GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness

Elevated Plasma Growth and Differentiation Factor-15 is Associated with Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults

(2019) Richard D Semba et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection

(2019) Gerd Jomrich et al.   JOURNAL OF GASTROINTESTINAL SURGERY

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions

(2019) Guillaume Ha et al.   PLoS One

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients

(2019) Nakajima et al.   Journal of Clinical Medicine

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice

(2019) Carla Igual Gil et al.   Scientific Reports

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse

(2018) Takashi Ito et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Human Aging and Longevity Are Characterized by High Levels of Mitokines

(2018) Maria Conte et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Exercise increases circulating GDF15 in humans

(2018) Maximilian Kleinert et al.   Molecular Metabolism

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Reference values for white blood-cell-based inflammatory markers in the Rotterdam Study: a population-based prospective cohort study

(2018) Jesse Fest et al.   Scientific Reports

Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension

(2018) Benjamin E Garfield et al.   THORAX

GDF15 and Growth Control

(2018) Paul J. Emmerson et al.   Frontiers in Physiology

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury

(2017) Hyo Kyun Chung et al.   Scientific Reports

Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders

(2016) Yasunori Fujita et al.   Geriatrics & Gerontology International

Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

(2016) Min Young Shin et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Inflammatory and Adipose Response in Solid Organ Transplant Recipients After a Marathon Cycling Race

(2016) M. Cappuccilli et al.   TRANSPLANTATION PROCEEDINGS

Can Solid-Organ–Transplanted Patients Perform a Cycling Marathon? Trends in Kidney Function Parameters in Comparison With Healthy Subjects

(2016) G. Mosconi et al.   TRANSPLANTATION PROCEEDINGS

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

(2016) Xingya Wang et al.   Aging-US

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

(2015) Marlene Hofmann et al.   EXPERIMENTAL GERONTOLOGY

Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wastingin vivo

(2015) Mehul S. Patel et al.   Journal of Cachexia Sarcopenia and Muscle

GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

(2015) Ramu Adela et al.   Journal of Diabetes Research

Acute exercise in elite rugby players increases the circulating level of the cardiovascular biomarker GDF-15

(2014) Emanuela Galliera et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Increased Plin2 Expression in Human Skeletal Muscle Is Associated with Sarcopenia and Muscle Weakness

(2013) Maria Conte et al.   PLoS One

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

(2011) Tibor Kempf et al.   NATURE MEDICINE

Growth differentiation factor 15 acts anti-apoptotic and pro-hypertrophic in adult cardiomyocytes

(2010) J. Heger et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Growth-differentiation factor-15, endoglin and N-terminal pro-brain natriuretic peptide induction in athletes participating in an ultramarathon foot race

(2009) Isabelle Tchou et al.   BIOMARKERS