Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Senotherapeutics for healthy ageing

(2018) Laura J. Niedernhofer et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular and epigenetic drivers of stem cell ageing

(2018) Maria Ermolaeva et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Aging increases cell-to-cell transcriptional variability upon immune stimulation

(2017) Celia Pilar Martinez-Jimenez et al.   SCIENCE

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

PARP, transcription and chromatin modeling

(2017) Melanija Posavec Marjanović et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Age-associated molecular changes are deleterious and may modulate life span through diet

(2017) Sang-Goo Lee et al.   Science Advances

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

(2016) Vadim N. Gladyshev   AGING CELL

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

(2016) Hannah E. Walters et al.   Aging-US

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

(2016) Satomi Miwa et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF

(2016) Su Yeon Han et al.   CANCER RESEARCH

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

(2016) Allyson K. Palmer et al.   EXPERIMENTAL GERONTOLOGY

Increased Protein Stability and Decreased Protein Turnover in theCaenorhabditis elegansIns/IGF-1daf-2Mutant

(2016) Geert Depuydt et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

(2016) Young Sung Yun et al.   MOLECULAR CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing

(2016) Margaret L. Hoang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Old Proteins in Man: A Field in its Infancy

(2016) Roger J.W. Truscott et al.   TRENDS IN BIOCHEMICAL SCIENCES

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Metformin: A Hopeful Promise in Aging Research

(2016) Marta G. Novelle et al.   Cold Spring Harbor Perspectives in Medicine

Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains

(2016) Candice L. Brinkmeyer-Langford et al.   Frontiers in Aging Neuroscience

Quality and quantity control of proteins in senescence

(2016) Masashi Narita   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling

(2016) Yuyani Xiong et al.   Aging-US

Evidence that mutation accumulation does not cause aging inSaccharomyces cerevisiae

(2015) Alaattin Kaya et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

(2015) Jodie Birch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction

(2015) Florie A Mar et al.   Autophagy

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts

(2015) Fee Bengsch et al.   CELL CYCLE

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

(2015) Peter D. Adams et al.   Cell Stem Cell

Exogenous Superoxide Dismutase Mimetic Without Scavenging H2O2 Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy

(2015) S. Jivabhai Patel et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

In vivo kinetic approach reveals slow SOD1 turnover in the CNS

(2015) Matthew J. Crisp et al.   JOURNAL OF CLINICAL INVESTIGATION

Unraveling the non-senescence phenomenon in Hydra

(2015) Maciej J. Dańko et al.   JOURNAL OF THEORETICAL BIOLOGY

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

(2015) Ryan R. White et al.   Nature Communications

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

(2015) Nana Akagi Tsuchihashi et al.   Oncotarget

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality

(2015) Sunitha Rangaraju et al.   eLife

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres

(2014) J. Wang et al.   BLOOD

Repair rather than segregation of damage is the optimal unicellular aging strategy

(2014) Robert J Clegg et al.   BMC BIOLOGY

Cellular senescence and protein degradation

(2014) Xavier Deschênes-Simard et al.   CELL CYCLE

Hydrogen peroxide primes heart regeneration with a derepression mechanism

(2014) Peidong Han et al.   CELL RESEARCH

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions

(2014) Ya-Nan Guo et al.   EXPERIMENTAL GERONTOLOGY

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage

(2014) Andrew M. Pickering et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

(2014) M. Ogrodnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Markers of Oxidative Stress in Senescent Erythrocytes Obtained from Young and Old Age Rats

(2014) Dileep Kumar et al.   REJUVENATION RESEARCH

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Aggresome formation is regulated by RanBPM through an interaction with HDAC6

(2014) L. M. Salemi et al.   Biology Open

Macroautophagy and the Oncogene-Induced Senescence

(2014) Daniel Grasso et al.   Frontiers in Endocrinology

Superior proteome stability in the longest lived animal

(2013) S. B. Treaster et al.   AGE

Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin

(2013) Anna Litwiniec et al.   Cancer Cell International

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Aging is not programmed

(2013) Mikhail V Blagosklonny   CELL CYCLE

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

The asymmetric segregation of damaged proteins is stem cell–type dependent

(2013) Mary Rose Bufalino et al.   JOURNAL OF CELL BIOLOGY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?

(2013) Subhankar Paul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Branched-Chain Amino Acids Enhance Premature Senescence through Mammalian Target of Rapamycin Complex I-Mediated Upregulation of p21 Protein

(2013) Masayuki Nakano et al.   PLoS One

Nutrient Signaling in Protein Homeostasis: An Increase in Quantity at the Expense of Quality

(2013) C. S. Conn et al.   Science Signaling

The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan

(2013) Vadim N. Gladyshev   TRENDS IN GENETICS

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

(2012) David Gems et al.   ANTIOXIDANTS & REDOX SIGNALING

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

The profile of lysosomal exoglycosidases in replicative and stress-induced senescence in early passage human fibroblasts

(2012) Małgorzata Knaś et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Lymphangioleiomyomatosis — a wolf in sheep’s clothing

(2012) Elizabeth P. Henske et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Autophagy and Lipofuscin Accumulation in Aging Odontoblasts

(2012) E. Couve et al.   JOURNAL OF DENTAL RESEARCH

SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence

(2012) Sifang Zhang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Protein homeostasis: live long, won't prosper

(2012) Brandon H. Toyama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain

(2012) J. N. Savas et al.   SCIENCE

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

An Engineering Approach to Extending Lifespan in C. elegans

(2012) Dror Sagi et al.   PLoS Genetics

Spatio-temporal association between mTOR and autophagy during cellular senescence

(2011) Andrew R.J. Young et al.   Autophagy

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

SRSF2 is required for sodium butyrate-mediated p21WAF1 induction and premature senescence in human lung carcinoma cell lines

(2011) Valerie Edmond et al.   CELL CYCLE

Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment

(2011) Shinichi Usui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice

(2011) V. I. Perez et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Biomarkers of aging in Drosophila

(2010) Jake Jacobson et al.   AGING CELL

Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

(2010) Michelle Gracanin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1

(2010) Aswin Mangerich et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lens aging: Effects of crystallins

(2009) K. Krishna Sharma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

When a theory of aging ages badly

(2009) Jérôme Lapointe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis

(2009) Adam B. Salmon et al.   FASEB JOURNAL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-livedMclk1+/−Mice

(2009) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

(2009) Lucinda K. Southworth et al.   PLoS Genetics

Detoxification reactions: Relevance to aging

(2008) Piotr Zimniak   AGEING RESEARCH REVIEWS

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

DNA double-strand breaks: A potential causative factor for mammalian aging?

(2008) Han Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS