A cell atlas of human thymic development defines T cell repertoire formation

Thymic regulatory T cells arise via two distinct developmental programs

(2019) David L. Owen et al.   NATURE IMMUNOLOGY

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens

(2019) Joannah R. Fergusson et al.   Frontiers in Immunology

Rethinking Thymic Tolerance: Lessons from Mice

(2019) Sarah Inglesfield et al.   TRENDS IN IMMUNOLOGY

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

A comprehensive single cell transcriptional landscape of human hematopoietic progenitors

(2019) Danilo Pellin et al.   Nature Communications

BBKNN: fast batch alignment of single cell transcriptomes

(2019) Krzysztof Polański et al.   BIOINFORMATICS

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos

(2019) Yang Zeng et al.   IMMUNITY

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation

(2018) Eric M. Kernfeld et al.   IMMUNITY

Thymic involution and rising disease incidence with age

(2018) Sam Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development

(2018) María J. García-León et al.   DEVELOPMENT

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

(2018) Hui Hu et al.   NUCLEIC ACIDS RESEARCH

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

(2018) Benjamin J. Schmiedel et al.   CELL

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Redefining thymus medulla specialization for central tolerance

(2017) Emilie J. Cosway et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire

(2017) Zachary M. Carico et al.   Cell Reports

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

(2015) Robert J. Mallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells

(2015) Lina Sun et al.   Scientific Reports

Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction

(2015) Noëlla Lopes et al.   Frontiers in Immunology

The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus

(2015) Zicheng Hu et al.   Frontiers in Immunology

The Role of Dendritic Cells in Central Tolerance

(2015) Jaehak Oh et al.   Immune Network

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

(2015) Paul L. Klarenbeek et al.   PLoS One

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

Dynamics of thymus organogenesis and colonization in early human development

(2013) A. M. Farley et al.   DEVELOPMENT

The role of semaphorins and their receptors in vascular development and cancer

(2013) Chenghua Gu et al.   EXPERIMENTAL CELL RESEARCH

Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

(2013) Inge Van de Walle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unifying model for molecular determinants of the preselection Vβ repertoire

(2013) Suhasni Gopalakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Developmentally Regulated Availability of RANKL and CD40 Ligand Reveals Distinct Mechanisms of Fetal and Adult Cross-Talk in the Thymus Medulla

(2012) G. E. Desanti et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Cells Regulate Retinoic Acid Receptor-Dependent Cortical Thymic Epithelial Cell Homeostasis

(2012) K. M. Sitnik et al.   JOURNAL OF IMMUNOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

(2011) I. Van de Walle et al.   BLOOD

Development of PLZF-expressing innate T cells

(2011) Eric S Alonzo et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanisms of thymus organogenesis and morphogenesis

(2011) J. Gordon et al.   DEVELOPMENT

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

(2011) Yu Lei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD161-Expressing Human T Cells

(2011) Joannah R. Fergusson et al.   Frontiers in Immunology

Collectin 11 (CL-11, CL-K1) Is a MASP-1/3-Associated Plasma Collectin with Microbial-Binding Activity

(2010) S. Hansen et al.   JOURNAL OF IMMUNOLOGY

The thymus microenvironment in regulating thymocyte differentiation

(2010) Jacy Gameiro et al.   Cell Adhesion & Migration

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY