Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons

NAD metabolism: Implications in aging and longevity

(2018) Keisuke Yaku et al.   AGEING RESEARCH REVIEWS

Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis

(2018) Gurdeep Marwarha et al.   JOURNAL OF NEUROCHEMISTRY

Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE(2)-M17 cells

(2018) Yun Shi et al.   NUTRITION RESEARCH

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4

(2018) Domenico Sergi et al.   NUTRITIONAL NEUROSCIENCE

The Saturated Fatty Acid Palmitate Induces Human Monocytic Cell Toxicity Toward Neuronal Cells: Exploring a Possible Link Between Obesity-Related Metabolic Impairments and Neuroinflammation

(2018) Jonathan P. Little et al.   JOURNAL OF ALZHEIMERS DISEASE

Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production

(2017) Erika Calvo-Ochoa et al.   NEUROCHEMISTRY INTERNATIONAL

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

(2017) Robert J. Andrew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

(2016) Gurdeep Marwarha et al.   CELLULAR SIGNALLING

Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults

(2016) Siobhan M. Hoscheidt et al.   JOURNAL OF ALZHEIMERS DISEASE

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

(2016) Saoussen Ben Halima et al.   Cell Reports

Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity

(2015) Alberto Díaz-Ruiz et al.   ANTIOXIDANTS & REDOX SIGNALING

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

(2014) Gurdeep Marwarha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells

(2014) Bumsup Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Palmitic Acid-Induced Neuron Cell Cycle G2/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells

(2014) Yung-Hsuan Hsiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DrosophilaSirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

(2014) Motiur Rahman et al.   JOURNAL OF CELL BIOLOGY

Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease

(2014) Mirjam I. Lutz et al.   NEUROMOLECULAR MEDICINE

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway

(2013) L. Cao et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1

(2013) Minzi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sirtuin1: A Promising Serum Protein Marker for Early Detection of Alzheimer’s Disease

(2013) Rahul Kumar et al.   PLoS One

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Sirtuins in cognitive ageing and Alzheimerʼs disease

(2012) Nady Braidy et al.   CURRENT OPINION IN PSYCHIATRY

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Screening Cognition in the Elderly with Metabolic Syndrome

(2012) Giovanni Viscogliosi et al.   Metabolic Syndrome and Related Disorders

Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases

(2012) Li Liu et al.   NEUROBIOLOGY OF AGING

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Encephalopathies: the emerging diabetic complications

(2010) Anders A. F. Sima   ACTA DIABETOLOGICA

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

(2010) S. V. de Kreutzenberg et al.   DIABETES

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration?

(2009) H. Umegaki   AGE AND AGEING

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

(2009) Jesse J Smith et al.   BMC Systems Biology

Cellular Regulation of SIRT1

(2009) Jo Milner   CURRENT PHARMACEUTICAL DESIGN

Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer’s Disease

(2009) Thomas Fraser et al.   NEUROCHEMICAL RESEARCH