Memory CD8 T cell inflation vs tissue-resident memory T cells: Same patrollers, same controllers?

Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells

(2017) Caroline Boudousquie et al.   IMMUNOLOGY

Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent

(2017) Shwetank et al.   IMMUNOLOGY AND CELL BIOLOGY

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Tissue-Resident Memory T Cells Generated by Multiple Immunizations or Localized Deposition Provide Enhanced Immunity

(2017) Brooke Davies et al.   JOURNAL OF IMMUNOLOGY

Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

(2017) Lisa Borkner et al.   JOURNAL OF IMMUNOLOGY

The Chemokine Receptor CXCR3 Promotes CD8+T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection

(2017) Sofia Caldeira-Dantas et al.   JOURNAL OF IMMUNOLOGY

Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung

(2017) A C Zhou et al.   Mucosal Immunology

Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract

(2017) C M Posavad et al.   Mucosal Immunology

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Tissue resident memory T cells and viral immunity

(2017) Pamela C Rosato et al.   Current Opinion in Virology

CD103+ CD8 T Cells in the Toxoplasma-Infected Brain Exhibit a Tissue-Resident Memory Transcriptional Profile

(2017) Tyler A. Landrith et al.   Frontiers in Immunology

Hallmarks of Tissue-Resident Lymphocytes

(2016) Xiying Fan et al.   CELL

α4 β1 integrin promotes accumulation of tissue-resident memory CD8+ T cells in salivary glands

(2016) Sandra Woyciechowski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Local antigen in nonlymphoid tissue promotes resident memory CD8+T cell formation during viral infection

(2016) Tahsin N. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

(2016) Karin Steinbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection

(2016) Jennifer D. Oduro et al.   JOURNAL OF GENERAL VIROLOGY

IL-15–Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells

(2016) Jason M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Viral Persistence Induces Antibody Inflation without Altering Antibody Avidity

(2016) Suzanne P. M. Welten et al.   JOURNAL OF VIROLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

(2016) Rahul Roychoudhuri et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis

(2016) Carolina Perdomo et al.   mBio

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

(2016) Haina Shin et al.   Nature Communications

Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection

(2016) Andrea Marzi et al.   Scientific Reports

A Distinct Lung-Interstitium-Resident Memory CD8 + T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection

(2016) Pavlo Gilchuk et al.   Cell Reports

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

(2016) Iryna Dekhtiarenko et al.   PLoS Pathogens

The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection

(2016) Eleni Panagioti et al.   PLoS Pathogens

CMV-Specific CD8 T Cell Differentiation and Localization: Implications for Adoptive Therapies

(2016) Corinne J. Smith et al.   Frontiers in Immunology

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans

(2015) Felipe A. Vieira Braga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells

(2015) Heather D. Hickman et al.   IMMUNITY

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Skin-resident memory CD4+T cells enhance protection againstLeishmania majorinfection

(2015) Nelson D. Glennie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues

(2015) N. Sharma et al.   JOURNAL OF IMMUNOLOGY

Memory T Cells Specific for Murine Cytomegalovirus Re-Emerge after Multiple Challenges and Recapitulate Immunity in Various Adoptive Transfer Scenarios

(2015) Michael Quinn et al.   JOURNAL OF IMMUNOLOGY

The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+T Cells

(2015) Anke Redeker et al.   JOURNAL OF IMMUNOLOGY

Common clonal origin of central and resident memory T cells following skin immunization

(2015) Olivier Gaide et al.   NATURE MEDICINE

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Asymmetric Cell Division in T Lymphocyte Fate Diversification

(2015) Janilyn Arsenio et al.   TRENDS IN IMMUNOLOGY

A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

(2015) Yoshimi Tsuda et al.   VACCINE

The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8 + T Cells, Facilitating Protection from Local Cytomegalovirus Infection

(2015) Jenny Tosca Thom et al.   Cell Reports

Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells

(2015) Corinne J. Smith et al.   Cell Reports

Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man

(2015) Beatrice Bolinger et al.   Cell Reports

Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8 + T-cell Response and Protects Mice from Melanoma

(2015) Zhijuan Qiu et al.   Cancer Immunology Research

Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells

(2014) Stuart Sims et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The interface between transcriptional and epigenetic control of effector and memory CD8+T-cell differentiation

(2014) Simon M. Gray et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

(2014) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

Clonal Evolution of CD8+T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function

(2014) Ester B. M. Remmerswaal et al.   JOURNAL OF VIROLOGY

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

Persistence of skin-resident memory T cells within an epidermal niche

(2014) A. Zaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Systemic Hematogenous Maintenance of Memory Inflation by MCMV Infection

(2014) Corinne J. Smith et al.   PLoS Pathogens

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

(2014) Marcus Buggert et al.   PLoS Pathogens

Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice

(2013) Guangwu Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thymus-resident memory CD8+T cells mediate local immunity

(2013) Maike Hofmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Viral inoculum dose impacts memory T-cell inflation

(2013) Anke Redeker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

The Context of Gene Expression Defines the Immunodominance Hierarchy of Cytomegalovirus Antigens

(2013) I. Dekhtiarenko et al.   JOURNAL OF IMMUNOLOGY

A New Model for CD8+ T Cell Memory Inflation Based upon a Recombinant Adenoviral Vector

(2013) B. Bolinger et al.   JOURNAL OF IMMUNOLOGY

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus Infection

(2013) S. P. M. Welten et al.   JOURNAL OF VIROLOGY

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

(2013) Jia Zhu et al.   NATURE

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 

(2013) T. Trsan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

A Cytomegalovirus-based Vaccine Expressing a Single Tumor-specific CD8+ T-cell Epitope Delays Tumor Growth in a Murine Model of Prostate Cancer

(2012) Elena N. Klyushnenkova et al.   JOURNAL OF IMMUNOTHERAPY

A Vaccine Based on the Rhesus Cytomegalovirus UL128 Complex Induces Broadly Neutralizing Antibodies in Rhesus Macaques

(2012) Felix Wussow et al.   JOURNAL OF VIROLOGY

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells

(2012) Fumi Miyagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

(2012) S. Ariotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

(2012) L. K. Mackay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory T cell inflation: understanding cause and effect

(2012) Geraldine A. O’Hara et al.   TRENDS IN IMMUNOLOGY

A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice

(2012) Rob Tierney et al.   VACCINE

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

(2011) Atanas Kamburov et al.   BIOINFORMATICS

Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes

(2011) E. B. M. Remmerswaal et al.   BLOOD

Memory T cells as an occupying force

(2011) Michael J. Bevan   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell help permits memory CD8+ T-cell inflation during cytomegalovirus latency

(2011) Senta M. Walton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory

(2011) Andrea M. Siegel et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency

(2011) C. K. Seckert et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

KLRG1 + NKG2A + CD8 T Cells Mediate Protection and Participate in Memory Responses during γ-Herpesvirus Infection

(2011) Stephanie S. Cush et al.   JOURNAL OF IMMUNOLOGY

Increased Numbers of Preexisting Memory CD8 T Cells and Decreased T-bet Expression Can Restrain Terminal Differentiation of Secondary Effector and Memory CD8 T Cells

(2011) Nikhil S. Joshi et al.   JOURNAL OF IMMUNOLOGY

Environmental and Antigen Receptor-Derived Signals Support Sustained Surveillance of the Lungs by Pathogen-Specific Cytotoxic T Lymphocytes

(2011) Y.-T. Lee et al.   JOURNAL OF VIROLOGY

Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

(2011) Thomas Gebhardt et al.   NATURE

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

(2011) Sonia Feau et al.   NATURE IMMUNOLOGY

Regional and mucosal memory T cells

(2011) Brian S Sheridan et al.   NATURE IMMUNOLOGY

A Dominant Role for the Immunoproteasome in CD8+ T Cell Responses to Murine Cytomegalovirus

(2011) Sarah Hutchinson et al.   PLoS One

E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands

(2011) M. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the Requirements for Maintenance of the CMV-Specific Memory T-Cell Pool

(2011) Andrea I. Loewendorf et al.   VIRAL IMMUNOLOGY

A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus

(2011) Yoshimi Tsuda et al.   PLoS Neglected Tropical Diseases

Sustained CD8+ T Cell Memory Inflation after Infection with a Single-Cycle Cytomegalovirus

(2011) Christopher M. Snyder et al.   PLoS Pathogens

Non-Hematopoietic Cells in Lymph Nodes Drive Memory CD8 T Cell Inflation during Murine Cytomegalovirus Infection

(2011) Nicole Torti et al.   PLoS Pathogens

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells

(2010) Ian R. Humphreys et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Generation of effector CD8+ T cells and their conversion to memory T cells

(2010) Weiguo Cui et al.   IMMUNOLOGICAL REVIEWS

Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

(2010) Kirsten M.L. Hertoghs et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

(2009) Rachel L. Rutishauser et al.   IMMUNITY

Diversity in T Cell Memory: An Embarrassment of Riches

(2009) Stephen C. Jameson et al.   IMMUNITY

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

(2009) Axel Kallies et al.   IMMUNITY

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflation and Long-Term Maintenance of CD8 T Cells Responding to a Latent Herpesvirus Depend upon Establishment of Latency and Presence of Viral Antigens

(2009) A. Lang et al.   JOURNAL OF IMMUNOLOGY

CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection

(2009) C. M. Snyder et al.   JOURNAL OF IMMUNOLOGY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

(2008) Christopher M. Snyder et al.   IMMUNITY

Blimp-1 directly repressesIl2and theIl2activatorFos, attenuating T cell proliferation and survival

(2008) Gislâine A. Martins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innocents abroad: regulating where naive T cells go

(2008) Barrett J Rollins   NATURE IMMUNOLOGY

CXCR4-CCR5: A couple modulating T cell functions

(2008) R. L. Contento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin

(2008) A. M. Intlekofer et al.   SCIENCE