Hantaan Virus Infection Induces Both Th1 and ThGranzyme B+ Cell Immune Responses That Associated with Viral Control and Clinical Outcome in Humans

CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent

(2014) Wenliang Zhang et al.   EXPERIMENTAL GERONTOLOGY

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

(2014) Ryoji Yagi et al.   IMMUNITY

Inflammatory Cytokines Drive CD4+ T-Cell Cycling and Impaired Responsiveness to Interleukin 7: Implications for Immune Failure in HIV Disease

(2014) Carey L. Shive et al.   JOURNAL OF INFECTIOUS DISEASES

Involvement of Different CD4+T Cell Subsets Producing Granzyme B in the Immune Response toLeishmania majorAntigens

(2014) Ikbel Naouar et al.   MEDIATORS OF INFLAMMATION

Inflammation Enhances IL-2 Driven Differentiation of Cytolytic CD4 T Cells

(2014) Aspen M. Workman et al.   PLoS One

Adaptive immune response during hepatitis C virus infection

(2014) Juan Ramón Larrubia   WORLD JOURNAL OF GASTROENTEROLOGY

Virus interactions with endothelial cell receptors: implications for viral pathogenesis

(2014) Nadine A Dalrymple et al.   Current Opinion in Virology

Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005–2012

(2014) Wen-Yi Zhang et al.   PLoS Neglected Tropical Diseases

Epidemiology of Hantavirus infections in humans: A comprehensive, global overview

(2013) Dionysios Christos Watson et al.   CRITICAL REVIEWS IN MICROBIOLOGY

The Frequency of CD127+ Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

(2013) E.-C. Shin et al.   JOURNAL OF VIROLOGY

Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection

(2013) L. Hua et al.   JOURNAL OF VIROLOGY

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Uncovering the mysteries of hantavirus infections

(2013) Antti Vaheri et al.   NATURE REVIEWS MICROBIOLOGY

Thrombocytopenia as a Predictor of Severe Acute Kidney Injury in Patients with Hantaan Virus Infections

(2013) Meiliang Wang et al.   PLoS One

The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine

(2013) Katarina Radulovic et al.   PLoS One

PD-1 coinhibitory signals: The link between pathogenesis and protection

(2013) Deanna A. Kulpa et al.   SEMINARS IN IMMUNOLOGY

A recombinant pseudotyped lentivirus expressing the envelope glycoprotein of Hantaan virus induced protective immunity in mice

(2013) Lan Yu et al.   Virology Journal

Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome

(2013) Ioannis Kyriakidis et al.   VIRUS RESEARCH

HLA-A2 and B35 Restricted Hantaan Virus Nucleoprotein CD8+ T-Cell Epitope-Specific Immune Response Correlates with Milder Disease in Hemorrhagic Fever with Renal Syndrome

(2013) Ying Ma et al.   PLoS Neglected Tropical Diseases

PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A

(2012) Nikolaos Patsoukis et al.   CELL CYCLE

From crucial to negligible: Functional CD8+T-cell responses and their dependence on CD4+T-cell help

(2012) Melanie Wiesel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Revealing the role of CD4+T cells in viral immunity: Figure 1.

(2012) Andrea J. Sant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of tumoricidal function in CD4+T cells is associated with concomitant memory and terminally differentiated phenotype

(2012) Daniel Hirschhorn-Cymerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a novel B-cell epitope of Hantaan virus glycoprotein recognized by neutralizing 3D8 monoclonal antibody

(2012) G. Yan et al.   JOURNAL OF GENERAL VIROLOGY

Hantaan Virus RNA Load in Patients Having Hemorrhagic Fever With Renal Syndrome: Correlation With Disease Severity

(2012) Jing Yi et al.   JOURNAL OF INFECTIOUS DISEASES

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

Hantavirus infection: an emerging infectious disease causing acute renal failure

(2012) Ellen Krautkrämer et al.   KIDNEY INTERNATIONAL

Hantavirus infections in Europe and their impact on public health

(2012) Antti Vaheri et al.   REVIEWS IN MEDICAL VIROLOGY

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

(2012) N. Patsoukis et al.   Science Signaling

IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques

(2012) Rashmi Jalah et al.   Human Vaccines & Immunotherapeutics

Presence of Activated Airway T Lymphocytes in Human Puumala Hantavirus Disease

(2011) Johan Rasmuson et al.   CHEST

A Fine Romance: T Follicular Helper Cells and B Cells

(2011) Cecile King   IMMUNITY

Cytotoxic CD4 T Cells in Antiviral Immunity

(2011) Nikki B. Marshall et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation

(2011) H. Z. Qui et al.   JOURNAL OF IMMUNOLOGY

HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome

(2011) S. Ranasinghe et al.   JOURNAL OF VIROLOGY

Identification of Three Novel CTL Epitopes within Nucleocapsid Protein of Hantaan Virus

(2011) Meiliang Wang et al.   VIRAL IMMUNOLOGY

Hantavirus pulmonary syndrome

(2011) Adam MacNeil et al.   VIRUS RESEARCH

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7R  in T cells

(2010) C. M. Henriques et al.   BLOOD

Cytolytic CD4+T cells in viral immunity

(2010) Damien Z Soghoian et al.   Expert Review of Vaccines

Emergence of Simian Immunodeficiency Virus-Specific Cytotoxic CD4+ T Cells and Increased Humoral Responses Correlate with Control of Rebounding Viremia in CD8-Depleted Macaques Infected with Rev-Independent Live-Attenuated Simian Immunodeficiency Virus

(2010) A. von Gegerfelt et al.   JOURNAL OF IMMUNOLOGY

Memory CD4+ T cells induce innate responses independently of pathogen

(2010) Tara M Strutt et al.   NATURE MEDICINE

Highly Differentiated, Resting Gn-Specific Memory CD8+ T Cells Persist Years after Infection by Andes Hantavirus

(2010) Tobias Manigold et al.   PLoS Pathogens

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

(2009) Deborah M. Brown et al.   CELLULAR IMMUNOLOGY

CD57+ T lymphocytes and functional immune deficiency

(2009) Daniele Focosi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Analysis of the Immune Response to Hantaan Virus Nucleocapsid Protein C-Terminal-Specific CD8+ T Cells in Patients with Hemorrhagic Fever with Renal Syndrome

(2009) Ping-Zhong Wang et al.   VIRAL IMMUNOLOGY

Polyfunctional T cell responses are a hallmark of HIV-2 infection

(2008) Melody G. Duvall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Cellular Immune Response to Hantaan Virus Nucleocapsid Protein in the Acute Phase of Hemorrhagic Fever with Renal Syndrome: Correlation with Disease Severity

(2008) Meiliang Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Loss of CD127 expression links immune activation and CD4+ T cell loss in HIV infection

(2008) Sandra A. Koesters Kiazyk et al.   TRENDS IN MICROBIOLOGY