Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond

(2016) Praveen Rao et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

The volume-regulated anion channel is formed by LRRC8 heteromers – molecular identification and roles in membrane transport and physiology

(2015) Tobias Stauber   BIOLOGICAL CHEMISTRY

Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer

(2015) J. Bagnall et al.   Integrative Biology

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes

(2015) M G Sanders et al.   Cell Death & Disease

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1β Production

(2014) Kuo-Feng Hua et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

(2014) Elysse M. Knight et al.   NEUROBIOLOGY OF AGING

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flufenamic acid as an ion channel modulator

(2013) Romain Guinamard et al.   PHARMACOLOGY & THERAPEUTICS

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Uncoupling of K+ and Cl− transport across the cell membrane in the process of regulatory volume decrease

(2012) Linjie Yang et al.   BIOCHEMICAL PHARMACOLOGY

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Brain inflammation is induced by co-morbidities and risk factors for stroke

(2011) Caroline Drake et al.   BRAIN BEHAVIOR AND IMMUNITY

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

(2011) Ben G Small et al.   Nature Chemical Biology

Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function

(2011) Danielle K. Lewis et al.   NEUROBIOLOGY OF AGING

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia

(2009) Samantha L. McLean et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis

(2007) Ihsen Youssef et al.   NEUROBIOLOGY OF AGING