Wound repair and regeneration: Mechanisms, signaling, and translation

A randomized trial of prophylactic palifermin on gastrointestinal toxicity after intensive induction therapy for acute myeloid leukaemia

(2014) Kenneth F. Bradstock et al.   BRITISH JOURNAL OF HAEMATOLOGY

Macrophages modulate adult zebrafish tail fin regeneration

(2014) T. A. Petrie et al.   DEVELOPMENT

Recapitulation of morphogenetic cell shape changes enables wound re-epithelialisation

(2014) William Razzell et al.   DEVELOPMENT

Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity

(2014) Robert Nunan et al.   Disease Models & Mechanisms

Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type

(2014) M. Sasaki et al.   JOURNAL OF IMMUNOLOGY

Genetic Ablation of Mast Cells Redefines the Role of Mast Cells in Skin Wound Healing and Bleomycin-Induced Fibrosis

(2014) Sebastian Willenborg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The effects of social isolation on wound healing mechanisms in female mice

(2014) Leah M. Pyter et al.   PHYSIOLOGY & BEHAVIOR

Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa

(2014) V. Sebastiano et al.   Science Translational Medicine

Clinical application of growth factors and cytokines in wound healing

(2014) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Deregulation of epidermal stem cell niche contributes to pathogenesis of nonhealing venous ulcers

(2014) Olivera Stojadinovic et al.   WOUND REPAIR AND REGENERATION

Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers

(2014) J.R. Hanft et al.   Journal of Wound Care

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165

(2013) Stephanie Traub et al.   BIOMATERIALS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

(2013) B. A. Schmidt et al.   DEVELOPMENT

Biological therapies for the treatment of cutaneous wounds: Phase III and launched therapies

(2013) Robert C Rennert et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Proteolytic Processing Regulates Placental Growth Factor Activities

(2013) Daniel C. Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrosing connective tissue disorders of the skin: Molecular similarities and distinctions

(2013) Johanna Canady et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Mast Cells Are Dispensable for Normal and Activin-Promoted Wound Healing and Skin Carcinogenesis

(2013) M. Antsiferova et al.   JOURNAL OF IMMUNOLOGY

Adult Zebrafish as a Model System for Cutaneous Wound-Healing Research

(2013) Rebecca Richardson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Zebrafish as a model for the study of neutrophil biology

(2013) Katherine M. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling

(2013) Wei Chin Chou et al.   NATURE MEDICINE

Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection

(2013) Irena Pastar et al.   PLoS One

Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load

(2013) Olivera Stojadinovic et al.   PLoS One

Generation of 3D Skin Equivalents Fully Reconstituted from Human Induced Pluripotent Stem Cells (iPSCs)

(2013) Munenari Itoh et al.   PLoS One

Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo

(2013) Yulia Shamis et al.   PLoS One

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients

(2013) Christoph Krisp et al.   PROTEOMICS

A Stem Cell Perspective on Cellular Engineering

(2013) S. Doulatov et al.   SCIENCE

US-National Institutes of Health-funded research for cutaneous wounds in 2012

(2013) Nicholas A. Richmond et al.   WOUND REPAIR AND REGENERATION

The Wound Microbiome: Modern Approaches to Examining the Role of Microorganisms in Impaired Chronic Wound Healing

(2013) Ana M. Misic et al.   Advances in Wound Care

Clinical identification of bacteria in human chronic wound infections: culturing vs. 16S ribosomal DNA sequencing

(2012) Daniel D Rhoads et al.   BMC INFECTIOUS DISEASES

Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish

(2012) Luke Pase et al.   CURRENT BIOLOGY

Update on cardiac stem cell therapy in heart failure

(2012) Peter Donndorf et al.   CURRENT OPINION IN CARDIOLOGY

The Neuropathic Diabetic Foot Ulcer Microbiome Is Associated With Clinical Factors

(2012) S. E. Gardner et al.   DIABETES

Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing

(2012) Irena Pastar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin

(2012) M. Meyer et al.   JOURNAL OF CELL SCIENCE

Geographic variation in Medicare spending and mortality for diabetic patients with foot ulcers and amputations

(2012) Michael R. Sargen et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness

(2012) Helen A Thomason et al.   JOURNAL OF PATHOLOGY

Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial

(2012) Robert S Kirsner et al.   LANCET

RETRACTED: Engineered whole organs and complex tissues

(2012) Stephen F Badylak et al.   LANCET

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

U.S. Regulation of Stem Cells as Medical Products

(2012) D. Sipp et al.   SCIENCE

Regeneration: The ultimate example of wound healing

(2012) Prayag Murawala et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The FDA and designing clinical trials for chronic cutaneous ulcers

(2012) Andrea D. Maderal et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nerve dependence in tissue, organ, and appendage regeneration

(2012) Anoop Kumar et al.   TRENDS IN NEUROSCIENCES

Analysis of the proteomic profile of chronic pressure ulcers

(2012) Laura E. Edsberg et al.   WOUND REPAIR AND REGENERATION

Microbiome dynamics of human epidermis following skin barrier disruption

(2012) Patrick LJM Zeeuwen et al.   GENOME BIOLOGY

The role of estrogen deficiency in skin ageing and wound healing

(2011) Elaine Emmerson et al.   BIOGERONTOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Swatting flies: modelling wound healing and inflammation in Drosophila

(2011) W. Razzell et al.   Disease Models & Mechanisms

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Fluorescent fibre-optic confocal imaging of lesional and non-lesional psoriatic skin compared with normal skinin vivo

(2011) Christian Suihko et al.   SKIN RESEARCH AND TECHNOLOGY

Multiplexed molecular descriptors of pressure ulcers defined by imaging mass spectrometry

(2011) Domenico Taverna et al.   WOUND REPAIR AND REGENERATION

Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges

(2011) François Berthiaume et al.   Annual Review of Chemical and Biomolecular Engineering

Genetics of keloid scarring

(2010) Barbara Shih et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

FGF-2 and VEGF functionalization of starPEG–heparin hydrogels to modulate biomolecular and physical cues of angiogenesis

(2010) Andrea Zieris et al.   BIOMATERIALS

The role of keratinocytes in defense against infection

(2010) Jens-Michael Schröder   CURRENT OPINION IN INFECTIOUS DISEASES

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

(2010) Jacinta Caddy et al.   DEVELOPMENTAL CELL

A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes

(2010) C. Lesch et al.   GENETICS

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Exploring the “Hair Growth–Wound Healing Connection”: Anagen Phase Promotes Wound Re-Epithelialization

(2010) David M. Ansell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Differential Proteomic Analysis Distinguishes Tissue Repair Biomarker Signatures in Wound Exudates Obtained from Normal Healing and Chronic Wounds

(2010) Sabine A. Eming et al.   JOURNAL OF PROTEOME RESEARCH

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(2010) Irena Pastar et al.   MOLECULAR MEDICINE

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa

(2010) John E. Wagner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response

(2010) E. A. Grice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

A Matched Cohort Study of the Risk of Cancer in Users of Becaplermin

(2010) Najat Ziyadeh et al.   Advances in Skin & Wound Care

Alternative Proteolytic Processing of Hepatocyte Growth Factor during Wound Repair

(2009) Nils Buchstein et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of the immune response potentiates tadpole tail regeneration during the refractory period

(2009) T. Fukazawa et al.   DEVELOPMENT

Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes

(2009) Tanya Shaw et al.   EMBO REPORTS

Genetic Screen in Drosophila melanogaster Uncovers a Novel Set of Genes Required for Embryonic Epithelial Repair

(2009) I. Campos et al.   GENETICS

Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy

(2009) Stephanie K. Beidler et al.   JOURNAL OF VASCULAR SURGERY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations

(2009) John F. Bateman et al.   NATURE REVIEWS GENETICS

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Community Analysis of Chronic Wound Bacteria Using 16S rRNA Gene-Based Pyrosequencing: Impact of Diabetes and Antibiotics on Chronic Wound Microbiota

(2009) Lance B. Price et al.   PLoS One

Targeting Nonhealing Ulcers of Lower Extremity in Human Through Autologous Bone Marrow-Derived Mesenchymal Stem Cells

(2009) Nihar Ranjan Dash et al.   REJUVENATION RESEARCH

IMMUNOLOGY: Dangers In and Out

(2009) M. E. Bianchi et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Topographical and Temporal Diversity of the Human Skin Microbiome

(2009) E. A. Grice et al.   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Interrelation of immunity and tissue repair or regeneration

(2009) Sabine A. Eming et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microbial diversity in chronic open wounds

(2009) Daniel N. Frank et al.   WOUND REPAIR AND REGENERATION

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers

(2008) Olivera Stojadinovic et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring

(2008) Ryoichi Mori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fibroblast Dysfunction Is a Key Factor in the Non-Healing of Chronic Venous Leg Ulcers

(2008) Ivan B. Wall et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A gene signature of nonhealing venous ulcers: Potential diagnostic markers

(2008) Carlos A. Charles et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF

(2008) Harold Brem et al.   Journal of Translational Medicine

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Biofilms in chronic wounds

(2008) Garth A. James et al.   WOUND REPAIR AND REGENERATION

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly

(2008) Matthew J Hardman et al.   GENOME BIOLOGY

Metalloproteinases and their inhibitors: Regulators of wound healing

(2007) S GILL et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY