhanced fatty acid uptake in obese Zucker rat hepatocytes

(2012) Xabier Buqué et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression

(2012) I. Mylonis et al.   JOURNAL OF CELL SCIENCE

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia

(2011) Guo-Min Shen et al.   BIOCHEMICAL JOURNAL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

(2011) Yasumasa Nishiyama et al.   JOURNAL OF HEPATOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

(2010) Jianjun Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Peroxisome proliferator-activated receptor-γ regulates the expression and function of very-low-density lipoprotein receptor

(2009) Huan Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

(2008) Atsushi Maruyama et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes

(2008) Massimo D'Archivio et al.   FEBS LETTERS

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

(2008) G MUSSO et al.   PROGRESS IN LIPID RESEARCH