Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

Cellular Senescence in Ageing, Age-Related Disease and Longevity

(2014) Ewa Sikora et al.   Current Vascular Pharmacology

Mast cells protect from skin tumor development and limit tumor growth during cutaneousde novocarcinogenesis in a Kit-dependent mouse model

(2014) Frank Siebenhaar et al.   EXPERIMENTAL DERMATOLOGY

Skin Cancers in Elderly Patients

(2013) Giulia Malaguarnera et al.   Anti-Cancer Agents in Medicinal Chemistry

Expression and significance of HMGB1, TLR4 and NF-κB p65 in human epidermal tumors

(2013) Hui Weng et al.   BMC CANCER

Dynamics of Senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis

(2013) R. Tokarsky-Amiel et al.   CANCER RESEARCH

PD-1 blockage delays murine squamous cell carcinoma development

(2013) E. B. Belai et al.   CARCINOGENESIS

Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos

(2013) E. M. Briso et al.   GENES & DEVELOPMENT

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

(2013) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

Causes, consequences, and reversal of immune system aging

(2013) Encarnacion Montecino-Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Tracing the cellular origin of cancer

(2013) Cédric Blanpain   NATURE CELL BIOLOGY

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

TNF-alpha is a key mediator in the development of Th2 cell response to inhaled allergens induced by a viral PAMP double-stranded RNA

(2012) J.-P. Choi et al.   ALLERGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting

(2012) Matteo Di Piazza et al.   CANCER CELL

Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

(2012) Bing Hu et al.   CELL

Normal ageing is associated with an increase in Th2 cells, MCP-1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF-AA between sexes

(2012) A. S. Mansfield et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Age-associated inflammation inhibits epidermal stem cell function

(2012) J. Doles et al.   GENES & DEVELOPMENT

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

Cyclin E drives human keratinocyte growth into differentiation

(2012) A Freije et al.   ONCOGENE

Expression of Mast Cell Proteases Correlates with Mast Cell Maturation and Angiogenesis during Tumor Progression

(2012) Devandir Antonio de Souza et al.   PLoS One

Comparative kinetic analyses of gene profiles of naïve CD4+and CD8+T cells from young and old animals reveal novel age-related alterations

(2011) Noweeda Mirza et al.   AGING CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

(2011) Wen-Hui Lien et al.   Cell Stem Cell

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Identifying the cellular origin of squamous skin tumors

(2011) G. Lapouge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells

(2010) Deepak Mittal et al.   EMBO JOURNAL

Immunosenescence: what does it mean to health outcomes in older adults?

(2009) Janet E McElhaney et al.   CURRENT OPINION IN IMMUNOLOGY

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

T-cell immunosenescence: lessons learned from mouse models of aging

(2009) Alexander C. Maue et al.   TRENDS IN IMMUNOLOGY

Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion

(2008) C. L. Montes et al.   CANCER RESEARCH

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

(2008) Byung Eui Kim et al.   CLINICAL IMMUNOLOGY

Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation

(2008) Michael D. Howell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY