Inhibition of SIRT2 suppresses hepatic fibrosis

Sirt2 induces C2C12 myoblasts proliferation by activation of the ERK1/2 pathway

(2014) Guofang Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

FAK Is required for c-Met/β-catenin-driven hepatocarcinogenesis

(2014) Na Shang et al.   HEPATOLOGY

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

(2013) Yulia A. Nevzorova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PEP-1–SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages

(2013) Mi Jin Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

(2013) Juan Chen et al.   HEPATOLOGY

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

(2012) P Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches

(2011) Elisabetta Mormone et al.   CHEMICO-BIOLOGICAL INTERACTIONS

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice

(2011) Wei Qiu et al.   HEPATOLOGY

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4

(2010) Lan Qin et al.   AMERICAN JOURNAL OF PATHOLOGY

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

(2010) Ahmed M. Elsharkawy et al.   JOURNAL OF HEPATOLOGY

Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity

(2009) Yingjia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses

(2008) Jinsheng Guo et al.   HEPATOLOGY

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

(2008) Ruwin Pandithage et al.   JOURNAL OF CELL BIOLOGY

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE