Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

(2020) Anna Śledzińska et al.   IMMUNITY

A cell atlas of human thymic development defines T cell repertoire formation

(2020) Jong-Eun Park et al.   SCIENCE

Neoadjuvant checkpoint blockade for cancer immunotherapy

(2020) Suzanne L. Topalian et al.   SCIENCE

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

(2020) Hassen Kared et al.   Nature Communications

Physical Activity and Diet Shape the Immune System during Aging

(2020) Christopher Weyh et al.   Nutrients

Aging-induced IL27Ra Signaling Impairs Hematopoietic Stem Cells

(2020) Hanqing He et al.   BLOOD

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Neonatal thymectomy in children—accelerating the immunologic clock?

(2020) Angela Deya-Martinez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Can blocking inflammation enhance immunity during aging?

(2020) Emma S. Chambers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

T cell subsets and functions in atherosclerosis

(2020) Ryosuke Saigusa et al.   Nature Reviews Cardiology

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness

(2020) Maria Conte et al.   Frontiers in Immunology

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

(2020) David Y. Oh et al.   CELL

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

(2019) Matthew D. Taves et al.   Cell Reports

Age-dependent decline in neurogenesis of the hippocampus and extracellular nucleotides

(2019) Yoshinori Takei   Human Cell

Age-related inflammation triggers skeletal stem/progenitor cell dysfunction

(2019) Anne Marie Josephson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Are skin senescence and immunosenescence linked within individuals?

(2019) Mariëtte E. C. Waaijer et al.   AGING CELL

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Restored immune cell functions upon clearance of senescence in the irradiated splenic environment

(2019) Lina Palacio et al.   AGING CELL

Metabolic reprogramming in memory CD4 T cell responses of old adults

(2019) Rolando E. Yanes et al.   CLINICAL IMMUNOLOGY

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

(2019) Ailin Lepletier et al.   Cell Reports

Location, location, location: Tissue resident memory T cells in mice and humans

(2019) Peter A. Szabo et al.   Science Immunology

Immunology of the ageing kidney

(2019) Yuki Sato et al.   Nature Reviews Nephrology

Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation

(2019) Chenyang Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

(2019) Yehezqel Elyahu et al.   Science Advances

Rapamycin for longevity: opinion article

(2019) Mikhail V. Blagosklonny   Aging-US

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

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Intestinal Stem Cell Aging: Origins and Interventions

(2019) Heinrich Jasper   Annual Review of Physiology

Cellular Senescence: Defining a Path Forward

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Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing

(2019) Salah Mahmoudi et al.   NATURE

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

The genetics of human ageing

(2019) David Melzer et al.   NATURE REVIEWS GENETICS

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

(2019) Kosuke Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Effects of Intermittent Fasting on Health, Aging, and Disease

(2019) Rafael de Cabo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register

(2019) Katie Bechman et al.   RHEUMATOLOGY

Senescent cell turnover slows with age providing an explanation for the Gompertz law

(2019) Omer Karin et al.   Nature Communications

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

(2018) Claudio Franceschi et al.   Annual Review of Nutrition

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging

(2018) Peggie Cheung et al.   CELL

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

Age and immunity: What is “immunosenescence”?

(2018) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Memory CD8 T cell inflation vs tissue-resident memory T cells: Same patrollers, same controllers?

(2018) Suzanne P. M. Welten et al.   IMMUNOLOGICAL REVIEWS

The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination

(2018) Joshua I. Gray et al.   IMMUNOLOGY

Intrathymic Deletion of IL-7 Reveals a Contribution of the Bone Marrow to Thymic Rebound Induced by Androgen Blockade

(2018) Pedro M. Rodrigues et al.   JOURNAL OF IMMUNOLOGY

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Thymic involution and rising disease incidence with age

(2018) Sam Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of CD4 T cell memory by local cellular collectivity

(2018) Michal Polonsky et al.   SCIENCE

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Three-Dimensional Ameliorated Biologics Elicit Thymic Renewal in Tumor-Bearing Hosts

(2018) Yanna Zhang et al.   JOURNAL OF IMMUNOLOGY

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

(2018) James M. Wells et al.   NATURE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Immunomodulation of Tumor Vessels: It Takes Two to Tango

(2018) Anna Johansson-Percival et al.   TRENDS IN IMMUNOLOGY

The potential nutrigeroprotective role of Mediterranean diet and its functional components on telomere length dynamics

(2018) Sergio Davinelli et al.   AGEING RESEARCH REVIEWS

Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis

(2018) Aline Carla Araújo Carvalho et al.   AGEING RESEARCH REVIEWS

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

(2018) Mikolaj Ogrodnik et al.   AGING CELL

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

(2018) Heather L. Thompson et al.   AGING CELL

Immune and Genetic Features of the Chromosome 22q11.2 Deletion (DiGeorge Syndrome)

(2018) Caroline Y. Kuo et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Successful and Maladaptive T Cell Aging

(2017) Jörg J. Goronzy et al.   IMMUNITY

The effect of tumor necrosis factor inhibitor therapy on the incidence of myocardial infarction in patients with psoriasis: a retrospective study

(2017) Dalia Shaaban et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

(2017) David Furman et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Aging increases cell-to-cell transcriptional variability upon immune stimulation

(2017) Celia Pilar Martinez-Jimenez et al.   SCIENCE

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

The Mechanisms of T Cell Selection in the Thymus

(2017) Hiroyuki Takaba et al.   TRENDS IN IMMUNOLOGY

Cancer and Aging - the Inflammatory Connection

(2017) Adar Zinger et al.   Aging and Disease

Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression

(2017) Idan Harpaz et al.   Frontiers in Immunology

Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?

(2017) Jennifer A. Juno et al.   Frontiers in Immunology

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin

(2016) Brice E. Keyes et al.   CELL

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

Thymus: the next (re)generation

(2016) Mohammed S. Chaudhry et al.   IMMUNOLOGICAL REVIEWS

Early thymectomy leads to premature immunologic ageing: An 18-year follow-up

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Clonal expansion of CD4 + cytotoxic T lymphocytes in patients with IgG 4 -related disease

(2016) Hamid Mattoo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

(2016) Saulius Žuklys et al.   NATURE IMMUNOLOGY

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

(2016) Celine Boutros et al.   Nature Reviews Clinical Oncology

Individual variability in human blood metabolites identifies age-related differences

(2016) Romanas Chaleckis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

(2016) Yun-Hee Youm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

(2016) Fengqin Fang et al.   Cell Reports

Systemic inflammation, body composition, and physical performance in old community-dwellers

(2016) Riccardo Calvani et al.   Journal of Cachexia Sarcopenia and Muscle

The aged lymphoid tissue environment fails to support naïve T cell homeostasis

(2016) Bryan R. Becklund et al.   Scientific Reports

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

(2015) T. Fulop et al.   BIOGERONTOLOGY

Sex steroid ablation: an immunoregenerative strategy for immunocompromised patients

(2015) E Velardi et al.   BONE MARROW TRANSPLANTATION

Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance

(2015) Angela R. Manser et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunosuppression associated with chronic inflammation in the tumor microenvironment

(2015) Dingzhi Wang et al.   CARCINOGENESIS

Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

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Dynamics and Mechanisms of CNS Myelination

(2015) Kathryn K. Bercury et al.   DEVELOPMENTAL CELL

Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus

(2015) Immanuel Rode et al.   JOURNAL OF IMMUNOLOGY

Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

(2015) Brandon D. Coder et al.   JOURNAL OF IMMUNOLOGY

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(2015) Michael T Heneka et al.   LANCET NEUROLOGY

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?

(2015) Robert W. Elder et al.   PEDIATRIC CARDIOLOGY

Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+T cells associated with protective immunity

(2015) Daniela Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice

(2015) Thea Hogan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging concepts in tissue-resident T cells: lessons from humans

(2015) Joseph J.C. Thome et al.   TRENDS IN IMMUNOLOGY

HSC Aging and Senescent Immune Remodeling

(2015) Michael D. Denkinger et al.   TRENDS IN IMMUNOLOGY

Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

(2015) Ben J. E. Raveney et al.   Nature Communications

Hantaan Virus Infection Induces Both Th1 and ThGranzyme B+ Cell Immune Responses That Associated with Viral Control and Clinical Outcome in Humans

(2015) Ying Ma et al.   PLoS Pathogens

Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation

(2015) Maria Danielma dos Santos Reis et al.   Immunity & Ageing

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

PD-1 and Tim-3 Pathways Regulate CD8+ T Cells Function in Atherosclerosis

(2015) Ming-Ke Qiu et al.   PLoS One

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression

(2014) Maïté Rielland et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories

(2014) Janko Nikolich-Žugich   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

CD4:8 Ratio >5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study

(2014) Wim Adriaensen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

(2014) Nicholas Bredenkamp et al.   NATURE CELL BIOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Thymus and aging: morphological, radiological, and functional overview

(2013) Rita Rezzani et al.   AGE

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

The Hallmarks of Aging

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From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

(2013) Anis Larbi et al.   CYTOMETRY PART A

Immunosenenescence: Role of cytomegalovirus

(2013) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

Differential homeostatic dynamics of human regulatory T-cell subsets following neonatal thymectomy

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Causes, consequences, and reversal of immune system aging

(2013) Encarnacion Montecino-Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

When aging reaches CD4+ T-cells: phenotypic and functional changes

(2013) Marco Antonio Moro-García   Frontiers in Immunology

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

High Levels of Costimulatory Receptors OX40 and 4-1BB Characterize CD4 + CD28 null T Cells in Patients With Acute Coronary Syndrome

(2012) Ingrid E. Dumitriu et al.   CIRCULATION RESEARCH

Evolution of thymus organogenesis

(2012) Qing Ge et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Age-related variation in immunity in a wild mammal population

(2011) Daniel H. Nussey et al.   AGING CELL

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

(2011) E. C. Zook et al.   BLOOD

Altered thymic activity in early life: how does it affect the immune system in young adults?

(2011) Delphine Sauce et al.   CURRENT OPINION IN IMMUNOLOGY

A thymus candidate in lampreys

(2011) Baubak Bajoghli et al.   NATURE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α

(2011) Yi Liu et al.   NATURE MEDICINE

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Impact of age on T cell signaling: A general defect or specific alterations?

(2010) Anis Larbi et al.   AGEING RESEARCH REVIEWS

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Evidence of premature immune aging in patients thymectomized during early childhood

(2009) Delphine Sauce et al.   JOURNAL OF CLINICAL INVESTIGATION

Sex Steroid Ablation Enhances Hematopoietic Recovery following Cytotoxic Antineoplastic Therapy in Aged Mice

(2009) J. A. Dudakov et al.   JOURNAL OF IMMUNOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

PD-1+ memory phenotype CD4+ T cells expressing C/EBP  underlie T cell immunodepression in senescence and leukemia

(2009) K. Shimatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2008)   ARCHIVES OF NEUROLOGY

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

(2008) L. Chen et al.   BLOOD

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation